Edinburgh Research Explorer

Prof Seth Grant

Personal Chair of Molecular Neuroscience

  1. Chapter (peer-reviewed) › Research › Not peer-reviewed
  2. The Organization and integrative function of the post-synaptic proteome

    Grant, S., Husi, H., Choudhary, J., Cumiskey, M., Blackstock, W. & Armstrong, D., 2004, Excitatory-Inhibitory Balance: Synapses, Circuits, Systems. KLUWER ACADEMIC/PLENUM PUBL, p. 13-44 32 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

  3. Poster › Research › Peer-reviewed
  4. Genetic Dissection Of Cognition In Humans And Mice Carrying Mutations: Evidence That Vertebrate Genomic Evolution Produced Susceptibility To Mental Illnesses

    Nithianantharajah, J., McKechanie, A., Komiyama, N., Emes, R. D., Saksida, L. M., Bussey, T. J. & Grant, S., 18 Jul 2012, p. 641.

    Research output: Contribution to conferencePoster

  5. Article › Research › Peer-reviewed
  6. In Vivo Composition of NMDA Receptor Signaling Complexes Differs between Membrane Subdomains and Is Modulated by PSD-95 And PSD-93

    Delint-Ramirez, I., Fernandez, E., Bayes, A., Kicsi, E., Komiyama, N. & Grant, S. G. N., 16 Jun 2010, In : The Journal of Neuroscience. 30, 24, p. 8162-8170 9 p.

    Research output: Contribution to journalArticle

  7. A genomic lifespan program that reorganises the young adult brain is targeted in schizophrenia

    Skene, N. G., Roy, M. & Grant, S. G., 12 Sep 2017, In : eLIFE. 6

    Research output: Contribution to journalArticle

  8. A polygenic burden of rare disruptive mutations in schizophrenia

    Purcell, S. M., Moran, J. L., Fromer, M., Ruderfer, D., Solovieff, N., Roussos, P., O'Dushlaine, C., Chambert, K., Bergen, S. E., Kahler, A., Duncan, L., Stahl, E., Genovese, G., Fernandez, E., Collins, M. O., Komiyama, N. H., Choudhary, J. S., Magnusson, P. K. E., Banks, E., Shakir, K. & 12 othersGarimella, K., Fennell, T., DePristo, M., Grant, S. G. N., Haggarty, S. J., Gabriel, S., Scolnick, E. M., Lander, E. S., Hultman, C. M., Sullivan, P. F., McCarroll, S. A. & Sklar, P., 13 Feb 2014, In : Nature. 506, 7487, p. 185-+ 17 p.

    Research output: Contribution to journalArticle

  9. ATP from synaptic terminals and astrocytes regulates NMDA receptors and synaptic plasticity through PSD-95 multi-protein complex

    Lalo, U., Palygin, O., Verkhratsky, A., Grant, S. & Pankratov, Y., 19 Sep 2016, In : Scientific Reports. 6, 20 p., 33609.

    Research output: Contribution to journalArticle

  10. Altered Thalamocortical Development in the SAP102 Knockout Model of Intellectual Disability

    Crocker-Buque, A., Currie, S. P., Luz, L. L., Grant, S. G., Duffy, K. R., Kind, P. C. & Daw, M. I., 27 Jul 2016, In : Human Molecular Genetics.

    Research output: Contribution to journalArticle

  11. An anatomically comprehensive atlas of the adult human brain transcriptome

    Hawrylycz, M. J., Lein, E. S., Guillozet-Bongaarts, A. L., Shen, E. H., Ng, L., Miller, J. A., Van De Lagemaat, L., Smith, K. A., Ebbert, A., Riley, Z. L., Abajian, C., Beckmann, C. F., Bernard, A., Bertagnolli, D., Boe, A. F., Cartagena, P. M., Chakravarty, M. M., Chapin, M., Chong, J., Dalley, R. A. & 47 othersDaly, B. D., Dang, C., Datta, S., Dee, N., Dolbeare, T. A., Faber, V., Feng, D., Fowler, D. R., Goldy, J., Gregor, B. W., Haradon, Z., Haynor, D. R., Hohmann, J. G., Horvath, S., Howard, R. E., Jeromin, A., Jochim, J. M., Kinnunen, M., Lau, C., Lazarz, E. T., Lee, C., Lemon, T. A., Li, L., Li, Y., Morris, J. A., Overly, C. C., Parker, P. D., Parry, S. E., Reding, M., Royall, J. J., Schulkin, J., Sequeira, P. A., Slaughterbeck, C. R., Smith, S. C., Sodt, A. J., Sunkin, S. M., Swanson, B. E., Vawter, M. P., Williams, D., Wohnoutka, P., Zielke, H. R., Geschwind, D. H., Hof, P. R., Smith, S. M., Koch, C., Grant, S. G. N. & Jones, A. R., 2012, In : Nature. 489, 7416, p. 391-399 9 p.

    Research output: Contribution to journalArticle

  12. Arc requires PSD95 for assembly into postsynaptic complexes involved with brain disease and intelligence

    Fernandez, E., Collins, M. O., Frank, R. A. W., Zhu, F., Kopanitsa, M. V., Nithianantharajah, J., Lempriere, S., Fricker, D. G., Elsegood, K. A., McLaughlin, C., Croning, M. D. R., McLean, C., Armstrong, J. D., Hill, W. D., Deary, I., Cencelli, G., Bagni, C., Fromer, M., Purcell, S. M., Pocklington, A. J. & 3 othersChoudhary, J. S., Komiyama, N. & Grant, S., 17 Oct 2017, In : Cell Reports. 21, 3, p. 679-691

    Research output: Contribution to journalArticle

  13. Architecture of the Mouse Brain Synaptome

    Zhu, F., Cizeron, M., Qiu, Z., Benavides-piccione, R., Kopanitsa, M. V., Skene, N. G., Koniaris, B., Defelipe, J., Fransén, E., Komiyama, N. H. & Grant, S. G. N., 2 Aug 2018, In : Neuron.

    Research output: Contribution to journalArticle

  14. Association of Mouse Dlg4 (PSD-95) Gene Deletion and Human DLG4 Gene Variation With Phenotypes Relevant to Autism Spectrum Disorders and Williams' Syndrome

    Feyder, M., Karlsson, R-M., Mathur, P., Lyman, M., Bock, R., Momenan, R., Munasinghe, J., Scattoni, M. L., Ihne, J., Camp, M., Graybeal, C., Strathdee, D., Begg, A., Alvarez, V. A., Kirsch, P., Rietschel, M., Cichon, S., Walter, H., Meyer-Lindenberg, A., Grant, S. G. N. & 1 othersHolmes, A., Dec 2010, In : American Journal of Psychiatry. 167, 12, p. 1508-1517 10 p.

    Research output: Contribution to journalArticle

  15. Automated design of genomic Southern blot probes

    Croning, M. D. R., Fricker, D. G., Komiyama, N. H. & Grant, S. G. N., 2010, In : BMC Genomics. 11, p. 74

    Research output: Contribution to journalArticle

  16. Beta-adrenergic receptor activation rescues theta frequency stimulation-induced LTP deficits in mice expressing C-terminally truncated NMDA receptor GluN2A subunits

    Moody, T. D., Watabe, A. M., Indersmitten, T., Komiyama, N. H., Grant, S. G. N. & O'Dell, T. J., Feb 2011, In : Learning and Memory. 18, 2, p. 118-27 10 p.

    Research output: Contribution to journalArticle

  17. Bridging the translational divide: identical cognitive touchscreen testing in mice and humans carrying mutations in a disease-relevant homologous gene

    Nithianantharajah, J., McKechanie, A. G., Stewart, T. J., Johnstone, M., Blackwood, D. H., St Clair, D., Grant, S. G. N., Bussey, T. J. & Saksida, L. M., 1 Oct 2015, In : Scientific Reports. 5, p. 14613

    Research output: Contribution to journalArticle

  18. CYFIP1 Coordinates mRNA Translation and Cytoskeleton Remodeling to Ensure Proper Dendritic Spine Formation

    De Rubeis, S., Pasciuto, E., Li, K. W., Fernández, E., Di Marino, D., Buzzi, A., Ostroff, L. E., Klann, E., Zwartkruis, F. J. T., Komiyama, N. H., Grant, S. G. N., Poujol, C., Choquet, D., Achsel, T., Posthuma, D., Smit, A. B. & Bagni, C., 18 Sep 2013, In : Neuron. 79, 6, p. 1169-82 14 p.

    Research output: Contribution to journalArticle

  19. Calcium-permeable AMPA receptors and silent synapses in cocaine-conditioned place preference

    Shukla, A., Beroun, A., Panopoulou, M., Neumann, P. A., Grant, S. G., Olive, M. F., Dong, Y. & Schlüter, O. M., 11 Jan 2017, In : EMBO Journal.

    Research output: Contribution to journalArticle

  20. Canalization of genetic and pharmacological perturbations in developing primary neuronal activity patterns

    Charlesworth, P., Morton, A., Eglen, S. J., Komiyama, N. H. & Grant, S. G. N., 26 Jul 2015, In : Neuropharmacology.

    Research output: Contribution to journalArticle

  21. Cell‐type specific visualization and biochemical isolation of endogenous synaptic proteins in mice

    Zhu, F., Collins, M. O., Harmse, J., Choudhary, J. S., Grant, S. G. N. & Komiyama, N. H., 16 Oct 2019, In : European Journal of Neuroscience.

    Research output: Contribution to journalArticle

  22. Characterization of the proteome, diseases and evolution of the human postsynaptic density

    Bayes, A., Van De Lagemaat, L., Collins, M. O., Croning, M. D. R., Whittle, I. R., Choudhary, J. S. & Grant, S. G. N., Jan 2011, In : Nature Neuroscience. 14, 1, p. 19-21 3 p.

    Research output: Contribution to journalArticle

  23. Chronic treatment with a MEK inhibitor reverses enhanced excitatory field potentials in Syngap1 mice

    Kopanitsa, M. V., Gou, G., Afinowi, N. O., Bayés, À., Grant, S. G. N. & Komiyama, N. H., Aug 2018, In : Pharmacological reports. 70, 4, p. 777-783 7 p.

    Research output: Contribution to journalArticle

  24. Cognitive components in mice and humans: Combining genetics and touchscreens for medical translation

    Nithianantharajah, J. & Grant, S. G. N., Oct 2013, In : Neurobiology of Learning and Memory. 105, p. 13-19 7 p.

    Research output: Contribution to journalArticle

  25. Comparative Study of Human and Mouse Postsynaptic Proteomes Finds High Compositional Conservation and Abundance Differences for Key Synaptic Proteins

    Bayes, A., Collins, M. O., Croning, M. D. R., Van De Lagemaat, L., Choudhary, J. S. & Grant, S. G. N., 5 Oct 2012, In : PLoS ONE. 7, 10, p. - 13 p., e46683.

    Research output: Contribution to journalArticle

  26. Comprehensive behavioral analysis of heterozygous Syngap1knockout mice

    Nakajima, R., Takao, K., Hattori, S., Shoji, H., Komiyama, N. H., Grant, S. G. N. & Miyakawa, T., 19 Jul 2019, In : Neuropsychopharmacology Reports.

    Research output: Contribution to journalArticle

  27. Computational geometry analysis of dendritic spines by structured illumination microscopy

    Kashiwagi, Y., Higashi, T., Obashi, K., Sato, Y., Komiyama, N. H., Grant, S. G. N. & Okabe, S., 20 Mar 2019, In : Nature Communications. 10, 1

    Research output: Contribution to journalArticle

  28. Convergence of hippocampal pathophysiology in Syngap+/- and Fmr1-/y mice

    Barnes, S., Wijetunge, L., Jackson, A. D., Katsanevaki, D., Osterweil, E., Komiyama, N., Grant, S., Bear, M. F., Nägerl, U. V., Kind, P. & Wyllie, D., 11 Nov 2015, In : Journal of Neuroscience. 35, 45, p. 15073-15081

    Research output: Contribution to journalArticle

  29. De novo CNV analysis implicates specific abnormalities of postsynaptic signalling complexes in the pathogenesis of schizophrenia

    Kirov, G., Pocklington, A. J., Holmans, P., Ivanov, D., Ikeda, M., Ruderfer, D., Moran, J., Chambert, K., Toncheva, D., Georgieva, L., Grozeva, D., Fjodorova, M., Wollerton, R., Rees, E., Nikolov, I., Van De Lagemaat, L., Bayés, A., Fernandez, E., Olason, P. I., Böttcher, Y. & 10 othersKomiyama, N. H., Collins, M. O., Choudhary, J., Stefansson, K., Stefansson, H., Grant, S. G. N., Purcell, S., Sklar, P., O'Donovan, M. C. & Owen, M. J., Feb 2012, In : Molecular Psychiatry. 17, 2, p. 142-153 12 p.

    Research output: Contribution to journalArticle

  30. De novo mutations in schizophrenia implicate synaptic networks

    Fromer, M., Pocklington, A. J., Kavanagh, D. H., Williams, H. J., Dwyer, S., Gormley, P., Georgieva, L., Rees, E., Palta, P., Ruderfer, D. M., Carrera, N., Humphreys, I., Johnson, J. S., Roussos, P., Barker, D. D., Banks, E., Milanova, V., Grant, S. G., Hannon, E., Rose, S. A. & 12 othersChambert, K., Mahajan, M., Scolnick, E. M., Moran, J. L., Kirov, G., Palotie, A., McCarroll, S. A., Holmans, P., Sklar, P., Owen, M. J., Purcell, S. M. & O'Donovan, M. C., 13 Feb 2014, In : Nature. 506, 7487, p. 179-+ 16 p.

    Research output: Contribution to journalArticle

  31. Dlg3 Trafficking and Apical Tight Junction Formation Is Regulated by Nedd4 and Nedd4-2 E3 Ubiquitin Ligases

    Van Campenhout, C. A., Eitelhuber, A., Gloeckner, C. J., Giallonardo, P., Gegg, M., Oller, H., Grant, S. G. N., Krappmann, D., Ueffing, M. & Lickert, H., 13 Sep 2011, In : Developmental Cell. 21, 3, p. 479-491 13 p.

    Research output: Contribution to journalArticle

  32. Dlgap1 knockout mice exhibit alterations of the postsynaptic density and selective reductions in sociability

    Coba, M. P., Ramaker, M. J., Ho, E. V., Thompson, S. L., Komiyama, N. H., Grant, S. G. N., Knowles, J. A. & Dulawa, S. C., 2 Feb 2018, In : Scientific Reports. 8, 1

    Research output: Contribution to journalArticle

  33. Durable fear memories require PSD-95

    Fitzgerald, P. J., Pinard, C. R., Camp, M. C., Feyder, M., Sah, A., Bergstrom, H. C., Graybeal, C., Liu, Y., Schlüter, O. M., Grant, S. G., Singewald, N., Xu, W. & Holmes, A., Jul 2015, In : Molecular Psychiatry. 20, 7, p. 901-12 12 p.

    Research output: Contribution to journalArticle

  34. Efficient linkage of 10 loci in the proximal region of the mouse X chromosome

    Mullins, L. J., Stephenson, D. A., Grant, S. G. & Chapman, V. M., May 1990, In : Genomics. 7, 1, p. 19-30 12 p.

    Research output: Contribution to journalArticle

  35. Enhanced cognition and dysregulated hippocampal synaptic physiology in mice with a heterozygous deletion of PSD-95

    Horner, A. E., McLaughlin, C. L., Afinowi, N. O., Bussey, T. J., Saksida, L. M., Komiyama, N. H., Grant, S. G. N. & Kopanitsa, M. V., 13 Dec 2017, In : European Journal of Neuroscience.

    Research output: Contribution to journalArticle

  36. Evolution of GluN2A/B cytoplasmic domains diversified vertebrate synaptic plasticity and behavior

    Ryan, T. J., Kopanitsa, M. V., Indersmitten, T., Nithianantharajah, J., Afinowi, N. O., Pettit, C., Stanford, L. E., Sprengel, R., Saksida, L. M., Bussey, T. J., O'Dell, T. J., Grant, S. G. N. & Komiyama, N., 2013, In : Nature Neuroscience. 16, 1, p. 25-32 8 p.

    Research output: Contribution to journalArticle

  37. Evolution of NMDA receptor cytoplasmic interaction domains: implications for organisation of synaptic signalling complexes

    Ryan, T. J., Emes, R. D., Grant, S. G. & Komiyama, N. H., 2008, In : BMC Neuroscience. 9, p. 6

    Research output: Contribution to journalArticle

  38. Evolution of complexity in the zebrafish synapse proteome

    Bayés, À., Collins, M. O., Reig-viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J. S., Emes, R. D. & Grant, S. G. N., 2 Mar 2017, In : Nature Communications. 8, 14613.

    Research output: Contribution to journalArticle

  39. Evolutionary expansion and anatomical specialization of synapse proteome complexity

    Emes, R. D., Pocklington, A. J., Anderson, C. N. G., Bayes, A., Collins, M. O., Vickers, C. A., Croning, M. D. R., Malik, B. R., Choudhary, J. S., Armstrong, D. & Grant, S., Jul 2008, In : Nature Neuroscience. 11, 7, p. 799-806 8 p.

    Research output: Contribution to journalArticle

  40. FAK is required for axonal sorting by Schwann cells

    Grove, M., Komiyama, N. H., Nave, K-A., Grant, S. G., Sherman, D. L. & Brophy, P. J., 2007, In : The Journal of Cell Biology. 176, 3, p. 277-82 6 p.

    Research output: Contribution to journalArticle

  41. G2Cdb: the Genes to Cognition database

    Croning, M. D. R., Marshall, M. C., McLaren, P., Armstrong, J. D. & Grant, S. G. N., Jan 2009, In : Nucleic Acids Research. 37, p. D846-D851 6 p.

    Research output: Contribution to journalArticle

  42. Genome variation and complexity in the autism spectrum

    van de Lagemaat, L. N. & Grant, S. G. N., 15 Jul 2010, In : Neuron. 67, 1, p. 8-10 3 p.

    Research output: Contribution to journalArticle

  43. Haploinsufficiency of EHMT1 improves pattern separation and increases hippocampal cell proliferation

    Benevento, M., Oomen, C. A., Horner, A. E., Amiri, H., Jacobs, T., Pauwels, C., Frega, M., Kleefstra, T., Kopanitsa, M. V., Grant, S., Bussey, T. J., Saksida, L. M., Van der Zee, C. E. E. M., van Bokhoven, H., Glennon, J. C. & Kasri, N. N., 10 Jan 2017, In : Scientific Reports.

    Research output: Contribution to journalArticle

  44. Hierarchical organisation and genetically separable subfamilies of PSD95 postsynaptic supercomplexes

    Frank, R. A. W., Zhu, F., Komiyama, N. H. & Grant, S. G. N., 28 Apr 2017, In : Journal of Neurochemistry.

    Research output: Contribution to journalArticle

  45. Human cognitive ability is influenced by genetic variation in components of postsynaptic signalling complexes assembled by NMDA receptors and MAGUK proteins

    Hill, W. D., Davies, G., Van De Lagemaat, L., Christoforou, A., Marioni, R. E., Fernandes, C. P. D., Liewald, D. C., Croning, M. D. R., Payton, A., Craig, L. C. A., Whalley, L. J., Horan, M., Ollier, W., Hansell, N. K., Wright, M. J., Martin, N. G., Montgomery, G. W., Steen, V. M., Le Hellard, S., Espeseth, T. & 7 othersLundervold, A. J., Reinvang, I., Starr, J. M., Pendleton, N., Grant, S. G. N., Bates, T. C. & Deary, I. J., 7 Jan 2014, In : Translational Psychiatry. 4, 1, 8 p., 341.

    Research output: Contribution to journalArticle

  46. Human post-mortem synapse proteome integrity screening for proteomic studies of postsynaptic complexes

    Bayés, A., Collins, M. O., Galtrey, C. M., Simonnet, C., Roy, M., Croning, M., Gou, G., van de Lagemaat, L. N., Milward, D., Whittle, I. R., Smith, C., Choudhary, J. S. & Grant, S., 28 Nov 2014, In : Molecular brain research. 7, 1, p. 88

    Research output: Contribution to journalArticle

  47. Identification of vulnerable cell types in major brain disorders using single cell transcriptomes and expression weighted cell type enrichment

    Skene, N. G. & Grant, S. G. N., 27 Jan 2016, In : Frontiers in Neuroscience. 10, JAN, 16.

    Research output: Contribution to journalArticle

  48. In vivo STED microscopy visualizes morphological changes of large PSD95 assemblies over several hours in the mouse visual cortex

    Wegner, W., Mott, A. C., Grant, S., Steffens, H. & Willig, K. I., 9 Jan 2018, In : Scientific Reports.

    Research output: Contribution to journalArticle

  49. Integrin-mediated axoglial interactions initiate myelination in the central nervous system

    Câmara, J., Wang, Z., Nunes-Fonseca, C., Friedman, H. C., Grove, M., Sherman, D. L., Komiyama, N. H., Grant, S. G., Brophy, P. J., Peterson, A. & ffrench-Constant, C., May 2009, In : The Journal of Cell Biology. 185, 4, p. 699-712 14 p.

    Research output: Contribution to journalArticle

  50. Multilocus molecular mapping of the mouse X chromosome

    Mullins, L. J., Grant, S. G., Stephenson, D. A. & Chapman, V. M., Oct 1988, In : Genomics. 3, 3, p. 187-94 8 p.

    Research output: Contribution to journalArticle

  51. NMDA receptor modulation of glutamate release in activated neutrophils

    Del Arroyo, A. G., Hadjihambi, A., Sanchez, J., Turovsky, E., Kasymov, V., Cain, D., Nightingale, T. D., Lambden, S., Grant, S. G. N., Gourine, A. V. & Ackland, G. L., 8 Aug 2019, In : EBioMedicine.

    Research output: Contribution to journalArticle

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