Edinburgh Research Explorer

Dr Veronique Miron

Senior Lecturer, Principal Investigator/ Lecturer

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Willingness to take PhD students: Yes

N/A

Education/Academic qualification

Doctor of Philosophy (PhD), McGill University, Montreal
Effects of CNS accessible multiple sclerosis-directed immunomodulatory therapies on oligodendrocyte lineage cells and remyelination
Bachelor of Science, McGill University, Montreal

Area of Expertise

Research expertiseMyelination, Remyelination, Multiple Sclerosis, Cerebral Palsy, Perinatal brain injury, White matter, Inflammation, Microglia, Macrophages

Biography

Veronique Miron obtained her PhD in 2009 in Neurological Sciences from McGill University (Canada), funded by studentships from the Natural Sciences and Engineering Research Council and the Canadian Institutes of Health Research, and was awarded the European Charcot Foundation Young Investigator Award. Following a brief postodoc in Neuroimmunology at the Montreal Neurological Institute, she carried out a postdoc in Regenerative Medicine at The Scottish Centre for Regenerative Medicine, funded by the Multiple Sclerosis Society of Canada. In 2014, she was appointed as Lecturer in the MRC Centre for Reproductive Health and is currently an MRC/ MS Society career development fellow.

Veronique’s research focuses on investigating the regenerative properties of inflammation to drive central nervous system white matter regeneration, with implications for neurological disorders with high worldwide prevalence (such as cerebral palsy and MS).  She has >12 years of research experience in regenerative medicine, myelin biology and neuroimmunology, including proficiency developing and applying in vitro/ ex vivo/ in vivo modelling of neurological disease, transgenic approaches, advanced imaging platforms, high through-put imaging/analysis, and neuropathological analysis. She has authored 23 publications, including 6 first-author peer-reviewed manuscripts (including in Nature Neuroscience and Annals of Neurology) and 10 invited review articles/ book chapters/ editorial, cited 1500 times.

Current Research Interests

  • The role of microglia/ macrophage activation in regeneration of myelin in the central nervous system
  • Dysregulation of microglia/ macrophage activation & their secreted products in neurological disorders such as perinatal brain injury/ cerebral palsy and multiple sclerosis
  • Distinct contributions of endogenous vs recruited macrophages in central nervous system regeneration
  • Comparison of the inflammatory and regenerative mechanisms following injury in developing vs adult central nervous system
  • Discovery of novel therapeutic targets that promote myelin regeneration in neurological disorders

My research in a nutshell

The research group is taking a novel approach to identifying new strategies to promote central nervous system myelin regeneration in neurological disorders by harnessing the regenerative properties of inflammation, in particular, macrophages (including CNS-resident microglia). Although macrophages have traditionally been implicated in inducing central nervous system injury, our recent studies show that anti-inflammatory macrophages drive myelin regeneration in thebrain. Our overarching goal is to build on these findings to develop new strategies to promote myelin generation following brain injury, by manipulating macrophage activation and identifying the regenerative factors they produce.

Administrative Roles

  • MRC Centre for Reproductive Health Postgraduate Committee Member (2016-present)
  • Head of Postgraduate Committee for Athena Swan Career Equality and Progression working group for College of Medicine and Veterinary Medicine (2016-present)

Biography

  • MRC Centre for Reproductive Health Postgraduate Committee Member (2016-present)
  • Head of Postgraduate Committee for Athena Swan Career Equality and Progression working group for College of Medicine and Veterinary Medicine (2016-present)
  • M.Sc. in Reproductive Sciences Exam Board member

Research activities & awards

  1. Speaker

    Activity: Academic talk or presentation typesInvited talk

  2. Immunity and remyelination

    Activity: Academic talk or presentation typesInvited talk

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