Edinburgh Research Explorer

Thomas Little

Personal Chair in Evolutionary Biology

  1. 2020
  2. DNA methylation differs extensively between strains of the same geographical origin and changes with age in Daphnia magna

    Hearn, J., Plenderleith, F. & Little, T. J., 7 Dec 2020, (Accepted/In press) In: Epigenetics & Chromatin.

    Research output: Contribution to journalArticlepeer-review

  3. Pathogen dynamics across the diversity of ageing

    Clark, J., McNally, L. & Little, T. J., 14 Sep 2020, (Accepted/In press) In: The American Naturalist.

    Research output: Contribution to journalArticlepeer-review

  4. Daphnia magna modifies its gene expression extensively in response to caloric restriction revealing a novel effect on haemoglobin isoform preference

    Hearn, J., Clark, J., Wilson, P. J. & Little, T. J., 20 Jul 2020, In: Molecular Ecology. p. 1-16

    Research output: Contribution to journalArticlepeer-review

  5. 2019
  6. Genome-wide methylation is modified by caloric restriction in Daphnia magna

    Hearn, J., Pearson, M., Blaxter, M., Wilson, P. J. & Little, T. J., 8 Mar 2019, In: BMC Genomics. 20, 1, p. 197 11 p.

    Research output: Contribution to journalArticlepeer-review

  7. 2018
  8. Mitogenome phylogeographic analysis of a planktonic crustacean

    Fields, P. D., Obbard, D. J., McTaggart, S. J., Galimov, Y., Little, T. J. & Ebert, D., 1 Dec 2018, In: Molecular phylogenetics and evolution. 129, p. 138-148 11 p.

    Research output: Contribution to journalArticlepeer-review

  9. Daphnia magna microRNAs respond to nutritional stress and ageing but are not transgenerational

    Hearn, J., Chow, F. W. N., Barton, H., Tung, M., Wilson, P. J., Blaxter, M., Buck, A. & Little, T. J., 7 Mar 2018, In: Molecular Ecology. 11 p.

    Research output: Contribution to journalArticlepeer-review

  10. Testing hypotheses for maternal effects in Daphnia magna

    Coakley, C., Nestoros, E. & Little, T., 6 Feb 2018, In: Journal of Evolutionary Biology. 31, 2, p. 211-216 6 p.

    Research output: Contribution to journalArticlepeer-review

  11. 2017
  12. Disease spread in age structured populations with maternal age effects

    Clark, J., Garbutt, J., McNally, L. & Little, T., 23 Mar 2017, In: Ecology Letters. 20, 4, p. 445–451 7 p.

    Research output: Contribution to journalArticlepeer-review

  13. Bigger is better: changes in body size explain a maternal effect of food on offspring disease resistance

    Garbutt, J. & Little, T., Mar 2017, In: Ecology and Evolution.

    Research output: Contribution to journalArticlepeer-review

  14. 2016
  15. Caging and uncaging genetics

    Little, T. J. & Colegrave, N., 26 Jul 2016, In: PLoS Biology. 14, 7

    Research output: Contribution to journalArticlepeer-review

  16. 2015
  17. Maternal effects on offspring consumption can stabilise fluctuating predator-prey systems

    Garbutt, J., Little, T. & Hoyle, A., 2 Dec 2015, In: Proceedings of the Royal Society B-Biological Sciences. 282, 1820, 20152173.

    Research output: Contribution to journalArticlepeer-review

  18. Transcriptome profiling during a natural host-parasite interaction

    McTaggart, S. J., Cézard, T., Garbutt, J., Wilson, P. J. & Little, T. J., 28 Aug 2015, In: BMC Genomics. 16, 643.

    Research output: Contribution to journalArticlepeer-review

  19. 2014
  20. Effects of juvenile host density and food availability on adult immune response, parasite resistance and virulence in a daphnia-parasite system

    Schoebel, C. N., Auld, S. K. J. R., Spaak, P. & Little, T., 15 Apr 2014, In: PLoS ONE. 9, 4, e94569.

    Research output: Contribution to journalArticlepeer-review

  21. Elevated maternal temperature enhances offspring disease resistance in Daphnia magna

    Garbutt, J., Scholefield, J., Vale, P. & Little, T., Apr 2014, In: Functional Ecology. 28, 2, p. 424-431 8 p.

    Research output: Contribution to journalArticlepeer-review

  22. Rapid change in parasite infection traits over the course of an epidemic in a wild host-parasite population

    Auld, S. K. J. R., Wilson, P. J. & Little, T., 1 Feb 2014, In: Oikos. 123, 2, p. 232-238 7 p.

    Research output: Contribution to journalArticlepeer-review

  23. Maternal food quantity affects offspring feeding rate in Daphnia magna

    Garbutt, J. & Little, T., 1 Jan 2014, In: Biology letters. 10, 7

    Research output: Contribution to journalArticlepeer-review

  24. 2013
  25. Host nutrition alters the variance in parasite transmission potential

    Little, T., Vale, P. & Choicy, M., Apr 2013, In: Biology letters. 9, 2, 20121145.

    Research output: Contribution to journalArticlepeer-review

  26. 2012
  27. Fecundity compensation and tolerance to a sterilizing pathogen in Daphnia

    Vale, P. & Little, T. J., Sep 2012, In: Journal of Evolutionary Biology. 25, 9, p. 1888-1896 9 p.

    Research output: Contribution to journalArticlepeer-review

  28. Immune genes undergo more adaptive evolution than non-immune system genes in Daphnia pulex

    McTaggart, S. J., Obbard, D. J., Conlon, C. & Little, T., 11 May 2012, In: BMC Evolutionary Biology. 12, 11 p., 63.

    Research output: Contribution to journalArticlepeer-review

  29. Elevated haemocyte number is associated with infection and low fitness potential in wild Daphnia magna

    Auld, S. K. J. R., Graham, A. L., Wilson, P. J. & Little, T., Apr 2012, In: Functional Ecology. 26, 2, p. 434-440 7 p.

    Research output: Contribution to journalArticlepeer-review

  30. Harnessing evolutionary biology to combat infectious disease

    Little, T., Allen, J. E., Babayan, S. A., Matthews, K. R. & Colegrave, N., Feb 2012, In: Nature Medicine. 18, 2, p. 217-220 4 p.

    Research output: Contribution to journalArticlepeer-review

  31. 2011
  32. Genetic variation for maternal effects on parasite susceptibility

    Stjernman, M. & Little, T. J., 30 Nov 2011, In: Journal of Evolutionary Biology. 24, 11, p. 2357-2363 7 p.

    Research output: Contribution to journalArticlepeer-review

  33. Alternative splicing of the Anopheles gambiae Dscam gene in diverse Plasmodium falciparum infections

    Smith, P. H., Mwangi, J. M., Afrane, Y. A., Yan, G., Obbard, D. J., Ranford-Cartwright, L. C. & Little, T. J., 8 Jun 2011, In: Malaria Journal. 10, 156, p. - 7 p.

    Research output: Contribution to journalArticlepeer-review

  34. Epidemiological, Evolutionary, and Coevolutionary Implications of Context-Dependent Parasitism

    Vale, P., Wilson, A. J., Best, A., Boots, M. & Little, T. J., Apr 2011, In: The American Naturalist. 177, 4, p. 510-521 12 p.

    Research output: Contribution to journalArticlepeer-review

  35. Fitness consequences of immune responses: strengthening the empirical framework for ecoimmunology

    Graham, A. L., Shuker, D. M., Pollitt, L. C., Auld, S. K. J. R., Wilson, A. J. & Little, T. J., 28 Feb 2011, In: Functional Ecology. 25, 1, p. 517 13 p.

    Research output: Contribution to journalArticlepeer-review

  36. Recent and Recurrent Selective Sweeps of the Antiviral RNAi Gene Argonaute-2 in Three Species of Drosophila

    Obbard, D. J., Jiggins, F. M., Bradshaw, N. J. & Little, T. J., Feb 2011, In: Molecular Biology and Evolution. 28, 2, p. 1043-1056 14 p.

    Research output: Contribution to journalArticlepeer-review

  37. Identifying energy constraints to parasite resistance

    Allen, D. E. & Little, T. J., Jan 2011, In: Journal of Evolutionary Biology. 24, 1, p. 224-229 6 p.

    Research output: Contribution to journalArticlepeer-review

  38. Candidate innate immune system gene expression in the ecological model Daphnia

    Decaestecker, E., Labbé, P., Ellegaard, K., Allen, J. E. & Little, T. J., 2011, In: Developmental and Comparative Immunology. 35, 10, p. 1068-77 10 p.

    Research output: Contribution to journalArticlepeer-review

  39. 2010
  40. Successfully resisting a pathogen is rarely costly in Daphnia magna

    Labbe, P., Vale, P. & Little, T. J., 17 Nov 2010, In: BMC Evolutionary Biology. 10, p. - 12 p., 355.

    Research output: Contribution to journalArticlepeer-review

  41. Genetic variation in the cellular response of Daphnia magna (Crustacea: Cladocera) to its bacterial parasite

    Auld, S. K. J. R., Scholefield, J. A. & Little, T. J., 7 Nov 2010, In: Proceedings of the Royal Society B-Biological Sciences. 277, 1698, p. 3291-3297 7 p.

    Research output: Contribution to journalArticlepeer-review

  42. The Coevolution of Virulence: Tolerance in Perspective

    Little, T. J., Shuker, D. M., Colegrave, N., Day, T. & Graham, A. L., Sep 2010, In: Plos Pathogens. 6, 9, p. - 5 p., e1001006.

    Research output: Contribution to journalLiterature reviewpeer-review

  43. Dissecting the effect of a heterogeneous environment on the interaction between host and parasite fitness traits

    Allen, D. E. & Little, T. J., 27 Jul 2010, In: Evolutionary Ecology Research. 25, 2, p. 499-508 10 p.

    Research output: Contribution to journalArticlepeer-review

  44. CRISPR-mediated phage resistance and the ghost of coevolution past

    Vale, P. & Little, T. J., 22 Jul 2010, In: Proceedings of the Royal Society B-Biological Sciences. 277, 1691, p. 2097-2103 7 p.

    Research output: Contribution to journalLiterature reviewpeer-review

  45. 2009
  46. Parasitism and environmental sex determination in Daphnia

    Duncan, A. B., Hall, S. A. & Little, T. J., 30 Sep 2009, In: Evolutionary Ecology Research. 11, 6, p. 965-973 9 p.

    Research output: Contribution to journalArticlepeer-review

  47. An ancient immunity gene duplication in Daphnia magna: RNA expression and sequence analysis of two nitric oxide synthase genes

    Labbe, P., McTaggart, S. J. & Little, T. J., Sep 2009, In: Developmental and Comparative Immunology. 33, 9, p. 1000-1010 11 p.

    Research output: Contribution to journalArticlepeer-review

  48. Measuring parasite fitness under genetic and thermal variation

    Vale, P. F. & Little, T. J., Aug 2009, In: Heredity. 103, 2, p. 102-109 8 p.

    Research output: Contribution to journalArticlepeer-review

  49. Inferring selection in the Anopheles gambiae species complex: an example from immune-related serine protease inhibitors

    Obbard, D. J., Welch, J. J. & Little, T. J., 4 Jun 2009, In: Malaria Journal. 8, p. - 15 p., 117.

    Research output: Contribution to journalArticlepeer-review

  50. ProPhenolOxidase in Daphnia magna: cDNA sequencing and expression in relation to resistance to pathogens

    Labbe, P. & Little, T. J., 31 May 2009, In: Developmental and Comparative Immunology. 33, 5, p. 674-680 7 p.

    Research output: Contribution to journalArticlepeer-review

  51. Nucleotide Polymorphism and Within-Gene Recombination in Daphnia magna and D. pulex, Two Cyclical Parthenogens

    Haag, C. R., McTaggart, S. J., Didier, A., Little, T. J. & Charlesworth, D., May 2009, In: Genetics. 182, 1, p. 313-323 11 p.

    Research output: Contribution to journalArticlepeer-review

  52. The components of the Daphnia pulex immune system as revealed by complete genome sequencing

    McTaggart, S. J., Conlon, C., Colbourne, J. K., Blaxter, M. L. & Little, T. J., 22 Apr 2009, In: BMC Genomics. 10, p. 175 19 p., 175.

    Research output: Contribution to journalArticlepeer-review

  53. Immunity in a variable world

    Lazzaro, B. P. & Little, T. J., 12 Jan 2009, In: Philosophical Transactions of the Royal Society B: Biological Sciences. 364, 1513, p. 15-26 12 p.

    Research output: Contribution to journalLiterature reviewpeer-review

  54. 2008
  55. Male three-spined sticklebacks Gasterosteus aculeatus make antibiotic nests: a novel form of parental protection?

    Little, T. J., Perutz, M., Palmer, M., Crossan, C. & Braithwaite, V. A., Dec 2008, In: Journal of Fish Biology. 73, 10, p. 2380-2389 10 p.

    Research output: Contribution to journalArticlepeer-review

  56. Deforestation and vectorial capacity of Anopheles gambiae giles mosquitoes in malaria transmission, Kenya

    Afrane, Y. A., Little, T. J., Lawson, B. W., Githeko, A. K. & Yan, G., Oct 2008, In: Emerging Infectious Diseases. 14, 10, p. 1533-1538 6 p.

    Research output: Contribution to journalArticlepeer-review

  57. An animal model to evaluate the function and regulation of the adaptively evolving stress protein SEP53 in oesophageal bile damage responses

    Nelson, L., Anderson, S., Archibald, A. L., Rhind, S., Lu, Z. H., Condie, A., Macintyre, N., Thompson, J., Nenutil, R., Vojtesek, B., Whitelaw, C. B., Little, T. J. & Hupp, T., Sep 2008, In: Cell Stress and Chaperones. 13, 3, p. 375-385 11 p.

    Research output: Contribution to journalArticlepeer-review

  58. Temperature-dependent costs of parasitism and maintenance of polymorphism under genotype-by-environment interactions

    Vale, P., Stjernman, M. & Little, T. J., Sep 2008, In: Journal of Evolutionary Biology. 21, 5, p. 1418-1427 10 p.

    Research output: Contribution to journalArticlepeer-review

  59. The Dscam homologue of the crustacean Daphnia is diversified by alternative splicing like in insects

    Brites, D., McTaggart, S., Morris, K., Anderson, J., Thomas, K., Colson, I., Fabbro, T., Little, T. J., Ebert, D. & Du Pasquier, L., Jul 2008, In: Molecular Biology and Evolution. 25, 7, p. 1429-1439 11 p.

    Research output: Contribution to journalArticlepeer-review

  60. Studying immunity at the whole organism level

    Little, T., Colegrave, N., Sadd, B. M. & Schmid-Hempel, P., Apr 2008, In: BioEssays. 30, 4, p. 404-405 2 p.

    Research output: Contribution to journalLetterpeer-review

  61. Parasite variation and the evolution of virulence in a Daphnia-microparasite system

    Little, T. J., Chadwick, W. & Watt, K., Mar 2008, In: Parasitology. 135, 3, p. 303-308 6 p.

    Research output: Contribution to journalArticlepeer-review

  62. Parasitism and breeding system variation in North American populations of Daphnia pulex

    Killick, S. C., Obbard, D. J., West, S. A. & Little, T., Jan 2008, In: Ecological Research. 23, 1, p. 235-240 6 p.

    Research output: Contribution to journalArticlepeer-review

  63. Dialogue on defenses: Report from the workshop on "the impact of the environment on innate immunity: At the defence frontier", 22-27 April 2007

    Carpenter, J. A., Jiggins, F. M. & Little, T. J., 2008, In: Developmental and Comparative Immunology. 32, 3, p. 307-309 3 p.

    Research output: Contribution to journalEditorialpeer-review

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