Edinburgh Research Explorer

Prof Seth Grant

Personal Chair of Molecular Neuroscience

  1. PSD-95 Is Essential for Hallucinogen and Atypical Antipsychotic Drug Actions at Serotonin Receptors

    Abbas, A. I., Yadav, P. N., Yao, W-D., Arbuckle, M. I., Grant, S. G. N., Caron, M. G. & Roth, B. L., 3 Jun 2009, In : Journal of Neuroscience. 29, 22, p. 7124-7136 13 p.

    Research output: Contribution to journalArticle

  2. The SH3 domain of postsynaptic density 95 mediates inflammatory pain through phosphatidylinositol-3-kinase recruitment

    Arbuckle, M. I., Komiyama, N. H., Delaney, A., Coba, M., Garry, E. M., Rosie, R., Allchorne, A. J., Forsyth, L. H., Bence, M., Carlisle, H. J., O'Dell, T. J., Mitchell, R., Fleetwood-Walker, S. M. & Grant, S., Jun 2010, In : EMBO Reports. 11, 6, p. 473-478 6 p.

    Research output: Contribution to journalArticle

  3. Reconstructing protein complexes: From proteomics to systems biology

    Armstrong, J. D., Pocklington, A. J., Cumiskey, M. A. & Grant, S. G. N., 2006, In : Proteomics. 6, 17, p. 4724-4731 8 p.

    Research output: Contribution to journalArticle

  4. Evolution of the synapse proteome

    Armstrong, J. D., Malik, B., Pocklington, A., Emes, R. & Grant, S., 2009, In : Journal of neurogenetics. 23, p. S34-S35 2 p.

    Research output: Contribution to journalMeeting abstract

  5. Selectivity, efficacy and toxicity studies of UCCB01-144, a dimeric neuroprotective PSD-95 inhibitor

    Bach, A., Clausen, B. H., Kristensen, L. K., Andersen, M. G., Ellman, D. G., Hansen, P. B. L., Hasseldam, H., Heitz, M., Özcelik, D., Tuck, E. J., Kopanitsa, M. V., Grant, S. G. N., Lykke-hartmann, K., Johansen, F. F., Lambertsen, K. L. & Strømgaard, K., 15 May 2019, In : Neuropharmacology. 150

    Research output: Contribution to journalArticle

  6. Convergence of hippocampal pathophysiology in Syngap+/- and Fmr1-/y mice

    Barnes, S., Wijetunge, L., Jackson, A. D., Katsanevaki, D., Osterweil, E., Komiyama, N., Grant, S., Bear, M. F., Nägerl, U. V., Kind, P. & Wyllie, D., 11 Nov 2015, In : Journal of Neuroscience. 35, 45, p. 15073-15081

    Research output: Contribution to journalArticle

  7. Synaptic Ras GTPase activating protein regulates pattern formation in the trigeminal system of mice

    Barnett, M. W., Watson, R. F., Vitalis, T., Porter, K., Komiyama, N. H., Stoney, P. N., Gillingwater, T. H., Grant, S. G. N. & Kind, P. C., 2006, In : Journal of Neuroscience. 26, 5, p. 1355-65 11 p.

    Research output: Contribution to journalArticle

  8. Characterization of the proteome, diseases and evolution of the human postsynaptic density

    Bayes, A., Van De Lagemaat, L., Collins, M. O., Croning, M. D. R., Whittle, I. R., Choudhary, J. S. & Grant, S. G. N., Jan 2011, In : Nature Neuroscience. 14, 1, p. 19-21 3 p.

    Research output: Contribution to journalArticle

  9. Comparative Study of Human and Mouse Postsynaptic Proteomes Finds High Compositional Conservation and Abundance Differences for Key Synaptic Proteins

    Bayes, A., Collins, M. O., Croning, M. D. R., Van De Lagemaat, L., Choudhary, J. S. & Grant, S. G. N., 5 Oct 2012, In : PLoS ONE. 7, 10, p. - 13 p., e46683.

    Research output: Contribution to journalArticle

  10. Human post-mortem synapse proteome integrity screening for proteomic studies of postsynaptic complexes

    Bayés, A., Collins, M. O., Galtrey, C. M., Simonnet, C., Roy, M., Croning, M., Gou, G., van de Lagemaat, L. N., Milward, D., Whittle, I. R., Smith, C., Choudhary, J. S. & Grant, S., 28 Nov 2014, In : Molecular brain research. 7, 1, p. 88

    Research output: Contribution to journalArticle

  11. Evolution of complexity in the zebrafish synapse proteome

    Bayés, À., Collins, M. O., Reig-viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J. S., Emes, R. D. & Grant, S. G. N., 2 Mar 2017, In : Nature Communications. 8, 14613.

    Research output: Contribution to journalArticle

  12. Haploinsufficiency of EHMT1 improves pattern separation and increases hippocampal cell proliferation

    Benevento, M., Oomen, C. A., Horner, A. E., Amiri, H., Jacobs, T., Pauwels, C., Frega, M., Kleefstra, T., Kopanitsa, M. V., Grant, S., Bussey, T. J., Saksida, L. M., Van der Zee, C. E. E. M., van Bokhoven, H., Glennon, J. C. & Kasri, N. N., 10 Jan 2017, In : Scientific Reports.

    Research output: Contribution to journalArticle

  13. PSD95 nanoclusters are postsynaptic building blocks in hippocampus circuits

    Broadhead, M. J., Horrocks, M. H., Zhu, F., Muresan, L., Benavides-Piccione, R., DeFelipe, J., Fricker, D., Kopanitsa, M. V., Duncan, R. R., Klenerman, D., Komiyama, N. H., Lee, S. F. & Grant, S. G. N., 25 Apr 2016, In : Scientific Reports. 6, p. 24626

    Research output: Contribution to journalArticle

  14. Regional localization of the murine Duchenne muscular dystrophy gene on the mouse X chromosome

    Chamberlain, J. S., Grant, S. G., Reeves, A. A., Mullins, L. J., Stephenson, D. A., Hoffman, E. P., Monaco, A. P., Kunkel, L. M., Caskey, C. T. & Chapman, V. M., Nov 1987, In : Somatic Cell and Molecular Genetics. 13, 6, p. 671-8 8 p.

    Research output: Contribution to journalArticle

  15. Quantitative differences in developmental profiles of spontaneous activity in cortical and hippocampal cultures

    Charlesworth, P., Cotterill, E., Morton, A., Grant, S. G. N. & Eglen, S. J., 28 Jan 2015, In : Neural Development. 10, p. 1

    Research output: Contribution to journalArticle

  16. Canalization of genetic and pharmacological perturbations in developing primary neuronal activity patterns

    Charlesworth, P., Morton, A., Eglen, S. J., Komiyama, N. H. & Grant, S. G. N., 26 Jul 2015, In : Neuropharmacology.

    Research output: Contribution to journalArticle

  17. Neurotransmitters Drive Combinatorial Multistate Postsynaptic Density Networks

    Coba, M. P., Pocklington, A. J., Collins, M. O., Kopanitsa, M. V., Uren, R. T., Swamy, S., Croning, M. D. R., Choudhary, J. S. & Grant, S. G. N., Apr 2009, In : Science Signaling. 2, 68, ra19.

    Research output: Contribution to journalArticle

  18. Dlgap1 knockout mice exhibit alterations of the postsynaptic density and selective reductions in sociability

    Coba, M. P., Ramaker, M. J., Ho, E. V., Thompson, S. L., Komiyama, N. H., Grant, S. G. N., Knowles, J. A. & Dulawa, S. C., 2 Feb 2018, In : Scientific Reports. 8, 1

    Research output: Contribution to journalArticle

  19. TNiK Is Required for Postsynaptic and Nuclear Signaling Pathways and Cognitive Function

    Coba, M. P., Komiyama, N. H., Nithianantharajah, J., Kopanitsa, M. V., Indersmitten, T., Skene, N. G., Tuck, E. J., Fricker, D. G., Elsegood, K. A., Stanford, L. E., Afinowi, N. O., Saksida, L. M., Bussey, T. J., O'Dell, T. J. & Grant, S. G. N., 3 Oct 2012, In : Journal of Neuroscience. 32, 40, p. 13987-13999 13 p.

    Research output: Contribution to journalArticle

  20. Altered Thalamocortical Development in the SAP102 Knockout Model of Intellectual Disability

    Crocker-Buque, A., Currie, S. P., Luz, L. L., Grant, S. G., Duffy, K. R., Kind, P. C. & Daw, M. I., 27 Jul 2016, In : Human Molecular Genetics.

    Research output: Contribution to journalArticle

  21. G2Cdb: the Genes to Cognition database

    Croning, M. D. R., Marshall, M. C., McLaren, P., Armstrong, J. D. & Grant, S. G. N., Jan 2009, In : Nucleic Acids Research. 37, p. D846-D851 6 p.

    Research output: Contribution to journalArticle

  22. Automated design of genomic Southern blot probes

    Croning, M. D. R., Fricker, D. G., Komiyama, N. H. & Grant, S. G. N., 2010, In : BMC Genomics. 11, p. 74

    Research output: Contribution to journalArticle

  23. Synapse-associated protein 102/dlgh3 couples the NMDA receptor to specific plasticity pathways and learning strategies

    Cuthbert, P. C., Stanford, L. E., Coba, M. P., Ainge, J. A., Fink, A. E., Opazo, P., Delgado, J. Y., Komiyama, N. H., O'Dell, T. J. & Grant, S. G. N., 7 Mar 2007, In : Journal of Neuroscience. 27, 10, p. 2673-82 10 p.

    Research output: Contribution to journalArticle

  24. Integrin-mediated axoglial interactions initiate myelination in the central nervous system

    Câmara, J., Wang, Z., Nunes-Fonseca, C., Friedman, H. C., Grove, M., Sherman, D. L., Komiyama, N. H., Grant, S. G., Brophy, P. J., Peterson, A. & ffrench-Constant, C., May 2009, In : The Journal of Cell Biology. 185, 4, p. 699-712 14 p.

    Research output: Contribution to journalArticle

  25. Tolerance to ethanol intoxication after chronic ethanol: role of GluN2A and PSD-95

    Daut, R. A., Busch, E. F., Ihne, J., Fisher, D., Mishina, M., Grant, S. G. N., Camp, M. & Holmes, A., Mar 2015, In : Addiction Biology. 20, 2, p. 259-262 4 p.

    Research output: Contribution to journalArticle

  26. CYFIP1 Coordinates mRNA Translation and Cytoskeleton Remodeling to Ensure Proper Dendritic Spine Formation

    De Rubeis, S., Pasciuto, E., Li, K. W., Fernández, E., Di Marino, D., Buzzi, A., Ostroff, L. E., Klann, E., Zwartkruis, F. J. T., Komiyama, N. H., Grant, S. G. N., Poujol, C., Choquet, D., Achsel, T., Posthuma, D., Smit, A. B. & Bagni, C., 18 Sep 2013, In : Neuron. 79, 6, p. 1169-82 14 p.

    Research output: Contribution to journalArticle

  27. Probing the Modulation of Acute Ethanol Intoxication by Pharmacological Manipulation of the NMDAR Glycine Co-Agonist Site

    DeBrouse, L., Hurd, B., Kiselycznyk, C., Plitt, A., Todaro, A., Mishina, M., Grant, S. G. N., Camp, M., Gunduz-Cinar, O. & Holmes, A., Feb 2013, In : Alcoholism-Clinical and experimental research. 37, 2, p. 223-233 11 p.

    Research output: Contribution to journalArticle

  28. NMDA receptor modulation of glutamate release in activated neutrophils

    Del Arroyo, A. G., Hadjihambi, A., Sanchez, J., Turovsky, E., Kasymov, V., Cain, D., Nightingale, T. D., Lambden, S., Grant, S. G. N., Gourine, A. V. & Ackland, G. L., 8 Aug 2019, In : EBioMedicine.

    Research output: Contribution to journalArticle

  29. Rapid homeostatic downregulation of LTP by extrasynaptic GluN2B receptors

    Delgado, J. Y., Fink, A. E., Grant, S. G. N., O'Dell, T. J. & Opazo, P., Nov 2018, In : Journal of Neurophysiology.

    Research output: Contribution to journalArticle

  30. In Vivo Composition of NMDA Receptor Signaling Complexes Differs between Membrane Subdomains and Is Modulated by PSD-95 And PSD-93

    Delint-Ramirez, I., Fernandez, E., Bayes, A., Kicsi, E., Komiyama, N. & Grant, S. G. N., 16 Jun 2010, In : The Journal of Neuroscience. 30, 24, p. 8162-8170 9 p.

    Research output: Contribution to journalArticle

  31. Thigh-Length Versus Below-Knee Stockings for Deep Venous Thrombosis Prophylaxis After Stroke: A Randomized Trial

    Dennis, M., Cranswick, G., Deary, A., Fraser, A., Graham, C., Grant, S., Gunkel, A., Hunter, J., MacRae, A., Perry, D., Soosay, V., Williams, C., Williamson, A., Young, A., Sandercock, P., Reid, J., Murray, G., Venables, G., Rudd, A., Bowler, G. & 10 others, Celani, M. G., Ricci, S., Lindley, R., Hautvast, M., Paterson, M., Ting, T., Baigent, C., Bamford, J., Slattery, J. & CLOTS Trial Collaborat, 2 Nov 2010, In : Annals of Internal Medicine. 153, 9, p. 553-562 10 p.

    Research output: Contribution to journalArticle

  32. Evolutionary expansion and anatomical specialization of synapse proteome complexity

    Emes, R. D., Pocklington, A. J., Anderson, C. N. G., Bayes, A., Collins, M. O., Vickers, C. A., Croning, M. D. R., Malik, B. R., Choudhary, J. S., Armstrong, D. & Grant, S., Jul 2008, In : Nature Neuroscience. 11, 7, p. 799-806 8 p.

    Research output: Contribution to journalArticle

  33. Evolution of Synapse Complexity and Diversity

    Emes, R. D. & Grant, S. G. N., 2012, ANNUAL REVIEW OF NEUROSCIENCE, VOL 35. Hyman, SE. (ed.). PALO ALTO: ANNUAL REVIEWS, p. 111-131 21 p. (Annual Review of Neuroscience; vol. 35).

    Research output: Chapter in Book/Report/Conference proceedingChapter

  34. Separable features of visual cortical plasticity revealed by N-methyl-D-aspartate receptor 2A signaling

    Fagiolini, M., Katagiri, H., Miyamoto, H., Mori, H., Grant, S. G. N., Mishina, M. & Hensch, T. K., 4 Mar 2003, In : Proceedings of the National Academy of Sciences. 100, 5, p. 2854-9 6 p.

    Research output: Contribution to journalArticle

  35. Neurobeachin Regulates Glutamate- and GABA-Receptor Targeting to Synapses via Distinct Pathways

    Farzana, F., Zalm, R., Chen, N., Li, K. W., Grant, S. G. N., Smit, A. B., Toonen, R. F. & Verhage, M., 2 May 2016, In : Molecular Neurobiology. 53, 4, p. 2112-2123 12 p.

    Research output: Contribution to journalArticle

  36. Arc requires PSD95 for assembly into postsynaptic complexes involved with brain disease and intelligence

    Fernandez, E., Collins, M. O., Frank, R. A. W., Zhu, F., Kopanitsa, M. V., Nithianantharajah, J., Lempriere, S., Fricker, D. G., Elsegood, K. A., McLaughlin, C., Croning, M. D. R., McLean, C., Armstrong, J. D., Hill, W. D., Deary, I., Cencelli, G., Bagni, C., Fromer, M., Purcell, S. M., Pocklington, A. J. & 3 others, Choudhary, J. S., Komiyama, N. & Grant, S., 17 Oct 2017, In : Cell Reports. 21, 3, p. 679-691

    Research output: Contribution to journalArticle

  37. Targeted tandem affinity purification of PSD-95 recovers core postsynaptic complexes and schizophrenia susceptibility proteins

    Fernandez, E., Collins, M. O., Uren, R. T., Kopanitsa, M. V., Komiyama, N. H., Croning, M. D. R., Zografos, L., Armstrong, J. D., Choudhary, J. S. & Grant, S. G. N., May 2009, In : Molecular Systems Biology. 5, p. - 17 p., 269.

    Research output: Contribution to journalArticle

  38. Association of Mouse Dlg4 (PSD-95) Gene Deletion and Human DLG4 Gene Variation With Phenotypes Relevant to Autism Spectrum Disorders and Williams' Syndrome

    Feyder, M., Karlsson, R-M., Mathur, P., Lyman, M., Bock, R., Momenan, R., Munasinghe, J., Scattoni, M. L., Ihne, J., Camp, M., Graybeal, C., Strathdee, D., Begg, A., Alvarez, V. A., Kirsch, P., Rietschel, M., Cichon, S., Walter, H., Meyer-Lindenberg, A., Grant, S. G. N. & 1 others, Holmes, A., Dec 2010, In : American Journal of Psychiatry. 167, 12, p. 1508-1517 10 p.

    Research output: Contribution to journalArticle

  39. Durable fear memories require PSD-95

    Fitzgerald, P. J., Pinard, C. R., Camp, M. C., Feyder, M., Sah, A., Bergstrom, H. C., Graybeal, C., Liu, Y., Schlüter, O. M., Grant, S. G., Singewald, N., Xu, W. & Holmes, A., Jul 2015, In : Molecular Psychiatry. 20, 7, p. 901-12 12 p.

    Research output: Contribution to journalArticle

  40. NMDA receptors are selectively partitioned into complexes and supercomplexes during synapse maturation

    Frank, R. A. W., Komiyama, N. H., Ryan, T. J., Zhu, F., O'Dell, T. J. & Grant, S. G. N., 27 Apr 2016, In : Nature Communications. 7, p. 11264

    Research output: Contribution to journalArticle

  41. Hierarchical organisation and genetically separable subfamilies of PSD95 postsynaptic supercomplexes

    Frank, R. A. W., Zhu, F., Komiyama, N. H. & Grant, S. G. N., 28 Apr 2017, In : Journal of Neurochemistry.

    Research output: Contribution to journalArticle

  42. Supramolecular organization of NMDA receptors and the postsynaptic density

    Frank, R. A. & Grant, S. G., Aug 2017, In : Current Opinion in Neurobiology. 45, p. 139-147 9 p.

    Research output: Contribution to journalArticle

  43. De novo mutations in schizophrenia implicate synaptic networks

    Fromer, M., Pocklington, A. J., Kavanagh, D. H., Williams, H. J., Dwyer, S., Gormley, P., Georgieva, L., Rees, E., Palta, P., Ruderfer, D. M., Carrera, N., Humphreys, I., Johnson, J. S., Roussos, P., Barker, D. D., Banks, E., Milanova, V., Grant, S. G., Hannon, E., Rose, S. A. & 12 others, Chambert, K., Mahajan, M., Scolnick, E. M., Moran, J. L., Kirov, G., Palotie, A., McCarroll, S. A., Holmans, P., Sklar, P., Owen, M. J., Purcell, S. M. & O'Donovan, M. C., 13 Feb 2014, In : Nature. 506, 7487, p. 179-+ 16 p.

    Research output: Contribution to journalArticle

  44. Synapse proteomics of multiprotein complexes: en route from genes to nervous system diseases

    Grant, S. G. N., Marshall, M. C., Page, K-L., Cumiskey, M. A. & Armstrong, J. D., 2005, In : Human Molecular Genetics. 14, suppl 2, p. R225-R234 10 p.

    Research output: Contribution to journalArticle

  45. The molecular evolution of the vertebrate behavioural repertoire

    Grant, S. G. N., 5 Jan 2016, In : Philosophical Transactions of the Royal Society B: Biological Sciences. 371, 1685, 20150051.

    Research output: Contribution to journalArticle

  46. The Organization and integrative function of the post-synaptic proteome

    Grant, S., Husi, H., Choudhary, J., Cumiskey, M., Blackstock, W. & Armstrong, D., 2004, Excitatory-Inhibitory Balance: Synapses, Circuits, Systems. KLUWER ACADEMIC/PLENUM PUBL, p. 13-44 32 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

  47. Synaptopathies: diseases of the synaptome

    Grant, S. G., 2012, In : Current Opinion in Neurobiology.

    Research output: Contribution to journalArticle

  48. Synapse molecular complexity and the plasticity-behaviour problem

    Grant, S., 15 Nov 2018, In : Brain and Neuroscience Advances.

    Research output: Contribution to journalArticle

  49. SnapShot: Organizational principles of the postsynaptic proteome

    Grant, S. G. N., 16 Oct 2013, In : Neuron. 80, 2, p. 534.e1

    Research output: Contribution to journalArticle

  50. The Synaptomic Theory of Behavior and Brain Disease

    Grant, S. G. N., 18 Mar 2019, In : Cold Spring Harbor Symposia on Quantitative Biology. p. 037887

    Research output: Contribution to journalArticle

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