Edinburgh Research Explorer

Prof Seth Grant

Personal Chair of Molecular Neuroscience

  1. In Vivo Composition of NMDA Receptor Signaling Complexes Differs between Membrane Subdomains and Is Modulated by PSD-95 And PSD-93

    Delint-Ramirez, I., Fernandez, E., Bayes, A., Kicsi, E., Komiyama, N. & Grant, S. G. N., 16 Jun 2010, In : The Journal of Neuroscience. 30, 24, p. 8162-8170 9 p.

    Research output: Contribution to journalArticle

  2. A genomic lifespan program that reorganises the young adult brain is targeted in schizophrenia

    Skene, N. G., Roy, M. & Grant, S. G., 12 Sep 2017, In : eLIFE. 6

    Research output: Contribution to journalArticle

  3. A polygenic burden of rare disruptive mutations in schizophrenia

    Purcell, S. M., Moran, J. L., Fromer, M., Ruderfer, D., Solovieff, N., Roussos, P., O'Dushlaine, C., Chambert, K., Bergen, S. E., Kahler, A., Duncan, L., Stahl, E., Genovese, G., Fernandez, E., Collins, M. O., Komiyama, N. H., Choudhary, J. S., Magnusson, P. K. E., Banks, E., Shakir, K. & 12 others, Garimella, K., Fennell, T., DePristo, M., Grant, S. G. N., Haggarty, S. J., Gabriel, S., Scolnick, E. M., Lander, E. S., Hultman, C. M., Sullivan, P. F., McCarroll, S. A. & Sklar, P., 13 Feb 2014, In : Nature. 506, 7487, p. 185-+ 17 p.

    Research output: Contribution to journalArticle

  4. ATP from synaptic terminals and astrocytes regulates NMDA receptors and synaptic plasticity through PSD-95 multi-protein complex

    Lalo, U., Palygin, O., Verkhratsky, A., Grant, S. & Pankratov, Y., 19 Sep 2016, In : Scientific Reports. 6, 20 p., 33609.

    Research output: Contribution to journalArticle

  5. Altered Thalamocortical Development in the SAP102 Knockout Model of Intellectual Disability

    Crocker-Buque, A., Currie, S. P., Luz, L. L., Grant, S. G., Duffy, K. R., Kind, P. C. & Daw, M. I., 27 Jul 2016, In : Human Molecular Genetics.

    Research output: Contribution to journalArticle

  6. An anatomically comprehensive atlas of the adult human brain transcriptome

    Hawrylycz, M. J., Lein, E. S., Guillozet-Bongaarts, A. L., Shen, E. H., Ng, L., Miller, J. A., Van De Lagemaat, L., Smith, K. A., Ebbert, A., Riley, Z. L., Abajian, C., Beckmann, C. F., Bernard, A., Bertagnolli, D., Boe, A. F., Cartagena, P. M., Chakravarty, M. M., Chapin, M., Chong, J., Dalley, R. A. & 47 others, Daly, B. D., Dang, C., Datta, S., Dee, N., Dolbeare, T. A., Faber, V., Feng, D., Fowler, D. R., Goldy, J., Gregor, B. W., Haradon, Z., Haynor, D. R., Hohmann, J. G., Horvath, S., Howard, R. E., Jeromin, A., Jochim, J. M., Kinnunen, M., Lau, C., Lazarz, E. T., Lee, C., Lemon, T. A., Li, L., Li, Y., Morris, J. A., Overly, C. C., Parker, P. D., Parry, S. E., Reding, M., Royall, J. J., Schulkin, J., Sequeira, P. A., Slaughterbeck, C. R., Smith, S. C., Sodt, A. J., Sunkin, S. M., Swanson, B. E., Vawter, M. P., Williams, D., Wohnoutka, P., Zielke, H. R., Geschwind, D. H., Hof, P. R., Smith, S. M., Koch, C., Grant, S. G. N. & Jones, A. R., 2012, In : Nature. 489, 7416, p. 391-399 9 p.

    Research output: Contribution to journalArticle

  7. Arc requires PSD95 for assembly into postsynaptic complexes involved with brain disease and intelligence

    Fernandez, E., Collins, M. O., Frank, R. A. W., Zhu, F., Kopanitsa, M. V., Nithianantharajah, J., Lempriere, S., Fricker, D. G., Elsegood, K. A., McLaughlin, C., Croning, M. D. R., McLean, C., Armstrong, J. D., Hill, W. D., Deary, I., Cencelli, G., Bagni, C., Fromer, M., Purcell, S. M., Pocklington, A. J. & 3 others, Choudhary, J. S., Komiyama, N. & Grant, S., 17 Oct 2017, In : Cell Reports. 21, 3, p. 679-691

    Research output: Contribution to journalArticle

  8. Architecture of the Mouse Brain Synaptome

    Zhu, F., Cizeron, M., Qiu, Z., Benavides-piccione, R., Kopanitsa, M. V., Skene, N. G., Koniaris, B., Defelipe, J., Fransén, E., Komiyama, N. H. & Grant, S. G. N., 2 Aug 2018, In : Neuron.

    Research output: Contribution to journalArticle

  9. Association of Mouse Dlg4 (PSD-95) Gene Deletion and Human DLG4 Gene Variation With Phenotypes Relevant to Autism Spectrum Disorders and Williams' Syndrome

    Feyder, M., Karlsson, R-M., Mathur, P., Lyman, M., Bock, R., Momenan, R., Munasinghe, J., Scattoni, M. L., Ihne, J., Camp, M., Graybeal, C., Strathdee, D., Begg, A., Alvarez, V. A., Kirsch, P., Rietschel, M., Cichon, S., Walter, H., Meyer-Lindenberg, A., Grant, S. G. N. & 1 others, Holmes, A., Dec 2010, In : American Journal of Psychiatry. 167, 12, p. 1508-1517 10 p.

    Research output: Contribution to journalArticle

  10. Automated design of genomic Southern blot probes

    Croning, M. D. R., Fricker, D. G., Komiyama, N. H. & Grant, S. G. N., 2010, In : BMC Genomics. 11, p. 74

    Research output: Contribution to journalArticle

  11. Beta-adrenergic receptor activation rescues theta frequency stimulation-induced LTP deficits in mice expressing C-terminally truncated NMDA receptor GluN2A subunits

    Moody, T. D., Watabe, A. M., Indersmitten, T., Komiyama, N. H., Grant, S. G. N. & O'Dell, T. J., Feb 2011, In : Learning and Memory. 18, 2, p. 118-27 10 p.

    Research output: Contribution to journalArticle

  12. Bridging the translational divide: identical cognitive touchscreen testing in mice and humans carrying mutations in a disease-relevant homologous gene

    Nithianantharajah, J., McKechanie, A. G., Stewart, T. J., Johnstone, M., Blackwood, D. H., St Clair, D., Grant, S. G. N., Bussey, T. J. & Saksida, L. M., 1 Oct 2015, In : Scientific Reports. 5, p. 14613

    Research output: Contribution to journalArticle

  13. CYFIP1 Coordinates mRNA Translation and Cytoskeleton Remodeling to Ensure Proper Dendritic Spine Formation

    De Rubeis, S., Pasciuto, E., Li, K. W., Fernández, E., Di Marino, D., Buzzi, A., Ostroff, L. E., Klann, E., Zwartkruis, F. J. T., Komiyama, N. H., Grant, S. G. N., Poujol, C., Choquet, D., Achsel, T., Posthuma, D., Smit, A. B. & Bagni, C., 18 Sep 2013, In : Neuron. 79, 6, p. 1169-82 14 p.

    Research output: Contribution to journalArticle

  14. Calcium-permeable AMPA receptors and silent synapses in cocaine-conditioned place preference

    Shukla, A., Beroun, A., Panopoulou, M., Neumann, P. A., Grant, S. G., Olive, M. F., Dong, Y. & Schlüter, O. M., 11 Jan 2017, In : EMBO Journal.

    Research output: Contribution to journalArticle

  15. Canalization of genetic and pharmacological perturbations in developing primary neuronal activity patterns

    Charlesworth, P., Morton, A., Eglen, S. J., Komiyama, N. H. & Grant, S. G. N., 26 Jul 2015, In : Neuropharmacology.

    Research output: Contribution to journalArticle

  16. Cell‐type specific visualization and biochemical isolation of endogenous synaptic proteins in mice

    Zhu, F., Collins, M. O., Harmse, J., Choudhary, J. S., Grant, S. G. N. & Komiyama, N. H., 16 Oct 2019, In : European Journal of Neuroscience.

    Research output: Contribution to journalArticle

  17. Characterization of the proteome, diseases and evolution of the human postsynaptic density

    Bayes, A., Van De Lagemaat, L., Collins, M. O., Croning, M. D. R., Whittle, I. R., Choudhary, J. S. & Grant, S. G. N., Jan 2011, In : Nature Neuroscience. 14, 1, p. 19-21 3 p.

    Research output: Contribution to journalArticle

  18. Chronic treatment with a MEK inhibitor reverses enhanced excitatory field potentials in Syngap1 mice

    Kopanitsa, M. V., Gou, G., Afinowi, N. O., Bayés, À., Grant, S. G. N. & Komiyama, N. H., Aug 2018, In : Pharmacological reports. 70, 4, p. 777-783 7 p.

    Research output: Contribution to journalArticle

  19. Cognitive components in mice and humans: Combining genetics and touchscreens for medical translation

    Nithianantharajah, J. & Grant, S. G. N., Oct 2013, In : Neurobiology of Learning and Memory. 105, p. 13-19 7 p.

    Research output: Contribution to journalArticle

  20. Comparative Study of Human and Mouse Postsynaptic Proteomes Finds High Compositional Conservation and Abundance Differences for Key Synaptic Proteins

    Bayes, A., Collins, M. O., Croning, M. D. R., Van De Lagemaat, L., Choudhary, J. S. & Grant, S. G. N., 5 Oct 2012, In : PLoS ONE. 7, 10, p. - 13 p., e46683.

    Research output: Contribution to journalArticle

  21. Comprehensive behavioral analysis of heterozygous Syngap1knockout mice

    Nakajima, R., Takao, K., Hattori, S., Shoji, H., Komiyama, N. H., Grant, S. G. N. & Miyakawa, T., 19 Jul 2019, In : Neuropsychopharmacology Reports.

    Research output: Contribution to journalArticle

  22. Computational geometry analysis of dendritic spines by structured illumination microscopy

    Kashiwagi, Y., Higashi, T., Obashi, K., Sato, Y., Komiyama, N. H., Grant, S. G. N. & Okabe, S., 20 Mar 2019, In : Nature Communications. 10, 1

    Research output: Contribution to journalArticle

  23. Convergence of hippocampal pathophysiology in Syngap+/- and Fmr1-/y mice

    Barnes, S., Wijetunge, L., Jackson, A. D., Katsanevaki, D., Osterweil, E., Komiyama, N., Grant, S., Bear, M. F., Nägerl, U. V., Kind, P. & Wyllie, D., 11 Nov 2015, In : Journal of Neuroscience. 35, 45, p. 15073-15081

    Research output: Contribution to journalArticle

  24. De novo CNV analysis implicates specific abnormalities of postsynaptic signalling complexes in the pathogenesis of schizophrenia

    Kirov, G., Pocklington, A. J., Holmans, P., Ivanov, D., Ikeda, M., Ruderfer, D., Moran, J., Chambert, K., Toncheva, D., Georgieva, L., Grozeva, D., Fjodorova, M., Wollerton, R., Rees, E., Nikolov, I., Van De Lagemaat, L., Bayés, A., Fernandez, E., Olason, P. I., Böttcher, Y. & 10 others, Komiyama, N. H., Collins, M. O., Choudhary, J., Stefansson, K., Stefansson, H., Grant, S. G. N., Purcell, S., Sklar, P., O'Donovan, M. C. & Owen, M. J., Feb 2012, In : Molecular Psychiatry. 17, 2, p. 142-153 12 p.

    Research output: Contribution to journalArticle

  25. De novo mutations in schizophrenia implicate synaptic networks

    Fromer, M., Pocklington, A. J., Kavanagh, D. H., Williams, H. J., Dwyer, S., Gormley, P., Georgieva, L., Rees, E., Palta, P., Ruderfer, D. M., Carrera, N., Humphreys, I., Johnson, J. S., Roussos, P., Barker, D. D., Banks, E., Milanova, V., Grant, S. G., Hannon, E., Rose, S. A. & 12 others, Chambert, K., Mahajan, M., Scolnick, E. M., Moran, J. L., Kirov, G., Palotie, A., McCarroll, S. A., Holmans, P., Sklar, P., Owen, M. J., Purcell, S. M. & O'Donovan, M. C., 13 Feb 2014, In : Nature. 506, 7487, p. 179-+ 16 p.

    Research output: Contribution to journalArticle

  26. Dlg3 Trafficking and Apical Tight Junction Formation Is Regulated by Nedd4 and Nedd4-2 E3 Ubiquitin Ligases

    Van Campenhout, C. A., Eitelhuber, A., Gloeckner, C. J., Giallonardo, P., Gegg, M., Oller, H., Grant, S. G. N., Krappmann, D., Ueffing, M. & Lickert, H., 13 Sep 2011, In : Developmental Cell. 21, 3, p. 479-491 13 p.

    Research output: Contribution to journalArticle

  27. Dlgap1 knockout mice exhibit alterations of the postsynaptic density and selective reductions in sociability

    Coba, M. P., Ramaker, M. J., Ho, E. V., Thompson, S. L., Komiyama, N. H., Grant, S. G. N., Knowles, J. A. & Dulawa, S. C., 2 Feb 2018, In : Scientific Reports. 8, 1

    Research output: Contribution to journalArticle

  28. Durable fear memories require PSD-95

    Fitzgerald, P. J., Pinard, C. R., Camp, M. C., Feyder, M., Sah, A., Bergstrom, H. C., Graybeal, C., Liu, Y., Schlüter, O. M., Grant, S. G., Singewald, N., Xu, W. & Holmes, A., Jul 2015, In : Molecular Psychiatry. 20, 7, p. 901-12 12 p.

    Research output: Contribution to journalArticle

  29. Efficient linkage of 10 loci in the proximal region of the mouse X chromosome

    Mullins, L. J., Stephenson, D. A., Grant, S. G. & Chapman, V. M., May 1990, In : Genomics. 7, 1, p. 19-30 12 p.

    Research output: Contribution to journalArticle

  30. Enhanced cognition and dysregulated hippocampal synaptic physiology in mice with a heterozygous deletion of PSD-95

    Horner, A. E., McLaughlin, C. L., Afinowi, N. O., Bussey, T. J., Saksida, L. M., Komiyama, N. H., Grant, S. G. N. & Kopanitsa, M. V., 13 Dec 2017, In : European Journal of Neuroscience.

    Research output: Contribution to journalArticle

  31. Evolution of GluN2A/B cytoplasmic domains diversified vertebrate synaptic plasticity and behavior

    Ryan, T. J., Kopanitsa, M. V., Indersmitten, T., Nithianantharajah, J., Afinowi, N. O., Pettit, C., Stanford, L. E., Sprengel, R., Saksida, L. M., Bussey, T. J., O'Dell, T. J., Grant, S. G. N. & Komiyama, N., 2013, In : Nature Neuroscience. 16, 1, p. 25-32 8 p.

    Research output: Contribution to journalArticle

  32. Evolution of NMDA receptor cytoplasmic interaction domains: implications for organisation of synaptic signalling complexes

    Ryan, T. J., Emes, R. D., Grant, S. G. & Komiyama, N. H., 2008, In : BMC Neuroscience. 9, p. 6

    Research output: Contribution to journalArticle

  33. Evolution of Synapse Complexity and Diversity

    Emes, R. D. & Grant, S. G. N., 2012, ANNUAL REVIEW OF NEUROSCIENCE, VOL 35. Hyman, SE. (ed.). PALO ALTO: ANNUAL REVIEWS, p. 111-131 21 p. (Annual Review of Neuroscience; vol. 35).

    Research output: Chapter in Book/Report/Conference proceedingChapter

  34. Evolution of complexity in the zebrafish synapse proteome

    Bayés, À., Collins, M. O., Reig-viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J. S., Emes, R. D. & Grant, S. G. N., 2 Mar 2017, In : Nature Communications. 8, 14613.

    Research output: Contribution to journalArticle

  35. Evolution of the synapse proteome

    Armstrong, J. D., Malik, B., Pocklington, A., Emes, R. & Grant, S., 2009, In : Journal of neurogenetics. 23, p. S34-S35 2 p.

    Research output: Contribution to journalMeeting abstract

  36. Evolutionary expansion and anatomical specialization of synapse proteome complexity

    Emes, R. D., Pocklington, A. J., Anderson, C. N. G., Bayes, A., Collins, M. O., Vickers, C. A., Croning, M. D. R., Malik, B. R., Choudhary, J. S., Armstrong, D. & Grant, S., Jul 2008, In : Nature Neuroscience. 11, 7, p. 799-806 8 p.

    Research output: Contribution to journalArticle

  37. FAK is required for axonal sorting by Schwann cells

    Grove, M., Komiyama, N. H., Nave, K-A., Grant, S. G., Sherman, D. L. & Brophy, P. J., 2007, In : The Journal of Cell Biology. 176, 3, p. 277-82 6 p.

    Research output: Contribution to journalArticle

  38. G2Cdb: the Genes to Cognition database

    Croning, M. D. R., Marshall, M. C., McLaren, P., Armstrong, J. D. & Grant, S. G. N., Jan 2009, In : Nucleic Acids Research. 37, p. D846-D851 6 p.

    Research output: Contribution to journalArticle

  39. Genetic Dissection Of Cognition In Humans And Mice Carrying Mutations: Evidence That Vertebrate Genomic Evolution Produced Susceptibility To Mental Illnesses

    Nithianantharajah, J., McKechanie, A., Komiyama, N., Emes, R. D., Saksida, L. M., Bussey, T. J. & Grant, S., 18 Jul 2012, p. 641.

    Research output: Contribution to conferencePoster

  40. Genome variation and complexity in the autism spectrum

    van de Lagemaat, L. N. & Grant, S. G. N., 15 Jul 2010, In : Neuron. 67, 1, p. 8-10 3 p.

    Research output: Contribution to journalArticle

  41. Haploinsufficiency of EHMT1 improves pattern separation and increases hippocampal cell proliferation

    Benevento, M., Oomen, C. A., Horner, A. E., Amiri, H., Jacobs, T., Pauwels, C., Frega, M., Kleefstra, T., Kopanitsa, M. V., Grant, S., Bussey, T. J., Saksida, L. M., Van der Zee, C. E. E. M., van Bokhoven, H., Glennon, J. C. & Kasri, N. N., 10 Jan 2017, In : Scientific Reports.

    Research output: Contribution to journalArticle

  42. Hierarchical organisation and genetically separable subfamilies of PSD95 postsynaptic supercomplexes

    Frank, R. A. W., Zhu, F., Komiyama, N. H. & Grant, S. G. N., 28 Apr 2017, In : Journal of Neurochemistry.

    Research output: Contribution to journalArticle

  43. Human cognitive ability is influenced by genetic variation in components of postsynaptic signaling complexes assembled by MAGUK proteins

    Hill, W. D., Davies, G., Van de Lagemaat, L., Christoforou, A., Fernandes, C., Liewald, D., Croning, M., Payton, A., Craig, L., Whalley, L., Horan, M., Ollier, W., Hansell, N., Wright, M., Martin, N. G., Montgomery, G., Steen, V., Le Hellard, S., Espeseth, T., Lundervold, A. & 6 others, Reinvang, I., Starr, J., Pendleton, N., Grant, S., Bates, T. & Deary, I., Nov 2013, In : Behavior Genetics. 43, 6, p. 521-522 2 p.

    Research output: Contribution to journalMeeting abstract

  44. Human cognitive ability is influenced by genetic variation in components of postsynaptic signalling complexes assembled by NMDA receptors and MAGUK proteins

    Hill, W. D., Davies, G., Van De Lagemaat, L., Christoforou, A., Marioni, R. E., Fernandes, C. P. D., Liewald, D. C., Croning, M. D. R., Payton, A., Craig, L. C. A., Whalley, L. J., Horan, M., Ollier, W., Hansell, N. K., Wright, M. J., Martin, N. G., Montgomery, G. W., Steen, V. M., Le Hellard, S., Espeseth, T. & 7 others, Lundervold, A. J., Reinvang, I., Starr, J. M., Pendleton, N., Grant, S. G. N., Bates, T. C. & Deary, I. J., 7 Jan 2014, In : Translational Psychiatry. 4, 1, 8 p., 341.

    Research output: Contribution to journalArticle

  45. Human post-mortem synapse proteome integrity screening for proteomic studies of postsynaptic complexes

    Bayés, A., Collins, M. O., Galtrey, C. M., Simonnet, C., Roy, M., Croning, M., Gou, G., van de Lagemaat, L. N., Milward, D., Whittle, I. R., Smith, C., Choudhary, J. S. & Grant, S., 28 Nov 2014, In : Molecular brain research. 7, 1, p. 88

    Research output: Contribution to journalArticle

  46. INTEGRINS CONTRIBUTE TO THE AXOGLIAL INTERACTIONS THAT INITIATE MYELINATION IN THE CNS

    Nunes-Fonseca, C., Camara, J., Wang, Z., Friedman, H. C., Grove, M., Sherman, D. L., Komiyama, N. H., Grant, S. G., Brophy, P. J., Peterson, A. & Ffrench-Constant, C., Oct 2009, In : Glia. 57, 13, p. S42-S42 1 p.

    Research output: Contribution to journalMeeting abstract

  47. Identification of vulnerable cell types in major brain disorders using single cell transcriptomes and expression weighted cell type enrichment

    Skene, N. G. & Grant, S. G. N., 27 Jan 2016, In : Frontiers in Neuroscience. 10, JAN, 16.

    Research output: Contribution to journalArticle

  48. In vivo STED microscopy visualizes morphological changes of large PSD95 assemblies over several hours in the mouse visual cortex

    Wegner, W., Mott, A. C., Grant, S., Steffens, H. & Willig, K. I., 9 Jan 2018, In : Scientific Reports.

    Research output: Contribution to journalArticle

  49. Integrin-mediated axoglial interactions initiate myelination in the central nervous system

    Câmara, J., Wang, Z., Nunes-Fonseca, C., Friedman, H. C., Grove, M., Sherman, D. L., Komiyama, N. H., Grant, S. G., Brophy, P. J., Peterson, A. & ffrench-Constant, C., May 2009, In : The Journal of Cell Biology. 185, 4, p. 699-712 14 p.

    Research output: Contribution to journalArticle

  50. Multilocus molecular mapping of the mouse X chromosome

    Mullins, L. J., Grant, S. G., Stephenson, D. A. & Chapman, V. M., Oct 1988, In : Genomics. 3, 3, p. 187-94 8 p.

    Research output: Contribution to journalArticle

  51. Mutant mice and neuroscience: Recommendations concerning genetic background

    Silva, A. J., Simpson, E. M., Takahashi, J. S., Lipp, H. P., Nakanishi, S., Wehner, J. M., Giese, K. P., Tully, T., Abel, T., Chapman, P. F., Fox, K., Grant, S., Itohara, S., Lathe, R., Mayford, M., McNamara, J. O., Morris, R. J., Picciotto, M., Roder, J., Shin, H. S. & 6 others, Slesinger, P. A., Storm, D. R., Stryker, M. P., Tonegawa, S., Wang, Y. & Wolfer, D. P., 1997, In : Neuron. 19, 4, p. 755-759 5 p.

    Research output: Contribution to journalComment/debate

  52. NMDA receptor modulation of glutamate release in activated neutrophils

    Del Arroyo, A. G., Hadjihambi, A., Sanchez, J., Turovsky, E., Kasymov, V., Cain, D., Nightingale, T. D., Lambden, S., Grant, S. G. N., Gourine, A. V. & Ackland, G. L., 8 Aug 2019, In : EBioMedicine.

    Research output: Contribution to journalArticle

  53. NMDA receptor subunits and associated signaling molecules mediating antidepressant-related effects of NMDA-GluN2B antagonism

    Kiselycznyk, C., Jury, N. J., Halladay, L. R., Nakazawa, K., Mishina, M., Sprengel, R., Grant, S. G. N., Svenningsson, P. & Holmes, A., 1 Jul 2015, In : Behavioural Brain Research. 287, p. 89-95 7 p.

    Research output: Contribution to journalArticle

  54. NMDA receptors are selectively partitioned into complexes and supercomplexes during synapse maturation

    Frank, R. A. W., Komiyama, N. H., Ryan, T. J., Zhu, F., O'Dell, T. J. & Grant, S. G. N., 27 Apr 2016, In : Nature Communications. 7, p. 11264

    Research output: Contribution to journalArticle

  55. Neurobeachin Regulates Glutamate- and GABA-Receptor Targeting to Synapses via Distinct Pathways

    Farzana, F., Zalm, R., Chen, N., Li, K. W., Grant, S. G. N., Smit, A. B., Toonen, R. F. & Verhage, M., 2 May 2016, In : Molecular Neurobiology. 53, 4, p. 2112-2123 12 p.

    Research output: Contribution to journalArticle

  56. Neurotransmitters Drive Combinatorial Multistate Postsynaptic Density Networks

    Coba, M. P., Pocklington, A. J., Collins, M. O., Kopanitsa, M. V., Uren, R. T., Swamy, S., Croning, M. D. R., Choudhary, J. S. & Grant, S. G. N., Apr 2009, In : Science Signaling. 2, 68, ra19.

    Research output: Contribution to journalArticle

  57. Novel MPDZ/MUPP1 transgenic and knockdown models confirm Mpdz's role in ethanol withdrawal and support its role in voluntary ethanol consumption

    Milner, L. C., Shirley, R. L., Kozell, L. B., Walter, N. A., Kruse, L. C., Komiyama, N. H., Grant, S. G. N. & Buck, K. J., Jan 2015, In : Addiction Biology. 20, 1, p. 143-147 5 p.

    Research output: Contribution to journalArticle

  58. Objective measurement of physical activity and sedentary behaviour: review with new data

    Reilly, J. J., Penpraze, V., Hislop, J., Davies, G., Grant, S. & Paton, J. Y., Jul 2008, In : Archives of Disease in Childhood. 93, 7, p. 614-619 6 p.

    Research output: Contribution to journalLiterature review

  59. Organization of brain complexity--synapse proteome form and function

    Pocklington, A. J., Armstrong, J. D. & Grant, S. G. N., 2006, In : Briefings in functional genomics & proteomics. 5, 1, p. 66-73 8 p.

    Research output: Contribution to journalArticle

  60. PSD-95 Is Essential for Hallucinogen and Atypical Antipsychotic Drug Actions at Serotonin Receptors

    Abbas, A. I., Yadav, P. N., Yao, W-D., Arbuckle, M. I., Grant, S. G. N., Caron, M. G. & Roth, B. L., 3 Jun 2009, In : Journal of Neuroscience. 29, 22, p. 7124-7136 13 p.

    Research output: Contribution to journalArticle

  61. PSD95 nanoclusters are postsynaptic building blocks in hippocampus circuits

    Broadhead, M. J., Horrocks, M. H., Zhu, F., Muresan, L., Benavides-Piccione, R., DeFelipe, J., Fricker, D., Kopanitsa, M. V., Duncan, R. R., Klenerman, D., Komiyama, N. H., Lee, S. F. & Grant, S. G. N., 25 Apr 2016, In : Scientific Reports. 6, p. 24626

    Research output: Contribution to journalArticle

  62. Probing the Modulation of Acute Ethanol Intoxication by Pharmacological Manipulation of the NMDAR Glycine Co-Agonist Site

    DeBrouse, L., Hurd, B., Kiselycznyk, C., Plitt, A., Todaro, A., Mishina, M., Grant, S. G. N., Camp, M., Gunduz-Cinar, O. & Holmes, A., Feb 2013, In : Alcoholism-Clinical and experimental research. 37, 2, p. 223-233 11 p.

    Research output: Contribution to journalArticle

  63. Proteomic analysis of postsynaptic proteins in regions of the human neocortex

    Roy, M., Sorokina, O., Skene, N., Simonnet, C., Mazzola, F., Zwart, R., Sher, E., Smith, C., Armstrong, J. D. & Grant, S., 4 Dec 2017, In : Nature Neuroscience.

    Research output: Contribution to journalArticle

  64. Quantitative differences in developmental profiles of spontaneous activity in cortical and hippocampal cultures

    Charlesworth, P., Cotterill, E., Morton, A., Grant, S. G. N. & Eglen, S. J., 28 Jan 2015, In : Neural Development. 10, p. 1

    Research output: Contribution to journalArticle

  65. Rapid homeostatic downregulation of LTP by extrasynaptic GluN2B receptors

    Delgado, J. Y., Fink, A. E., Grant, S. G. N., O'Dell, T. J. & Opazo, P., Nov 2018, In : Journal of Neurophysiology.

    Research output: Contribution to journalArticle

  66. Reconstructing protein complexes: From proteomics to systems biology

    Armstrong, J. D., Pocklington, A. J., Cumiskey, M. A. & Grant, S. G. N., 2006, In : Proteomics. 6, 17, p. 4724-4731 8 p.

    Research output: Contribution to journalArticle

  67. Regional Diversity in the Postsynaptic Proteome of the Mouse Brain

    Roy, M., Sorokina, O., McLean, C., Tapia-González, S., DeFelipe, J., Armstrong, J. D. & Grant, S., 1 Aug 2018, In : Proteomes. 6, 3, 18 p.

    Research output: Contribution to journalArticle

  68. Regional localization of the murine Duchenne muscular dystrophy gene on the mouse X chromosome

    Chamberlain, J. S., Grant, S. G., Reeves, A. A., Mullins, L. J., Stephenson, D. A., Hoffman, E. P., Monaco, A. P., Kunkel, L. M., Caskey, C. T. & Chapman, V. M., Nov 1987, In : Somatic Cell and Molecular Genetics. 13, 6, p. 671-8 8 p.

    Research output: Contribution to journalArticle

  69. Selectivity, efficacy and toxicity studies of UCCB01-144, a dimeric neuroprotective PSD-95 inhibitor

    Bach, A., Clausen, B. H., Kristensen, L. K., Andersen, M. G., Ellman, D. G., Hansen, P. B. L., Hasseldam, H., Heitz, M., Özcelik, D., Tuck, E. J., Kopanitsa, M. V., Grant, S. G. N., Lykke-hartmann, K., Johansen, F. F., Lambertsen, K. L. & Strømgaard, K., 15 May 2019, In : Neuropharmacology. 150

    Research output: Contribution to journalArticle

  70. Separable features of visual cortical plasticity revealed by N-methyl-D-aspartate receptor 2A signaling

    Fagiolini, M., Katagiri, H., Miyamoto, H., Mori, H., Grant, S. G. N., Mishina, M. & Hensch, T. K., 4 Mar 2003, In : Proceedings of the National Academy of Sciences. 100, 5, p. 2854-9 6 p.

    Research output: Contribution to journalArticle

  71. SnapShot: Organizational principles of the postsynaptic proteome

    Grant, S. G. N., 16 Oct 2013, In : Neuron. 80, 2, p. 534.e1

    Research output: Contribution to journalArticle

  72. Specific deletion of focal adhesion kinase suppresses tumor formation and blocks malignant progression

    McLean, G. W., Komiyama, N. H., Serrels, B., Asano, H., Reynolds, L., Conti, F., Hodivala-Dilke, K., Metzger, D., Chambon, P., Grant, S. G. N. & Frame, M. C., 15 Dec 2004, In : Genes & Development. 18, 24, p. 2998-3003 6 p.

    Research output: Contribution to journalArticle

  73. Standardised experiments in mutant mice reveal behavioural similarity on 129S5 and C57BL/6J backgrounds

    van de Lagemaat, L. N., Stanford, L. E., Pettit, C., Strathdee, D. J., Strathdee, K. E., Elsegood, K. A., Fricker, D. G., Croning, M. D. R., Komiyama, N. H. & Grant, S. G. N., 25 Nov 2016, In : Genes Brain and Behavior.

    Research output: Contribution to journalArticle

  74. Supramolecular organization of NMDA receptors and the postsynaptic density

    Frank, R. A. & Grant, S. G., Aug 2017, In : Current Opinion in Neurobiology. 45, p. 139-147 9 p.

    Research output: Contribution to journalArticle

  75. SynGAP isoforms exert opposing effects on synaptic strength

    McMahon, A. C., Barnett, M. W., O'Leary, T. S., Stoney, P. N., Collins, M. O., Papadia, S., Choudhary, J. S., Komiyama, N. H., Grant, S. G. N., Hardingham, G. E., Wyllie, D. J. A. & Kind, P. C., Jun 2012, In : Nature Communications. 3, 9 p., 900.

    Research output: Contribution to journalArticle

  76. SynGAP regulates ERK/MAPK signaling, synaptic plasticity, and learning in the complex with postsynaptic density 95 and NMDA receptor

    Komiyama, N. H., Watabe, A. M., Carlisle, H. J., Porter, K., Charlesworth, P., Monti, J., Strathdee, D. J. C., O'Carroll, C. M., Martin, S. J., Morris, R. G. M., O'Dell, T. J. & Grant, S. G. N., 15 Nov 2002, In : Journal of Neuroscience. 22, 22, p. 9721-32 12 p.

    Research output: Contribution to journalArticle

  77. SynSysNet: integration of experimental data on synaptic protein-protein interactions with drug-target relations

    von Eichborn, J., Dunkel, M., Gohlke, B. O., Preissner, S. C., Hoffmann, M. F., Bauer, J. M. J., Armstrong, D., Schaefer, M. H., Andrade-Navarro, M. A., Le Novere, N., Croning, M. D. R., Grant, S. G. N., van Nierop, P., Smit, A. B. & Preissner, R., Jan 2013, In : Nucleic Acids Research. 41, D1, p. D834-D840 7 p.

    Research output: Contribution to journalArticle

  78. Synapse diversity and synaptome architecture in human genetic disorders

    Grant, S. G. N., 26 Jul 2019, In : Human Molecular Genetics.

    Research output: Contribution to journalReview article

  79. Synapse molecular complexity and the plasticity-behaviour problem

    Grant, S., 15 Nov 2018, In : Brain and Neuroscience Advances.

    Research output: Contribution to journalArticle

  80. Synapse proteomics of multiprotein complexes: en route from genes to nervous system diseases

    Grant, S. G. N., Marshall, M. C., Page, K-L., Cumiskey, M. A. & Armstrong, J. D., 2005, In : Human Molecular Genetics. 14, suppl 2, p. R225-R234 10 p.

    Research output: Contribution to journalArticle

  81. Synapse-associated protein 102/dlgh3 couples the NMDA receptor to specific plasticity pathways and learning strategies

    Cuthbert, P. C., Stanford, L. E., Coba, M. P., Ainge, J. A., Fink, A. E., Opazo, P., Delgado, J. Y., Komiyama, N. H., O'Dell, T. J. & Grant, S. G. N., 7 Mar 2007, In : Journal of Neuroscience. 27, 10, p. 2673-82 10 p.

    Research output: Contribution to journalArticle

  82. Synaptic Ras GTPase activating protein regulates pattern formation in the trigeminal system of mice

    Barnett, M. W., Watson, R. F., Vitalis, T., Porter, K., Komiyama, N. H., Stoney, P. N., Gillingwater, T. H., Grant, S. G. N. & Kind, P. C., 2006, In : Journal of Neuroscience. 26, 5, p. 1355-65 11 p.

    Research output: Contribution to journalArticle

  83. Synaptic scaffold evolution generated components of vertebrate cognitive complexity

    Nithianantharajah, J., Komiyama, N., McKechanie, A., Johnstone, M., Blackwood, D. H., Clair, D. S., Emes, R. D., van de Lagemaat, L. N., Saksida, L. M., Bussey, T. J. & Grant, S. G. N., Jan 2013, In : Nature Neuroscience. 16, 1, p. 16-24 9 p.

    Research output: Contribution to journalArticle

  84. Synaptopathies: diseases of the synaptome

    Grant, S. G., 2012, In : Current Opinion in Neurobiology.

    Research output: Contribution to journalArticle

  85. Synaptopathy - From biology to therapy

    Grant, S. G. N., Bagni, C. & O'Dell, T. J., 1 Jan 2016, In : Neuropharmacology. 100, p. 1 1 p.

    Research output: Contribution to journalEditorial

  86. TNiK Is Required for Postsynaptic and Nuclear Signaling Pathways and Cognitive Function

    Coba, M. P., Komiyama, N. H., Nithianantharajah, J., Kopanitsa, M. V., Indersmitten, T., Skene, N. G., Tuck, E. J., Fricker, D. G., Elsegood, K. A., Stanford, L. E., Afinowi, N. O., Saksida, L. M., Bussey, T. J., O'Dell, T. J. & Grant, S. G. N., 3 Oct 2012, In : Journal of Neuroscience. 32, 40, p. 13987-13999 13 p.

    Research output: Contribution to journalArticle

  87. Targeted tandem affinity purification of PSD-95 recovers core postsynaptic complexes and schizophrenia susceptibility proteins

    Fernandez, E., Collins, M. O., Uren, R. T., Kopanitsa, M. V., Komiyama, N. H., Croning, M. D. R., Zografos, L., Armstrong, J. D., Choudhary, J. S. & Grant, S. G. N., May 2009, In : Molecular Systems Biology. 5, p. - 17 p., 269.

    Research output: Contribution to journalArticle

  88. The Organization and integrative function of the post-synaptic proteome

    Grant, S., Husi, H., Choudhary, J., Cumiskey, M., Blackstock, W. & Armstrong, D., 2004, Excitatory-Inhibitory Balance: Synapses, Circuits, Systems. KLUWER ACADEMIC/PLENUM PUBL, p. 13-44 32 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

  89. The SH3 domain of postsynaptic density 95 mediates inflammatory pain through phosphatidylinositol-3-kinase recruitment

    Arbuckle, M. I., Komiyama, N. H., Delaney, A., Coba, M., Garry, E. M., Rosie, R., Allchorne, A. J., Forsyth, L. H., Bence, M., Carlisle, H. J., O'Dell, T. J., Mitchell, R., Fleetwood-Walker, S. M. & Grant, S., Jun 2010, In : EMBO Reports. 11, 6, p. 473-478 6 p.

    Research output: Contribution to journalArticle

  90. The Subtype of GluN2 C-terminal Domain Determines the Response to Excitotoxic Insults

    Martel, M-A., Ryan, T. J., Bell, K. F. S., Fowler, J. H., McMahon, A., Al-Mubarak, B., Komiyama, N., Horsburgh, K., Kind, P. C., Grant, S. G. N., Wyllie, D. J. A. & Hardingham, G. E., May 2012, In : Neuron. 74, 3, p. 543-556 14 p.

    Research output: Contribution to journalArticle

  91. The Synaptomic Theory of Behavior and Brain Disease

    Grant, S. G. N., 18 Mar 2019, In : Cold Spring Harbor Symposia on Quantitative Biology. p. 037887

    Research output: Contribution to journalArticle

  92. The association between cognitive abilities and the postsynaptic proteome of central excitatory synapses

    Hill, W. D., Davies, G., Croning, M., Payton, A., Craig, L., Horan, M., Ollier, WI., Starr, J., Pendleton, N., Grant, S., Bates, T. & Deary, I., Nov 2012, In : Behavior Genetics. 42, 6, p. 938-938 1 p.

    Research output: Contribution to journalMeeting abstract

  93. The molecular evolution of the vertebrate behavioural repertoire

    Grant, S. G. N., 5 Jan 2016, In : Philosophical Transactions of the Royal Society B: Biological Sciences. 371, 1685, 20150051.

    Research output: Contribution to journalArticle

  94. The proteomes of neurotransmitter receptor complexes form modular networks with distributed functionality underlying plasticity and behaviour

    Pocklington, A. J., Cumiskey, M., Armstrong, J. D. & Grant, S. G. N., 17 Jan 2006, In : Molecular Systems Biology. 2, 14 p., 2006.0023.

    Research output: Contribution to journalArticle

  95. Thigh-Length Versus Below-Knee Stockings for Deep Venous Thrombosis Prophylaxis After Stroke: A Randomized Trial

    Dennis, M., Cranswick, G., Deary, A., Fraser, A., Graham, C., Grant, S., Gunkel, A., Hunter, J., MacRae, A., Perry, D., Soosay, V., Williams, C., Williamson, A., Young, A., Sandercock, P., Reid, J., Murray, G., Venables, G., Rudd, A., Bowler, G. & 10 others, Celani, M. G., Ricci, S., Lindley, R., Hautvast, M., Paterson, M., Ting, T., Baigent, C., Bamford, J., Slattery, J. & CLOTS Trial Collaborat, 2 Nov 2010, In : Annals of Internal Medicine. 153, 9, p. 553-562 10 p.

    Research output: Contribution to journalArticle

  96. Tolerance to ethanol intoxication after chronic ethanol: role of GluN2A and PSD-95

    Daut, R. A., Busch, E. F., Ihne, J., Fisher, D., Mishina, M., Grant, S. G. N., Camp, M. & Holmes, A., Mar 2015, In : Addiction Biology. 20, 2, p. 259-262 4 p.

    Research output: Contribution to journalArticle

  97. X-chromosome gene order in different Mus species crosses

    Stephenson, D. A., Grant, S. G., Mullins, L. J., Scolese, A. E., O'Reilly, A. J. & Chapman, V. M., 1988, In : Current topics in microbiology and immunology. 137, p. 18-24 7 p.

    Research output: Contribution to journalArticle