Edinburgh Research Explorer

Veronique Miron

Senior Lecturer, Principal Investigator/ Senior Lecturer

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Willingness to take PhD students: Yes

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Education/Academic qualification

Doctor of Philosophy (PhD), McGill University, Montreal
Effects of CNS accessible multiple sclerosis-directed immunomodulatory therapies on oligodendrocyte lineage cells and remyelination
Bachelor of Science, McGill University, Montreal

Area of Expertise

Research expertiseMyelination, Remyelination, Multiple Sclerosis, Cerebral Palsy, Perinatal brain injury, White matter, Inflammation, Microglia, Macrophages

Biography

Veronique Miron obtained her PhD in 2009 in Neurological Sciences from McGill University (Canada), funded by studentships from the Natural Sciences and Engineering Research Council and the Canadian Institutes of Health Research, and was awarded the European Charcot Foundation Young Investigator Award. She then carried out a postdoc in Regenerative Medicine at The Scottish Centre for Regenerative Medicine, funded by a fellowship from the Multiple Sclerosis Society of Canada. Being awarded a Career Development Award from the Medical Research Council and the United Kingdom MS Society, she took up an independent position in the MRC Centre for Reproductive Health.

Dr.Miron has >16 years of research experience in regenerative medicine, myelin biology and neuroimmunology, including proficiency developing and applying in vitro/ ex vivo/ in vivo modelling of neurological disease, transgenic approaches, advanced imaging platforms, high through-put imaging/analysis, omics, and neuropathological analysis. She has contributed to 20 original research publications, including senior author manuscripts in Nature Neuroscience and Acta Neuropathologica. 

Current Research Interests

  • The role of microglia in developmental myelination, and disrupted myelination following perinatal brain injury leading to cerebral palsy
  • The role of microglia in regeneration of myelin following injury (e.g. multiple sclerosis), and the contribution of other immune cells which impact or complement microglia function in this context.
  • The role of microglia in myelin homeostasis in adulthood and ageing, and how this contributes to neuronal and cognitive decline.

My research in a nutshell

Dr.Miron’s lab focuses on harnessing the regenerative properties of inflammation to support central nervous system myelin health across the lifespan. Myelin is critical for neuronal health and function and its dysregulation contributes to common neurological conditions such as cerebral palsy, multiple sclerosis, and cognitive decline in ageing. More specifically, Dr.Miron's lab focuses on how central nervous system resident macrophages (microglia) support myelin heath, by answering the following questions:

1) DEVELOPMENT: How do central nervous system resident macrophages (microglia) support myelin formation in development? How is this disrupted following injury to the developing brain?

2) ADULTHOOD: How do microglia support the regeneration of myelin following injury? What other immune cells impact or complement their function in this context?

3) AGEING: How do microglia support myelin health in homeostasis and with ageing? How does this contribute to function e.g. cognitive decline?

Dr.Miron's lab uses a breadth of approaches to answer these questions, such as RNA sequencing (bulk, single-cell, translatome), digital spatial profiling, bioinformatics, human tissue analysis, mouse transgenics, in vivo mouse models, ex vivo mouse brain explants, in vitro human and mouse cell cultures, high throughput cell profiling and drug screening, microscopy (confocal, slide scanning, electron), molecular analyses and manipulation, and bioengineering drug delivery approaches.

 

Administrative Roles

  • MRC Centre for Reproductive Health Postgraduate Committee Member (2016-present)
  • Centre representative for Wellcome Trust Tissue Repair PhD program (2019-present)
  • Head of Postgraduate Committee for Athena Swan Career Equality and Progression working group for College of Medicine and Veterinary Medicine (2016-present)
  • Thesis committee chair for 2 PhD students and committee member for additional 6
  • Exam board member for Centre for Reproductive Health MSc program (2015-2018)
  • Founder and organizer of Microglia club (2017-present)
  • Internal examiner for 3 PhD vivas and external examiner for 4 PhD vivas
  • Editorial board member for journal Multiple Sclerosis (2018-present)
  • Guest Editor for Frontiers in Cell and Developmental Biology (2016)
  • Programme committee for international conference Euroglia (2017) and local organizing committee for 3 conferences (2015, 2017, 2019)

Highlighted research outputs

  1. Central nervous system regeneration is driven by microglia necroptosis and repopulation

    Research output: Contribution to journalArticlepeer-review

  2. The pro-remyelination properties of microglia in the central nervous system

    Research output: Contribution to journalReview articlepeer-review

  3. Activin receptors regulate the oligodendrocyte lineage in health and disease

    Research output: Contribution to journalArticlepeer-review

View all (45) »

Research activities & awards

  1. Consultancy for Novartis (Headquarters)

    Activity: Consultancy typesConsultancy

  2. Consultancy for Frazier Life Sciences

    Activity: Consultancy typesConsultancy

  3. ACTRIMS - West Palm Beach

    Activity: Academic talk or presentation typesInvited talk

View all (112) »

Latest prizes

  1. Suffrage Science Award

    Prize: Prize (including medals and awards)

View all (1) »

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