Edinburgh Research Explorer

Prof Seth Grant

Personal Chair of Molecular Neuroscience

  1. 2019
  2. Selectivity, efficacy and toxicity studies of UCCB01-144, a dimeric neuroprotective PSD-95 inhibitor

    Bach, A., Clausen, B. H., Kristensen, L. K., Andersen, M. G., Ellman, D. G., Hansen, P. B. L., Hasseldam, H., Heitz, M., Özcelik, D., Tuck, E. J., Kopanitsa, M. V., Grant, S. G. N., Lykke-hartmann, K., Johansen, F. F., Lambertsen, K. L. & Strømgaard, K., 15 May 2019, In : Neuropharmacology. 150

    Research output: Contribution to journalArticle

  3. Computational geometry analysis of dendritic spines by structured illumination microscopy

    Kashiwagi, Y., Higashi, T., Obashi, K., Sato, Y., Komiyama, N. H., Grant, S. G. N. & Okabe, S., 20 Mar 2019, In : Nature Communications. 10, 1

    Research output: Contribution to journalArticle

  4. The Synaptomic Theory of Behavior and Brain Disease

    Grant, S. G. N., 18 Mar 2019, In : Cold Spring Harbor Symposia on Quantitative Biology. p. 037887

    Research output: Contribution to journalArticle

  5. 2018
  6. Synapse molecular complexity and the plasticity-behaviour problem

    Grant, S., 15 Nov 2018, In : Brain and Neuroscience Advances.

    Research output: Contribution to journalArticle

  7. Rapid homeostatic downregulation of LTP by extrasynaptic GluN2B receptors

    Delgado, J. Y., Fink, A. E., Grant, S. G. N., O'Dell, T. J. & Opazo, P., Nov 2018, In : Journal of Neurophysiology.

    Research output: Contribution to journalArticle

  8. Architecture of the Mouse Brain Synaptome

    Zhu, F., Cizeron, M., Qiu, Z., Benavides-piccione, R., Kopanitsa, M. V., Skene, N. G., Koniaris, B., Defelipe, J., Fransén, E., Komiyama, N. H. & Grant, S. G. N., 2 Aug 2018, In : Neuron.

    Research output: Contribution to journalArticle

  9. Regional Diversity in the Postsynaptic Proteome of the Mouse Brain

    Roy, M., Sorokina, O., McLean, C., Tapia-González, S., DeFelipe, J., Armstrong, J. D. & Grant, S., 1 Aug 2018, In : Proteomes. 6, 3, 18 p.

    Research output: Contribution to journalArticle

  10. Chronic treatment with a MEK inhibitor reverses enhanced excitatory field potentials in Syngap1 mice

    Kopanitsa, M. V., Gou, G., Afinowi, N. O., Bayés, À., Grant, S. G. N. & Komiyama, N. H., Aug 2018, In : Pharmacological reports. 70, 4, p. 777-783 7 p.

    Research output: Contribution to journalArticle

  11. Dlgap1 knockout mice exhibit alterations of the postsynaptic density and selective reductions in sociability

    Coba, M. P., Ramaker, M. J., Ho, E. V., Thompson, S. L., Komiyama, N. H., Grant, S. G. N., Knowles, J. A. & Dulawa, S. C., 2 Feb 2018, In : Scientific Reports. 8, 1

    Research output: Contribution to journalArticle

  12. In vivo STED microscopy visualizes morphological changes of large PSD95 assemblies over several hours in the mouse visual cortex

    Wegner, W., Mott, A. C., Grant, S., Steffens, H. & Willig, K. I., 9 Jan 2018, In : Scientific Reports.

    Research output: Contribution to journalArticle

  13. 2017
  14. Enhanced cognition and dysregulated hippocampal synaptic physiology in mice with a heterozygous deletion of PSD-95

    Horner, A. E., McLaughlin, C. L., Afinowi, N. O., Bussey, T. J., Saksida, L. M., Komiyama, N. H., Grant, S. G. N. & Kopanitsa, M. V., 13 Dec 2017, In : European Journal of Neuroscience.

    Research output: Contribution to journalArticle

  15. Proteomic analysis of postsynaptic proteins in regions of the human neocortex

    Roy, M., Sorokina, O., Skene, N., Simonnet, C., Mazzola, F., Zwart, R., Sher, E., Smith, C., Armstrong, J. D. & Grant, S., 4 Dec 2017, In : Nature Neuroscience.

    Research output: Contribution to journalArticle

  16. Arc requires PSD95 for assembly into postsynaptic complexes involved with brain disease and intelligence

    Fernandez, E., Collins, M. O., Frank, R. A. W., Zhu, F., Kopanitsa, M. V., Nithianantharajah, J., Lempriere, S., Fricker, D. G., Elsegood, K. A., McLaughlin, C., Croning, M. D. R., McLean, C., Armstrong, J. D., Hill, W. D., Deary, I., Cencelli, G., Bagni, C., Fromer, M., Purcell, S. M., Pocklington, A. J. & 3 othersChoudhary, J. S., Komiyama, N. & Grant, S., 17 Oct 2017, In : Cell Reports. 21, 3, p. 679-691

    Research output: Contribution to journalArticle

  17. A genomic lifespan program that reorganises the young adult brain is targeted in schizophrenia

    Skene, N. G., Roy, M. & Grant, S. G., 12 Sep 2017, In : eLIFE. 6

    Research output: Contribution to journalArticle

  18. Supramolecular organization of NMDA receptors and the postsynaptic density

    Frank, R. A. & Grant, S. G., Aug 2017, In : Current Opinion in Neurobiology. 45, p. 139-147 9 p.

    Research output: Contribution to journalArticle

  19. Hierarchical organisation and genetically separable subfamilies of PSD95 postsynaptic supercomplexes

    Frank, R. A. W., Zhu, F., Komiyama, N. H. & Grant, S. G. N., 28 Apr 2017, In : Journal of Neurochemistry.

    Research output: Contribution to journalArticle

  20. Evolution of complexity in the zebrafish synapse proteome

    Bayés, À., Collins, M. O., Reig-viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J. S., Emes, R. D. & Grant, S. G. N., 2 Mar 2017, In : Nature Communications. 8, 14613

    Research output: Contribution to journalArticle

  21. Calcium-permeable AMPA receptors and silent synapses in cocaine-conditioned place preference

    Shukla, A., Beroun, A., Panopoulou, M., Neumann, P. A., Grant, S. G., Olive, M. F., Dong, Y. & Schlüter, O. M., 11 Jan 2017, In : EMBO Journal.

    Research output: Contribution to journalArticle

  22. Haploinsufficiency of EHMT1 improves pattern separation and increases hippocampal cell proliferation

    Benevento, M., Oomen, C. A., Horner, A. E., Amiri, H., Jacobs, T., Pauwels, C., Frega, M., Kleefstra, T., Kopanitsa, M. V., Grant, S., Bussey, T. J., Saksida, L. M., Van der Zee, C. E. E. M., van Bokhoven, H., Glennon, J. C. & Kasri, N. N., 10 Jan 2017, In : Scientific Reports.

    Research output: Contribution to journalArticle

  23. 2016
  24. Standardised experiments in mutant mice reveal behavioural similarity on 129S5 and C57BL/6J backgrounds

    van de Lagemaat, L. N., Stanford, L. E., Pettit, C., Strathdee, D. J., Strathdee, K. E., Elsegood, K. A., Fricker, D. G., Croning, M. D. R., Komiyama, N. H. & Grant, S. G. N., 25 Nov 2016, In : Genes Brain and Behavior.

    Research output: Contribution to journalArticle

  25. ATP from synaptic terminals and astrocytes regulates NMDA receptors and synaptic plasticity through PSD-95 multi-protein complex

    Lalo, U., Palygin, O., Verkhratsky, A., Grant, S. & Pankratov, Y., 19 Sep 2016, In : Scientific Reports. 6, 20 p., 33609

    Research output: Contribution to journalArticle

  26. Altered Thalamocortical Development in the SAP102 Knockout Model of Intellectual Disability

    Crocker-Buque, A., Currie, S. P., Luz, L. L., Grant, S. G., Duffy, K. R., Kind, P. C. & Daw, M. I., 27 Jul 2016, In : Human Molecular Genetics.

    Research output: Contribution to journalArticle

  27. Neurobeachin Regulates Glutamate- and GABA-Receptor Targeting to Synapses via Distinct Pathways

    Farzana, F., Zalm, R., Chen, N., Li, K. W., Grant, S. G. N., Smit, A. B., Toonen, R. F. & Verhage, M., 2 May 2016, In : Molecular Neurobiology. 53, 4, p. 2112-2123 12 p.

    Research output: Contribution to journalArticle

  28. NMDA receptors are selectively partitioned into complexes and supercomplexes during synapse maturation

    Frank, R. A. W., Komiyama, N. H., Ryan, T. J., Zhu, F., O'Dell, T. J. & Grant, S. G. N., 27 Apr 2016, In : Nature Communications. 7, p. 11264

    Research output: Contribution to journalArticle

  29. PSD95 nanoclusters are postsynaptic building blocks in hippocampus circuits

    Broadhead, M. J., Horrocks, M. H., Zhu, F., Muresan, L., Benavides-Piccione, R., DeFelipe, J., Fricker, D., Kopanitsa, M. V., Duncan, R. R., Klenerman, D., Komiyama, N. H., Lee, S. F. & Grant, S. G. N., 25 Apr 2016, In : Scientific Reports. 6, p. 24626

    Research output: Contribution to journalArticle

  30. Identification of vulnerable cell types in major brain disorders using single cell transcriptomes and expression weighted cell type enrichment

    Skene, N. G. & Grant, S. G. N., 27 Jan 2016, In : Frontiers in Neuroscience. 10, JAN, 16

    Research output: Contribution to journalArticle

  31. The molecular evolution of the vertebrate behavioural repertoire

    Grant, S. G. N., 5 Jan 2016, In : Philosophical Transactions of the Royal Society B: Biological Sciences. 371, 1685, 20150051

    Research output: Contribution to journalArticle

  32. Synaptopathy - From biology to therapy

    Grant, S. G. N., Bagni, C. & O'Dell, T. J., 1 Jan 2016, In : Neuropharmacology. 100, p. 1 1 p.

    Research output: Contribution to journalEditorial

  33. 2015
  34. Convergence of hippocampal pathophysiology in Syngap+/- and Fmr1-/y mice

    Barnes, S., Wijetunge, L., Jackson, A. D., Katsanevaki, D., Osterweil, E., Komiyama, N., Grant, S., Bear, M. F., Nägerl, U. V., Kind, P. & Wyllie, D., 11 Nov 2015, In : Journal of Neuroscience. 35, 45, p. 15073-15081

    Research output: Contribution to journalArticle

  35. Bridging the translational divide: identical cognitive touchscreen testing in mice and humans carrying mutations in a disease-relevant homologous gene

    Nithianantharajah, J., McKechanie, A. G., Stewart, T. J., Johnstone, M., Blackwood, D. H., St Clair, D., Grant, S. G. N., Bussey, T. J. & Saksida, L. M., 1 Oct 2015, In : Scientific Reports. 5, p. 14613

    Research output: Contribution to journalArticle

  36. Canalization of genetic and pharmacological perturbations in developing primary neuronal activity patterns

    Charlesworth, P., Morton, A., Eglen, S. J., Komiyama, N. H. & Grant, S. G. N., 26 Jul 2015, In : Neuropharmacology.

    Research output: Contribution to journalArticle

  37. NMDA receptor subunits and associated signaling molecules mediating antidepressant-related effects of NMDA-GluN2B antagonism

    Kiselycznyk, C., Jury, N. J., Halladay, L. R., Nakazawa, K., Mishina, M., Sprengel, R., Grant, S. G. N., Svenningsson, P. & Holmes, A., 1 Jul 2015, In : Behavioural Brain Research. 287, p. 89-95 7 p.

    Research output: Contribution to journalArticle

  38. Durable fear memories require PSD-95

    Fitzgerald, P. J., Pinard, C. R., Camp, M. C., Feyder, M., Sah, A., Bergstrom, H. C., Graybeal, C., Liu, Y., Schlüter, O. M., Grant, S. G., Singewald, N., Xu, W. & Holmes, A., Jul 2015, In : Molecular Psychiatry. 20, 7, p. 901-12 12 p.

    Research output: Contribution to journalArticle

  39. Tolerance to ethanol intoxication after chronic ethanol: role of GluN2A and PSD-95

    Daut, R. A., Busch, E. F., Ihne, J., Fisher, D., Mishina, M., Grant, S. G. N., Camp, M. & Holmes, A., Mar 2015, In : Addiction Biology. 20, 2, p. 259-262 4 p.

    Research output: Contribution to journalArticle

  40. Quantitative differences in developmental profiles of spontaneous activity in cortical and hippocampal cultures

    Charlesworth, P., Cotterill, E., Morton, A., Grant, S. G. N. & Eglen, S. J., 28 Jan 2015, In : Neural Development. 10, p. 1

    Research output: Contribution to journalArticle

  41. Novel MPDZ/MUPP1 transgenic and knockdown models confirm Mpdz's role in ethanol withdrawal and support its role in voluntary ethanol consumption

    Milner, L. C., Shirley, R. L., Kozell, L. B., Walter, N. A., Kruse, L. C., Komiyama, N. H., Grant, S. G. N. & Buck, K. J., Jan 2015, In : Addiction Biology. 20, 1, p. 143-147 5 p.

    Research output: Contribution to journalArticle

  42. 2014
  43. Human post-mortem synapse proteome integrity screening for proteomic studies of postsynaptic complexes

    Bayés, A., Collins, M. O., Galtrey, C. M., Simonnet, C., Roy, M., Croning, M., Gou, G., van de Lagemaat, L. N., Milward, D., Whittle, I. R., Smith, C., Choudhary, J. S. & Grant, S., 28 Nov 2014, In : Molecular brain research. 7, 1, p. 88

    Research output: Contribution to journalArticle

  44. A polygenic burden of rare disruptive mutations in schizophrenia

    Purcell, S. M., Moran, J. L., Fromer, M., Ruderfer, D., Solovieff, N., Roussos, P., O'Dushlaine, C., Chambert, K., Bergen, S. E., Kahler, A., Duncan, L., Stahl, E., Genovese, G., Fernandez, E., Collins, M. O., Komiyama, N. H., Choudhary, J. S., Magnusson, P. K. E., Banks, E., Shakir, K. & 12 othersGarimella, K., Fennell, T., DePristo, M., Grant, S. G. N., Haggarty, S. J., Gabriel, S., Scolnick, E. M., Lander, E. S., Hultman, C. M., Sullivan, P. F., McCarroll, S. A. & Sklar, P., 13 Feb 2014, In : Nature. 506, 7487, p. 185-+ 17 p.

    Research output: Contribution to journalArticle

  45. De novo mutations in schizophrenia implicate synaptic networks

    Fromer, M., Pocklington, A. J., Kavanagh, D. H., Williams, H. J., Dwyer, S., Gormley, P., Georgieva, L., Rees, E., Palta, P., Ruderfer, D. M., Carrera, N., Humphreys, I., Johnson, J. S., Roussos, P., Barker, D. D., Banks, E., Milanova, V., Grant, S. G., Hannon, E., Rose, S. A. & 12 othersChambert, K., Mahajan, M., Scolnick, E. M., Moran, J. L., Kirov, G., Palotie, A., McCarroll, S. A., Holmans, P., Sklar, P., Owen, M. J., Purcell, S. M. & O'Donovan, M. C., 13 Feb 2014, In : Nature. 506, 7487, p. 179-+ 16 p.

    Research output: Contribution to journalArticle

  46. Human cognitive ability is influenced by genetic variation in components of postsynaptic signalling complexes assembled by NMDA receptors and MAGUK proteins

    Hill, W. D., Davies, G., Van De Lagemaat, L., Christoforou, A., Marioni, R. E., Fernandes, C. P. D., Liewald, D. C., Croning, M. D. R., Payton, A., Craig, L. C. A., Whalley, L. J., Horan, M., Ollier, W., Hansell, N. K., Wright, M. J., Martin, N. G., Montgomery, G. W., Steen, V. M., Le Hellard, S., Espeseth, T. & 7 othersLundervold, A. J., Reinvang, I., Starr, J. M., Pendleton, N., Grant, S. G. N., Bates, T. C. & Deary, I. J., 7 Jan 2014, In : Translational Psychiatry. 4, 1, 8 p., 341

    Research output: Contribution to journalArticle

  47. 2013
  48. Human cognitive ability is influenced by genetic variation in components of postsynaptic signaling complexes assembled by MAGUK proteins

    Hill, W. D., Davies, G., Van de Lagemaat, L., Christoforou, A., Fernandes, C., Liewald, D., Croning, M., Payton, A., Craig, L., Whalley, L., Horan, M., Ollier, W., Hansell, N., Wright, M., Martin, N. G., Montgomery, G., Steen, V., Le Hellard, S., Espeseth, T., Lundervold, A. & 6 othersReinvang, I., Starr, J., Pendleton, N., Grant, S., Bates, T. & Deary, I., Nov 2013, In : Behavior Genetics. 43, 6, p. 521-522 2 p.

    Research output: Contribution to journalMeeting abstract

  49. SnapShot: Organizational principles of the postsynaptic proteome

    Grant, S. G. N., 16 Oct 2013, In : Neuron. 80, 2, p. 534.e1

    Research output: Contribution to journalArticle

  50. Cognitive components in mice and humans: Combining genetics and touchscreens for medical translation

    Nithianantharajah, J. & Grant, S. G. N., Oct 2013, In : Neurobiology of Learning and Memory. 105, p. 13-19 7 p.

    Research output: Contribution to journalArticle

  51. CYFIP1 Coordinates mRNA Translation and Cytoskeleton Remodeling to Ensure Proper Dendritic Spine Formation

    De Rubeis, S., Pasciuto, E., Li, K. W., Fernández, E., Di Marino, D., Buzzi, A., Ostroff, L. E., Klann, E., Zwartkruis, F. J. T., Komiyama, N. H., Grant, S. G. N., Poujol, C., Choquet, D., Achsel, T., Posthuma, D., Smit, A. B. & Bagni, C., 18 Sep 2013, In : Neuron. 79, 6, p. 1169-82 14 p.

    Research output: Contribution to journalArticle

  52. Probing the Modulation of Acute Ethanol Intoxication by Pharmacological Manipulation of the NMDAR Glycine Co-Agonist Site

    DeBrouse, L., Hurd, B., Kiselycznyk, C., Plitt, A., Todaro, A., Mishina, M., Grant, S. G. N., Camp, M., Gunduz-Cinar, O. & Holmes, A., Feb 2013, In : Alcoholism-Clinical and experimental research. 37, 2, p. 223-233 11 p.

    Research output: Contribution to journalArticle

  53. SynSysNet: integration of experimental data on synaptic protein-protein interactions with drug-target relations

    von Eichborn, J., Dunkel, M., Gohlke, B. O., Preissner, S. C., Hoffmann, M. F., Bauer, J. M. J., Armstrong, D., Schaefer, M. H., Andrade-Navarro, M. A., Le Novere, N., Croning, M. D. R., Grant, S. G. N., van Nierop, P., Smit, A. B. & Preissner, R., Jan 2013, In : Nucleic Acids Research. 41, D1, p. D834-D840 7 p.

    Research output: Contribution to journalArticle

  54. Synaptic scaffold evolution generated components of vertebrate cognitive complexity

    Nithianantharajah, J., Komiyama, N., McKechanie, A., Johnstone, M., Blackwood, D. H., Clair, D. S., Emes, R. D., van de Lagemaat, L. N., Saksida, L. M., Bussey, T. J. & Grant, S. G. N., Jan 2013, In : Nature Neuroscience. 16, 1, p. 16-24 9 p.

    Research output: Contribution to journalArticle

  55. Evolution of GluN2A/B cytoplasmic domains diversified vertebrate synaptic plasticity and behavior

    Ryan, T. J., Kopanitsa, M. V., Indersmitten, T., Nithianantharajah, J., Afinowi, N. O., Pettit, C., Stanford, L. E., Sprengel, R., Saksida, L. M., Bussey, T. J., O'Dell, T. J., Grant, S. G. N. & Komiyama, N., 2013, In : Nature Neuroscience. 16, 1, p. 25-32 8 p.

    Research output: Contribution to journalArticle

  56. 2012
  57. The association between cognitive abilities and the postsynaptic proteome of central excitatory synapses

    Hill, W. D., Davies, G., Croning, M., Payton, A., Craig, L., Horan, M., Ollier, WI., Starr, J., Pendleton, N., Grant, S., Bates, T. & Deary, I., Nov 2012, In : Behavior Genetics. 42, 6, p. 938-938 1 p.

    Research output: Contribution to journalMeeting abstract

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