Brain imaging and cognitive ageing in the Lothian Birth Cohort 1936: III

Project: Research

Wardlaw, Joanna (Principal Investigator)
Bastin, Mark (Co-investigator)
Deary, Ian (Co-investigator)

Status	Finished
Effective start/end date	1/05/15 → 30/04/19

Total award	£502,940.00
Funding organisation	MRC
Funder project reference	MR/M013111/1

Total award	£812,520.00
Funding organisation	MRC
Funder project reference	MR/M013111/1

Period	1/05/15 → 30/04/19

Project relations

Improving Later Life - Health Cognitive Ageing
Project: University Awarded Project Funding

Activities

Medical Image Understanding and Analysis (MIUA 2016)
Activity: Participating in or organising an event types › Participation in conference
SINAPSE Annual Scientific Meeting 2016
Activity: Participating in or organising an event types › Participation in workshop, seminar, course

Research outputs

Resting-State Connectivity and Its Association With Cognitive Performance, Educational Attainment, and Household Income in the UK Biobank
Research output: Contribution to journal › Article
DNA methylation and the epigenetic clock in relation to physical frailty in older people: The Lothian Birth Cohort 1936
Research output: Contribution to journal › Article
Machine learning of neuroimaging for assisted diagnosis of cognitive impairment and dementia: A systematic review
Research output: Contribution to journal › Review article
Polygenic risk score for schizophrenia and structural brain connectivity in older age: A longitudinal connectome and tractography study
Research output: Contribution to journal › Article
Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries
Research output: Contribution to journal › Article
The association between carotid atheroma and cerebral cortex structure at age 73
Research output: Contribution to journal › Article
An epigenetic score for BMI based on DNA methylation correlates with poor physical health and major disease in the Lothian Birth Cohort
Research output: Contribution to journal › Article
Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting
Research output: Contribution to journal › Article
Total MRI load of cerebral small vessel disease and cognitive ability in older people
Research output: Contribution to journal › Article
Volumetric and correlational implications of brain parcellation method selection: a 3-way comparison in the frontal lobes.
Research output: Contribution to journal › Article
Neural correlates of Trail Making Test performance in older adults: the Lothian Birth Cohort 1936
Research output: Contribution to conference › Poster
Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence
Research output: Contribution to journal › Article
Genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume
Research output: Contribution to journal › Article
Systems genetics identifies a convergent gene network for cognition and neurodevelopmental disease
Research output: Contribution to journal › Article
Progression of white matter disease and cortical thinning are not related in older community-dwelling subjects
Research output: Contribution to journal › Article
3D shape analysis of the brain's third ventricle using a midplane encoded symmetric template model
Research output: Contribution to journal › Article
Brain age and other bodily ‘ages’: Implications for neuropsychiatry
Research output: Contribution to journal › Article
Longitudinal telomere length shortening and cognitive and physical decline in later life: The Lothian Birth Cohorts 1936 and 1921
Research output: Contribution to journal › Article
Application of the ordered logit model to optimising Frangi filter parameters for segmentation of perivascular spaces
Research output: Contribution to journal › Article
On the computational assessment of white matter hyperintensity progression: difficulties in method selection and bias field correction performance on images with significant white matter pathology
Research output: Contribution to journal › Article
Reverse causation in activity-cognitive ability associations: The Lothian Birth Cohort 1936
Research output: Contribution to journal › Article
Do white matter hyperintensities mediate the association between brain iron deposition and cognitive abilities in older people?
Research output: Contribution to journal › Article
Vascular risk factors and progression of white matter hyperintensities in the Lothian Birth Cohort 1936
Research output: Contribution to journal › Article
Associations between education and brain structure at age 73 years, adjusted for age 11 IQ
Research output: Contribution to journal › Article
ENIGMA and the individual: Predicting factors that affect the brain in 35 countries worldwide
Research output: Contribution to journal › Article
William M. Feinberg Award for Excellence in Clinical Stroke: Small Vessel Disease; a Big Problem, But Fixable
Research output: Contribution to journal › Article
Do Cognitive and Physical Functions Age in Concert from Age 70 to 76? Evidence from the Lothian Birth Cohort 1936
Research output: Contribution to journal › Article
Ageing and brain white matter structure in 3513 UK Biobank participants
Research output: Contribution to journal › Article
Getting Spearman off the skyhook: One more in a century (since Thomson, 1916) of attempts to vanquish g
Research output: Contribution to journal › Article
Genetic Variants in CETP Increase Risk of Intracerebral Hemorrhage
Research output: Contribution to journal › Article
Early life characteristics and late life burden of cerebral small vessel disease in the Lothian Birth Cohort 1936
Research output: Contribution to journal › Article
A protocol for precise comparisons of small vessel disease lesions between ex vivo magnetic resonance imaging and histopathology
Research output: Contribution to journal › Article
Trait Conscientiousness and the Personality Meta-Trait Stability are Associated with Regional White Matter Microstructure
Research output: Contribution to journal › Article
A latent measure explains substantial variance in white matter microstructure across the newborn human brain
Research output: Contribution to journal › Article
Epigenetic prediction of complex traits and death
Research output: Contribution to journal › Article
Risk and protective factors for structural brain ageing in the eighth decade of life
Research output: Contribution to journal › Article
Associations of intelligence across the life course with optimism and pessimism in older age
Research output: Contribution to journal › Article
Interaction of APOE e4 and poor glycemic control predicts white matter hyperintensity growth from 73-76
Research output: Contribution to journal › Article
Intergenerational social mobility and subjective wellbeing in later life
Research output: Contribution to journal › Article
Dietary iodine exposure and brain structures and cognition in older people. Exploratory analysis in the Lothian Birth Cohort 1936
Research output: Contribution to journal › Article
Brain grey and white matter predictors of verbal ability traits in older age: The Lothian Birth Cohort 1936
Research output: Contribution to journal › Article
Associations between hippocampal morphology, diffusion characteristics, and salivary cortisol in older men
Research output: Contribution to journal › Article
Cognitive abilities in later life and the onset of physical frailty: The Lothian Birth Cohort 1936
Research output: Contribution to journal › Article
The influence of neighbourhoods and the social environment on sedentary behaviour in older adults in three prospective cohorts
Research output: Contribution to journal › Special issue
Relationships between socioeconomic position and objectively measured sedentary behaviour in older adults in three prospective cohorts
Research output: Contribution to journal › Article
Individual differences in cognitive processes underlying Trail Making Test-B performance in old age: The Lothian Birth Cohort 1936
Research output: Contribution to journal › Article
Sleep and cognitive aging in the eighth decade of life
Research output: Contribution to journal › Article
Childhood intelligence in relation to major causes of death in 68 year follow-up: Prospective population study
Research output: Contribution to journal › Article
Rare disruptive variants in the DISC1 Interactome and Regulome: association with cognitive ability and schizophrenia
Research output: Contribution to journal › Article
Brain cortical characteristics of lifetime cognitive ageing
Research output: Contribution to journal › Article
Genetic contributions to trail making test performance in UK Biobank
Research output: Contribution to journal › Article
Processing speed and the relationship between Trail Making Test-B performance, cortical thinning and white matter microstructure in older adults
Research output: Contribution to journal › Article
Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney
Research output: Contribution to journal › Article
Retinal microvascular network geometry and cognitive abilities in community-dwelling older people: The Lothian Birth Cohort 1936 Study
Research output: Contribution to journal › Article
Subcortical volume and white matter integrity abnormalities in major depressive disorder: Findings from UK Biobank imaging data
Research output: Contribution to journal › Article
Metric to quantify white matter damage on brain magnetic resonance images
Research output: Contribution to journal › Article
New blood pressure–associated loci Identified in meta-analyses of 475 000 individuals
Research output: Contribution to journal › Article
Cognitive abilities, brain white matter hyperintensity volume and structural network connectivity in older age.
Research output: Contribution to journal › Article
Assessing amyloid-β, tau, and glial features in Lothian Birth Cohort 1936 participants post-mortem
Research output: Contribution to journal › Article
Identification of a novel locus on chromosome 2q13 which predisposes to clinical vertebral fractures independently of bone density
Research output: Contribution to journal › Article
DNA methylation analysis identifies loci for blood pressure regulation
Research output: Contribution to journal › Article
Cognitive ability does not predict objectively measured sedentary behaviour: Evidence from three older cohorts
Research output: Contribution to journal › Article
Brain age predicts mortality
Research output: Contribution to journal › Article
Coupled changes in hippocampal structure and cognitive ability in later life
Research output: Contribution to journal › Article
An epigenome-wide association study meta-analysis of educational attainment
Research output: Contribution to journal › Article
Brain structural differences between 73- and 92-year olds matched for childhood intelligence, social background, and intracranial volume
Research output: Contribution to journal › Article
Age-related gene expression changes, and transcriptome wide association study of physical and cognitive aging traits, in the Lothian Birth Cohort 1936
Research output: Contribution to journal › Article
The epigenetic clock and objectively measured sedentary and walking behaviour in older adults: The Lothian Birth Cohort 1936
Research output: Contribution to journal › Article
Integrative analysis of omics summary data reveals putative mechanisms underlying complex traits
Research output: Contribution to journal › Article
What Do Older People Do When Sitting and Why? Implications for Decreasing Sedentary Behavior
Research output: Contribution to journal › Article
Predictors of gait speed and its change over three years in community-dwelling older people
Research output: Contribution to journal › Article
Perivascular Spaces Segmentation in Brain MRI Using Optimal 3D Filtering
Research output: Contribution to journal › Article
DNA methylation and all-cause mortality in middle-aged and elderly Danish twins
Research output: Contribution to journal › Article
Tracking the epigenetic clock across the human life course: A meta-analysis of longitudinal cohort data
Research output: Contribution to journal › Article
Cognitive ability does not predict objectively measured sedentary behaviour: Evidence from three older cohorts
Research output: Contribution to journal › Article
Apolipoprotein E genotype does not moderate the associations of depressive symptoms, neuroticism and allostatic load with cognitive ability and cognitive aging in the Lothian Birth Cohort 1936
Research output: Contribution to journal › Article
Systematic comparative validation of self-report measures of sedentary time against an objective measure of postural sitting (activPAL)
Research output: Contribution to journal › Article
GWAS of epigenetic aging rates in blood reveals a critical role for TERT
Research output: Contribution to journal › Article
Widespread associations between trait conscientiousness and thickness of brain cortical regions
Research output: Contribution to journal › Article
Predicting change in quality of life from age 79 to 90 in the Lothian Birth Cohort 1921
Research output: Contribution to journal › Article
Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood
Research output: Contribution to journal › Article
Cognitive function in early and later life is associated with blood glucose in older individuals: Analysis of the Lothian Birth Cohort of 1936
Research output: Contribution to journal › Article
Trajectories of inflammatory biomarkers over the eighth decade and their associations with immune cell profiles and epigenetic ageing
Research output: Contribution to journal › Article
Longitudinal multi-centre brain imaging studies: guidelines and practical tips for accurate and reproducible imaging endpoints and data sharing
Research output: Contribution to journal › Article
Association of whole-genome and NETRIN1 signaling pathway-derived polygenic risk scores for Major Depressive Disorder and white matter microstructure in UK Biobank
Research output: Contribution to journal › Article
Longitudinal serum S100β and brain ageing in the Lothian Birth Cohort 1936
Research output: Contribution to journal › Article
Exome chip analysis identifies low-frequency and rare variants in MRPL38 for white matter hyperintensities on brain MRI
Research output: Contribution to journal › Article
Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci
Research output: Contribution to journal › Article
Association between APOE e4 and white matter hyperintensity volume, but not total brain volume or white matter integrity
Research output: Contribution to journal › Article
Associations between vascular risk factors and brain MRI indices in UK Biobank
Research output: Contribution to journal › Article
Association of apolipoprotein E with intracerebral hemorrhage risk by race/ethnicity: A meta-analysis
Research output: Contribution to journal › Article
GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes
Research output: Contribution to journal › Article
Retinal microvasculature and cerebral small vessel disease in the Lothian Birth Cohort 1936 and Mild Stroke Study
Research output: Contribution to journal › Article
Identification of the presence of ischaemic stroke lesions by means of texture analysis on brain magnetic resonance images
Research output: Contribution to journal › Article
Corticosteroids and regional variations in thickness of the human cerebral cortex across the lifespan
Research output: Contribution to journal › Article
Perivascular spaces in the centrum semiovale at the beginning of the 8th decade of life: Effect on cognition and associations with mineral deposition
Research output: Contribution to journal › Article
Fluctuating asymmetry in brain structure and general intelligence in 73-Year-olds
Research output: Contribution to journal › Article
An epigenetic predictor of death captures multi-modal measures of brain health
Research output: Contribution to journal › Article
Epigenetic signatures of smoking associate with cognitive function, brain structure, and mental and physical health outcomes in the Lothian Birth Cohort 1936
Research output: Contribution to journal › Article
Spatial Gradient of Microstructural Changes in Normal-Appearing White Matter in Tracts Affected by White Matter Hyperintensities in Older Age
Research output: Contribution to journal › Article
Physical frailty and decline in general and specific cognitive abilities: The Lothian Birth Cohort 1936
Research output: Contribution to journal › Article
Brain peak width of skeletonised mean diffusivity (PSMD) and cognitive function in later life
Research output: Contribution to journal › Article
Structural brain imaging correlates of general intelligence in UK Biobank
Research output: Contribution to journal › Article
Sleep and brain morphological changes in the eighth decade of life
Research output: Contribution to journal › Article
Computational quantification of brain perivascular space morphologies: Associations with vascular risk factors and white matter hyperintensities. A study in the Lothian Birth Cohort 1936
Research output: Contribution to journal › Article
Genetic architecture of subcortical brain structures in 38,851 individuals
Research output: Contribution to journal › Article
Epigenome-wide meta-analyses of blood DNA methylation and its association with subcortical volumes: Findings from the ENIGMA Epigenetics Working Group
Research output: Contribution to journal › Article
Neurology-related protein biomarkers are associated with cognitive ability and brain volume in older age
Research output: Contribution to journal › Article