Project relations

• Improving Later Life - Health Cognitive Ageing

  Project: University Awarded Project Funding

Activities

• Medical Image Understanding and Analysis (MIUA 2016)

  Activity: Participating in or organising an event types › Participation in conference

• SINAPSE Annual Scientific Meeting 2016

  Activity: Participating in or organising an event types › Participation in workshop, seminar, course

Research outputs

• Resting-State Connectivity and Its Association With Cognitive Performance, Educational Attainment, and Household Income in the UK Biobank

  Research output: Contribution to journal › Article

• DNA methylation and the epigenetic clock in relation to physical frailty in older people: The Lothian Birth Cohort 1936

  Research output: Contribution to journal › Article

• Machine learning of neuroimaging for assisted diagnosis of cognitive impairment and dementia: A systematic review

  Research output: Contribution to journal › Review article

• Polygenic risk score for schizophrenia and structural brain connectivity in older age: A longitudinal connectome and tractography study

  Research output: Contribution to journal › Article

• Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries

  Research output: Contribution to journal › Article

• The association between carotid atheroma and cerebral cortex structure at age 73

  Research output: Contribution to journal › Article

• An epigenetic score for BMI based on DNA methylation correlates with poor physical health and major disease in the Lothian Birth Cohort

  Research output: Contribution to journal › Article

• Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting

  Research output: Contribution to journal › Article

• Total MRI load of cerebral small vessel disease and cognitive ability in older people

  Research output: Contribution to journal › Article

• Volumetric and correlational implications of brain parcellation method selection: a 3-way comparison in the frontal lobes.

  Research output: Contribution to journal › Article

• Neural correlates of Trail Making Test performance in older adults: the Lothian Birth Cohort 1936

  Research output: Contribution to conference › Poster

• Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence

  Research output: Contribution to journal › Article

• Genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume

  Research output: Contribution to journal › Article

• Systems genetics identifies a convergent gene network for cognition and neurodevelopmental disease

  Research output: Contribution to journal › Article

• Progression of white matter disease and cortical thinning are not related in older community-dwelling subjects

  Research output: Contribution to journal › Article

• 3D shape analysis of the brain's third ventricle using a midplane encoded symmetric template model

  Research output: Contribution to journal › Article

• Brain age and other bodily ‘ages’: Implications for neuropsychiatry

  Research output: Contribution to journal › Article

• Longitudinal telomere length shortening and cognitive and physical decline in later life: The Lothian Birth Cohorts 1936 and 1921

  Research output: Contribution to journal › Article

• Application of the ordered logit model to optimising Frangi filter parameters for segmentation of perivascular spaces

  Research output: Contribution to journal › Article

• On the computational assessment of white matter hyperintensity progression: difficulties in method selection and bias field correction performance on images with significant white matter pathology

  Research output: Contribution to journal › Article

• Reverse causation in activity-cognitive ability associations: The Lothian Birth Cohort 1936

  Research output: Contribution to journal › Article

• Do white matter hyperintensities mediate the association between brain iron deposition and cognitive abilities in older people?

  Research output: Contribution to journal › Article

• Vascular risk factors and progression of white matter hyperintensities in the Lothian Birth Cohort 1936

  Research output: Contribution to journal › Article

• Associations between education and brain structure at age 73 years, adjusted for age 11 IQ

  Research output: Contribution to journal › Article

• ENIGMA and the individual: Predicting factors that affect the brain in 35 countries worldwide

  Research output: Contribution to journal › Article

• William M. Feinberg Award for Excellence in Clinical Stroke: Small Vessel Disease; a Big Problem, But Fixable

  Research output: Contribution to journal › Article

• Do Cognitive and Physical Functions Age in Concert from Age 70 to 76? Evidence from the Lothian Birth Cohort 1936

  Research output: Contribution to journal › Article

• Ageing and brain white matter structure in 3513 UK Biobank participants

  Research output: Contribution to journal › Article

• Getting Spearman off the skyhook: One more in a century (since Thomson, 1916) of attempts to vanquish g

  Research output: Contribution to journal › Article

• Genetic Variants in CETP Increase Risk of Intracerebral Hemorrhage

  Research output: Contribution to journal › Article

• Early life characteristics and late life burden of cerebral small vessel disease in the Lothian Birth Cohort 1936

  Research output: Contribution to journal › Article

• A protocol for precise comparisons of small vessel disease lesions between ex vivo magnetic resonance imaging and histopathology

  Research output: Contribution to journal › Article

• Trait Conscientiousness and the Personality Meta-Trait Stability are Associated with Regional White Matter Microstructure

  Research output: Contribution to journal › Article

• A latent measure explains substantial variance in white matter microstructure across the newborn human brain

  Research output: Contribution to journal › Article

• Epigenetic prediction of complex traits and death

  Research output: Contribution to journal › Article

• Risk and protective factors for structural brain ageing in the eighth decade of life

  Research output: Contribution to journal › Article

• Associations of intelligence across the life course with optimism and pessimism in older age

  Research output: Contribution to journal › Article

• Interaction of APOE e4 and poor glycemic control predicts white matter hyperintensity growth from 73-76

  Research output: Contribution to journal › Article

• Intergenerational social mobility and subjective wellbeing in later life

  Research output: Contribution to journal › Article

• Dietary iodine exposure and brain structures and cognition in older people. Exploratory analysis in the Lothian Birth Cohort 1936

  Research output: Contribution to journal › Article

• Brain grey and white matter predictors of verbal ability traits in older age: The Lothian Birth Cohort 1936

  Research output: Contribution to journal › Article

• Associations between hippocampal morphology, diffusion characteristics, and salivary cortisol in older men

  Research output: Contribution to journal › Article

• Cognitive abilities in later life and the onset of physical frailty: The Lothian Birth Cohort 1936

  Research output: Contribution to journal › Article

• The influence of neighbourhoods and the social environment on sedentary behaviour in older adults in three prospective cohorts

  Research output: Contribution to journal › Special issue

• Relationships between socioeconomic position and objectively measured sedentary behaviour in older adults in three prospective cohorts

  Research output: Contribution to journal › Article

• Individual differences in cognitive processes underlying Trail Making Test-B performance in old age: The Lothian Birth Cohort 1936

  Research output: Contribution to journal › Article

• Sleep and cognitive aging in the eighth decade of life

  Research output: Contribution to journal › Article

• Childhood intelligence in relation to major causes of death in 68 year follow-up: Prospective population study

  Research output: Contribution to journal › Article

• Rare disruptive variants in the DISC1 Interactome and Regulome: association with cognitive ability and schizophrenia

  Research output: Contribution to journal › Article

• Brain cortical characteristics of lifetime cognitive ageing

  Research output: Contribution to journal › Article

• Genetic contributions to trail making test performance in UK Biobank

  Research output: Contribution to journal › Article

• Processing speed and the relationship between Trail Making Test-B performance, cortical thinning and white matter microstructure in older adults

  Research output: Contribution to journal › Article

• Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney

  Research output: Contribution to journal › Article

• Retinal microvascular network geometry and cognitive abilities in community-dwelling older people: The Lothian Birth Cohort 1936 Study

  Research output: Contribution to journal › Article

• Subcortical volume and white matter integrity abnormalities in major depressive disorder: Findings from UK Biobank imaging data

  Research output: Contribution to journal › Article

• Metric to quantify white matter damage on brain magnetic resonance images

  Research output: Contribution to journal › Article

• New blood pressure–associated loci Identified in meta-analyses of 475 000 individuals

  Research output: Contribution to journal › Article

• Cognitive abilities, brain white matter hyperintensity volume and structural network connectivity in older age.

  Research output: Contribution to journal › Article

• Assessing amyloid-β, tau, and glial features in Lothian Birth Cohort 1936 participants post-mortem

  Research output: Contribution to journal › Article

• Identification of a novel locus on chromosome 2q13 which predisposes to clinical vertebral fractures independently of bone density

  Research output: Contribution to journal › Article

• DNA methylation analysis identifies loci for blood pressure regulation

  Research output: Contribution to journal › Article

• Cognitive ability does not predict objectively measured sedentary behaviour: Evidence from three older cohorts

  Research output: Contribution to journal › Article

• Brain age predicts mortality

  Research output: Contribution to journal › Article

• Coupled changes in hippocampal structure and cognitive ability in later life

  Research output: Contribution to journal › Article

• An epigenome-wide association study meta-analysis of educational attainment

  Research output: Contribution to journal › Article

• Brain structural differences between 73- and 92-year olds matched for childhood intelligence, social background, and intracranial volume

  Research output: Contribution to journal › Article

• Age-related gene expression changes, and transcriptome wide association study of physical and cognitive aging traits, in the Lothian Birth Cohort 1936

  Research output: Contribution to journal › Article

• The epigenetic clock and objectively measured sedentary and walking behaviour in older adults: The Lothian Birth Cohort 1936

  Research output: Contribution to journal › Article

• Integrative analysis of omics summary data reveals putative mechanisms underlying complex traits

  Research output: Contribution to journal › Article

• What do older people do when sitting and why? Implications for decreasing sedentary behavior

  Research output: Contribution to journal › Article

• Predictors of gait speed and its change over three years in community-dwelling older people

  Research output: Contribution to journal › Article

• Perivascular Spaces Segmentation in Brain MRI Using Optimal 3D Filtering

  Research output: Contribution to journal › Article

• DNA methylation and all-cause mortality in middle-aged and elderly Danish twins

  Research output: Contribution to journal › Article

• Tracking the epigenetic clock across the human life course: A meta-analysis of longitudinal cohort data

  Research output: Contribution to journal › Article

• Cognitive ability does not predict objectively measured sedentary behaviour: Evidence from three older cohorts

  Research output: Contribution to journal › Article

• Apolipoprotein E genotype does not moderate the associations of depressive symptoms, neuroticism and allostatic load with cognitive ability and cognitive aging in the Lothian Birth Cohort 1936

  Research output: Contribution to journal › Article

• Systematic comparative validation of self-report measures of sedentary time against an objective measure of postural sitting (activPAL)

  Research output: Contribution to journal › Article

• GWAS of epigenetic aging rates in blood reveals a critical role for TERT

  Research output: Contribution to journal › Article

• Widespread associations between trait conscientiousness and thickness of brain cortical regions

  Research output: Contribution to journal › Article

• Predicting change in quality of life from age 79 to 90 in the Lothian Birth Cohort 1921

  Research output: Contribution to journal › Article

• Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood

  Research output: Contribution to journal › Article

• Cognitive function in early and later life is associated with blood glucose in older individuals: Analysis of the Lothian Birth Cohort of 1936

  Research output: Contribution to journal › Article

• Trajectories of inflammatory biomarkers over the eighth decade and their associations with immune cell profiles and epigenetic ageing

  Research output: Contribution to journal › Article

• Longitudinal multi-centre brain imaging studies: guidelines and practical tips for accurate and reproducible imaging endpoints and data sharing

  Research output: Contribution to journal › Article

• Association of whole-genome and NETRIN1 signaling pathway-derived polygenic risk scores for Major Depressive Disorder and white matter microstructure in UK Biobank

  Research output: Contribution to journal › Article

• Longitudinal serum S100β and brain ageing in the Lothian Birth Cohort 1936

  Research output: Contribution to journal › Article

• Exome chip analysis identifies low-frequency and rare variants in MRPL38 for white matter hyperintensities on brain MRI

  Research output: Contribution to journal › Article

• Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci

  Research output: Contribution to journal › Article

• Association between APOE e4 and white matter hyperintensity volume, but not total brain volume or white matter integrity

  Research output: Contribution to journal › Article

• Associations between vascular risk factors and brain MRI indices in UK Biobank

  Research output: Contribution to journal › Article

• Association of apolipoprotein E with intracerebral hemorrhage risk by race/ethnicity: A meta-analysis

  Research output: Contribution to journal › Article

• GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes

  Research output: Contribution to journal › Article

• Retinal microvasculature and cerebral small vessel disease in the Lothian Birth Cohort 1936 and Mild Stroke Study

  Research output: Contribution to journal › Article

• Identification of the presence of ischaemic stroke lesions by means of texture analysis on brain magnetic resonance images

  Research output: Contribution to journal › Article

• Corticosteroids and regional variations in thickness of the human cerebral cortex across the lifespan

  Research output: Contribution to journal › Article

• Perivascular spaces in the centrum semiovale at the beginning of the 8th decade of life: Effect on cognition and associations with mineral deposition

  Research output: Contribution to journal › Article

• Fluctuating asymmetry in brain structure and general intelligence in 73-Year-olds

  Research output: Contribution to journal › Article

• An epigenetic predictor of death captures multi-modal measures of brain health

  Research output: Contribution to journal › Article

• Epigenetic signatures of smoking associate with cognitive function, brain structure, and mental and physical health outcomes in the Lothian Birth Cohort 1936

  Research output: Contribution to journal › Article

• Spatial Gradient of Microstructural Changes in Normal-Appearing White Matter in Tracts Affected by White Matter Hyperintensities in Older Age

  Research output: Contribution to journal › Article

• Physical frailty and decline in general and specific cognitive abilities: The Lothian Birth Cohort 1936

  Research output: Contribution to journal › Article

• Brain peak width of skeletonised mean diffusivity (PSMD) and cognitive function in later life

  Research output: Contribution to journal › Article

• Structural brain imaging correlates of general intelligence in UK Biobank

  Research output: Contribution to journal › Article

• Sleep and brain morphological changes in the eighth decade of life

  Research output: Contribution to journal › Article

• The effect of network thresholding and weighting on structural brain networks in the UK Biobank

  Research output: Contribution to journal › Article

• The genetic architecture of the human cerebral cortex

  Research output: Contribution to journal › Article

• Computational quantification of brain perivascular space morphologies: Associations with vascular risk factors and white matter hyperintensities. A study in the Lothian Birth Cohort 1936

  Research output: Contribution to journal › Article

• Genetic architecture of subcortical brain structures in 38,851 individuals

  Research output: Contribution to journal › Article

• Epigenome-wide meta-analyses of blood DNA methylation and its association with subcortical volumes: Findings from the ENIGMA Epigenetics Working Group

  Research output: Contribution to journal › Article

• Neurology-related protein biomarkers are associated with cognitive ability and brain volume in older age

  Research output: Contribution to journal › Article

• Global and regional development of the human cerebral cortex: Molecular architecture and occupational aptitudes

  Research output: Contribution to journal › Article

• Aging-sensitive networks within the human structural connectome are implicated in late-life cognitive declines.

  Research output: Contribution to journal › Article

• Inflammation as a risk factor for the development of frailty in the Lothian Birth Cohort 1936

  Research output: Contribution to journal › Article

• Age-Related Changes of Peak Width Skeletonized Mean Diffusivity (PSMD) Across the Adult Lifespan: A Multi-Cohort Study

  Research output: Contribution to journal › Article

• Common Genetic Variation Indicates Separate Causes for Periventricular and Deep White Matter Hyperintensities

  Research output: Contribution to journal › Article