Edinburgh Research Explorer

Dr Veronique Miron

Senior Lecturer, Principal Investigator/ Senior Lecturer

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Willingness to take PhD students: Yes

N/A

Education/Academic qualification

Doctor of Philosophy (PhD), McGill University, Montreal
Effects of CNS accessible multiple sclerosis-directed immunomodulatory therapies on oligodendrocyte lineage cells and remyelination
Bachelor of Science, McGill University, Montreal

Area of Expertise

Research expertiseMyelination, Remyelination, Multiple Sclerosis, Cerebral Palsy, Perinatal brain injury, White matter, Inflammation, Microglia, Macrophages

Biography

Veronique Miron obtained her PhD in 2009 in Neurological Sciences from McGill University (Canada), funded by studentships from the Natural Sciences and Engineering Research Council and the Canadian Institutes of Health Research, and was awarded the European Charcot Foundation Young Investigator Award. She then carried out a postdoc in Regenerative Medicine at The Scottish Centre for Regenerative Medicine, funded by a fellowship from the Multiple Sclerosis Society of Canada. Being awarded a Career Development Award from the Medical Research Council and the United Kingdom MS Society, she took up an independent position in the MRC Centre for Reproductive Health.

Dr.Miron has >15 years of research experience in regenerative medicine, myelin biology and neuroimmunology, including proficiency developing and applying in vitro/ ex vivo/ in vivo modelling of neurological disease, transgenic approaches, advanced imaging platforms, high through-put imaging/analysis, omics, and neuropathological analysis. She has authored 19 research publications, including senior author manuscripts in Nature Neuroscience and Acta Neuropathologica. 

Current Research Interests

  • The role of microglia/ macrophage activation in health and regeneration of myelin in the central nervous system
  • Dysregulation of microglia/ macrophage activation & their secreted products in neurological disorders such as perinatal brain injury/ cerebral palsy and multiple sclerosis
  • Distinct contributions of endogenous vs recruited macrophages in central nervous system regeneration
  • Comparison of the inflammatory and regenerative mechanisms following injury in developing vs adult central nervous system
  • Discovery of novel therapeutic targets that promote myelin regeneration in neurological disorders

My research in a nutshell

Dr.Miron’s lab focuses on harnessing the regenerative properties of inflammation to drive central nervous system regeneration. More specifically, regeneration of the insulation surrounding nerve fibres, termed myelin, is required for nerve health and function. Failed myelin regeneration occurs in neurological disorders across the lifespan such as cerebral palsy and multiple sclerosis. Her lab has made notable contributions to understanding how central nervous system resident macrophages (microglia) contribute to myelin health, and the molecular mechanisms underpinning this function. The overarching goal is to build on these findings to develop new strategies to promote myelin health following brain injury, by manipulating microglia/macrophage activation and identifying the regenerative factors they produce.

Administrative Roles

  • MRC Centre for Reproductive Health Postgraduate Committee Member (2016-present)
  • Centre representative for Wellcome Trust Tissue Repair PhD program (2019-present)
  • Head of Postgraduate Committee for Athena Swan Career Equality and Progression working group for College of Medicine and Veterinary Medicine (2016-present)
  • Thesis committee chair for 2 PhD students and committee member for additional 6
  • Exam board member for Centre for Reproductive Health MSc program (2015-2018)
  • Founder and organizer of Microglia club (2017-present)
  • Internal examiner for 2 PhD vivas and external examiner for 3 PhD vivas
  • Editorial board member for journal Multiple Sclerosis (2018-present)
  • Guest Editor for Frontiers in Cell and Developmental Biology (2016)
  • Programme committee for international conference Euroglia (2017) and local organizing committee for 3 conferences (2015, 2017, 2019)

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