Brain White mater imaging and cognitive ageing in the Lothian Birth Cohort of 1936:II

Project: Research

Deary, Ian (Principal Investigator)
Bastin, Mark (Co-investigator)
Penke, Lars (Co-investigator)
Starr, John (Co-investigator)
Wardlaw, Joanna (Co-investigator)

Status	Finished
Effective start/end date	8/06/11 → 7/03/15

Total award	£386,509.00
Funding organisation	MRC
Funder project reference	G1001245/96077

Total award	£421,715.00
Funding organisation	MRC
Funder project reference	G1001245/96077

Period	8/06/11 → 7/03/15

Project relations

Brain white matter imaging and cognitive ageing in the Lothian Birth Cohort of 1936
Project: Research

Activities

Healthy mental ageing in the Lothian Birth Cohorts od 1921 and 1936.
Activity: Other activity types › Types of Public engagement and outreach - Public lecture/debate/seminar
The Lothian Birth Cohort 1936.
Activity: Other activity types › Types of Public engagement and outreach - Public lecture/debate/seminar
The Lothian Birth Cohort 1936.
Activity: Other activity types › Types of Public engagement and outreach - Public lecture/debate/seminar
The Lothian Birth Cohort 1936 study.
Activity: Other activity types › Types of Public engagement and outreach - Public lecture/debate/seminar
The ups and downs of cognitive ageing in the Lothian Birth Cohorts of 1921 and 1936.
Activity: Academic talk or presentation types › Invited talk
Cognitive ageing and cognitive epidemiology in the Lothian Birth Cohorts of 1921 and 1936.
Activity: Academic talk or presentation types › Invited talk
Activity, engagement and cognitive ageing. Presentation in the symposium Genetic, brain imaging, biomarker and lifestyle effects on intelligence across the lifecourse: New results from the Lothian Birth Cohort 1936
Activity: Academic talk or presentation types › Invited talk
Healthy mental ageing: follow-up studies of the Lothian Birth Cohorts of 1921 and 1936.
Activity: Academic talk or presentation types › Invited talk

Research outputs

Alzheimer's disease susceptibility genes APOE and TOMM40, and brain white matter integrity in the Lothian Birth Cohort 1936
Research output: Contribution to journal › Article › peer-review
DNA methylation and the epigenetic clock in relation to physical frailty in older people: The Lothian Birth Cohort 1936
Research output: Contribution to journal › Article › peer-review
Machine learning of neuroimaging for assisted diagnosis of cognitive impairment and dementia: A systematic review
Research output: Contribution to journal › Review article › peer-review
Polygenic risk score for schizophrenia and structural brain connectivity in older age: A longitudinal connectome and tractography study
Research output: Contribution to journal › Article › peer-review
Personality, Health, and Brain Integrity: The Lothian Birth Cohort Study 1936
Research output: Contribution to journal › Article › peer-review
Brain white matter damage in aging and cognitive ability in youth and older age
Research output: Contribution to journal › Article › peer-review
Functional gene group analysis indicates no role for heterotrimeric g proteins in cognitive ability
Research output: Contribution to journal › Article › peer-review
Differentiation of calcified regions and iron deposits in the ageing brain on conventional structural MR images: Calcium and Iron on Conventional MRI
Research output: Contribution to journal › Article › peer-review
Exploratory analysis of dietary intake and brain iron accumulation detected using magnetic resonance imaging in older individuals: the Lothian Birth Cohort 1936
Research output: Contribution to journal › Article › peer-review
Structure and correlates of cognitive aging in a narrow age cohort
Research output: Contribution to journal › Article › peer-review
Vascular risk factors, large-artery atheroma, and brain white matter hyperintensities
Research output: Contribution to journal › Article › peer-review
Estimated maximal and current brain volume predict cognitive ability in old age
Research output: Contribution to journal › Article › peer-review
Incidental Findings on Brain MR Imaging in Older Community-Dwelling Subjects Are Common but Serious Medical Consequences Are Rare: A Cohort Study
Research output: Contribution to journal › Article › peer-review
Influence of thickening of the inner skull table on intracranial volume measurement in older people
Research output: Contribution to journal › Article › peer-review
ADRB2, white matter integrity and cognitive ageing in the Lothian Birth Cohort 1936
Research output: Contribution to journal › Meeting abstract › peer-review
Color fusion of magnetic resonance images improves intracranial volume measurement in studies of aging
Research output: Contribution to journal › Article › peer-review
Brain Ageing, Cognition in Youth and Old Age, and Vascular Disease in the Lothian Birth Cohort 1936: Rationale, Design and Methodology of the Imaging Protocol
Research output: Contribution to journal › Article › peer-review
The genetic association between personality and major depression or bipolar disorder. A polygenic score analysis using genome-wide association data
Research output: Contribution to journal › Article › peer-review
Association Between Blood Pressure, Internal Carotid Artery Flow Parameters And Age-related White Matter Disease
Research output: Contribution to journal › Meeting abstract › peer-review
Morphologic, distributional, volumetric, and intensity characterization of periventricular hyperintensities
Research output: Contribution to journal › Article › peer-review
Neuroprotective lifestyles and the aging brain Activity, atrophy, and white matter integrity
Research output: Contribution to journal › Article › peer-review
Reliability of two techniques for assessing cerebral iron deposits with structural magnetic resonance imaging
Research output: Contribution to journal › Article › peer-review
Compensation or inhibitory failure? Testing hypotheses of age-related right frontal lobe involvement in verbal memory ability using structural and diffusion MRI
Research output: Contribution to journal › Article › peer-review
A genome-wide search for genetic influences and biological pathways related to the brain's white matter integrity
Research output: Contribution to journal › Article › peer-review
A systematic review of brain frontal lobe parcellation techniques in magnetic resonance imaging
Research output: Contribution to journal › Article › peer-review
Close Correlation between Quantitative and Qualitative Assessments of White Matter Lesions
Research output: Contribution to journal › Article › peer-review
Towards the automatic computational assessment of enlarged perivascular spaces on brain magnetic resonance images: A systematic review
Research output: Contribution to journal › Literature review › peer-review
What factors contribute to successful cognitive ageing?
Research output: Contribution to journal › Meeting abstract › peer-review
Studying lifetime cognitive ageing in the Lothian Birth Cohorts of 1921 and 1936
Research output: Contribution to journal › Meeting abstract › peer-review
'On the street where you live': Neighbourhood deprivation and quality of life among community-dwelling older people in Edinburgh, Scotland
Research output: Contribution to journal › Article › peer-review
Design and validation of a novel method to measure cross-sectional area of neck muscles included during routine MR brain volume imaging
Research output: Contribution to journal › Article › peer-review
Identification of common variants associated with human hippocampal and intracranial volumes
Research output: Contribution to journal › Article › peer-review
Correlational structure of ‘frontal’ tests and intelligence tests indicates two components with asymmetrical neurostructural correlates in old age
Research output: Contribution to journal › Article › peer-review
The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data
Research output: Contribution to journal › Article › peer-review
Brain white matter integrity and cortisol in older men: the Lothian Birth Cohort 1936
Research output: Contribution to journal › Article › peer-review
White matter hyperintensities and normal-appearing white matter integrity in the ageing brain
Research output: Contribution to journal › Article › peer-review
Alzheimer's Disease susceptibility genes APOE and TOMM40, and hippocampal volumes in the Lothian birth cohort 1936
Research output: Contribution to journal › Article › peer-review
Brain white matter tract integrity as a neural foundation for general intelligence
Research output: Contribution to journal › Article › peer-review
Brain-wide white matter tract integrity is associated with information processing speed and general intelligence
Research output: Contribution to journal › Editorial › peer-review
Potential effect of skull thickening on the associations between cognition and brain atrophy in ageing
Research output: Contribution to journal › Article › peer-review
Associations between level and change in physical function and brain volumes
Research output: Contribution to journal › Article › peer-review
The association between carotid atheroma and cerebral cortex structure at age 73
Research output: Contribution to journal › Article › peer-review
Characterization of multifocal T2*-weighted MRI hypointensities in the basal ganglia of elderly, community-dwelling subjects
Research output: Contribution to journal › Article › peer-review
Childhood cognitive ability accounts for associations between cognitive ability and brain cortical thickness in old age
Research output: Contribution to journal › Article › peer-review
Brain iron deposits are associated with general cognitive ability and cognitive aging
Research output: Contribution to journal › Article › peer-review
Automatic segmentation of brain white matter and white matter lesions in normal aging: comparison of five multispectral techniques
Research output: Contribution to journal › Article › peer-review
Comparative analysis of atlas-based and manual prefrontal brain parcellation in an ageing cohort
Research output: Contribution to conference › Poster › peer-review
Multi-site study of additive genetic effects on fractional anisotropy of cerebral white matter: Comparing meta and megaanalytical approaches for data pooling
Research output: Contribution to journal › Article › peer-review
Blood Pressure, Internal Carotid Artery Flow Parameters, and Age-Related White Matter Hyperintensities
Research output: Contribution to journal › Article › peer-review
Portraying the relationship between frontal lobe volumes and complex cognition: Different parcellation protocols paint very different pictures.
Research output: Contribution to conference › Poster › peer-review
Assessing the performance of atlas-based prefrontal brain parcellation in an aging cohort
Research output: Contribution to journal › Article › peer-review
Brain atrophy associations with white matter lesions in the ageing brain: the Lothian Birth Cohort 1936
Research output: Contribution to journal › Article › peer-review
Neuroticism, depressive symptoms and white-matter integrity in the Lothian Birth Cohort 1936
Research output: Contribution to journal › Article › peer-review
Circulating Inflammatory Markers Are Associated With Magnetic Resonance Imaging-Visible Perivascular Spaces But Not Directly With White Matter Hyperintensities
Research output: Contribution to journal › Article › peer-review
Quantitative multi-modal MRI of the hippocampus and cognitive ability in community-dwelling older subjects
Research output: Contribution to journal › Article › peer-review
Whole genome association scan for genetic polymorphisms influencing information processing speed
Research output: Contribution to journal › Article › peer-review
Are APOE ɛ genotype and TOMM40 poly-T repeat length associations with cognitive ageing mediated by brain white matter tract integrity?
Research output: Contribution to journal › Article › peer-review
Automated segmentation of multifocal basal ganglia T2*-weighted MRI hypointensities
Research output: Contribution to journal › Article › peer-review
Gliovascular disruption and cognitive deficits in a mouse model with features of small vessel disease
Research output: Contribution to journal › Article › peer-review
Cerebral perivascular spaces visible on magnetic resonance imaging: Development of a qualitative rating scale and its observer reliability
Research output: Contribution to journal › Article › peer-review
Does white matter structure or hippocampal volume mediate associations between cortisol and cognitive ageing?
Research output: Contribution to journal › Article › peer-review
Brain iron deposits and lifespan cognitive ability
Research output: Contribution to journal › Article › peer-review
Intelligence in childhood and atherosclerosis of the carotid and peripheral arteries in later life: The Lothian Birth Cohort 1936
Research output: Contribution to journal › Article › peer-review
Genome-wide Studies of Verbal Declarative Memory in Nondemented Older People: The Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium
Research output: Contribution to journal › Article › peer-review
Volumetric and correlational implications of brain parcellation method selection: a 3-way comparison in the frontal lobes.
Research output: Contribution to journal › Article › peer-review
Brain volumetric changes and cognitive ageing during the eighth decade of life
Research output: Contribution to journal › Article › peer-review
Brain white matter structure and information processing speed in healthy older age
Research output: Contribution to journal › Article › peer-review
Structural brain MRI trait polygenic score prediction of cognitive abilities
Research output: Contribution to journal › Article › peer-review
Development and initial evaluation of a semi-automatic approach to assess perivascular spaces on conventional magnetic resonance images
Research output: Contribution to journal › Article › peer-review
Proton spectroscopic imaging of brain metabolites in basal ganglia of healthy older adults
Research output: Contribution to journal › Article › peer-review
APOE/TOMM40 genetic loci, white matter hyperintensities and cerebral microbleeds
Research output: Contribution to journal › Article › peer-review
Total MRI load of cerebral small vessel disease and cognitive ability in older people
Research output: Contribution to journal › Article › peer-review
Coupled changes in brain white matter microstructure and fluid intelligence in later life
Research output: Contribution to journal › Article › peer-review
Post-mortem brain analyses of the Lothian Birth Cohort 1936: Extending lifetime cognitive and brain phenotyping to the level of the synapse
Research output: Contribution to journal › Article › peer-review
Multi-Ethnic Genome-Wide Association Study of Cerebral White Matter Hyperintensities on MRI
Research output: Contribution to journal › Article › peer-review
Neural correlates of Trail Making Test performance in older adults: the Lothian Birth Cohort 1936
Research output: Contribution to conference › Poster › peer-review
Is education associated with improvements in general cognitive ability, or in specific skills?
Research output: Contribution to journal › Article › peer-review
Common genetic variants influence human subcortical brain structures
Research output: Contribution to journal › Letter › peer-review
Heritability of fractional anisotropy in human white matter: A comparison of Human Connectome Project and ENIGMA-DTI data
Research output: Contribution to journal › Article › peer-review
A comparison of location of acute symptomatic versus 'silent' small vessel lesions
Research output: Contribution to journal › Article › peer-review
Genes from a translational analysis support a multifactorial nature of white matter hyperintensities
Research output: Contribution to journal › Article › peer-review
Genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume
Research output: Contribution to journal › Article › peer-review
Association of allostatic load with brain structure and cognitive ability in later life
Research output: Contribution to journal › Article › peer-review
Cigarette smoking and thinning of the brain's cortex
Research output: Contribution to journal › Article › peer-review
Progression of white matter disease and cortical thinning are not related in older community-dwelling subjects
Research output: Contribution to journal › Article › peer-review
Systems genetics identifies a convergent gene network for cognition and neurodevelopmental disease
Research output: Contribution to journal › Article › peer-review
3D shape analysis of the brain's third ventricle using a midplane encoded symmetric template model
Research output: Contribution to journal › Article › peer-review
Longitudinal telomere length shortening and cognitive and physical decline in later life: The Lothian Birth Cohorts 1936 and 1921
Research output: Contribution to journal › Article › peer-review
Do white matter hyperintensities mediate the association between brain iron deposition and cognitive abilities in older people?
Research output: Contribution to journal › Article › peer-review
Vascular risk factors and progression of white matter hyperintensities in the Lothian Birth Cohort 1936
Research output: Contribution to journal › Article › peer-review
Associations between education and brain structure at age 73 years, adjusted for age 11 IQ
Research output: Contribution to journal › Article › peer-review
Getting Spearman off the skyhook: One more in a century (since Thomson, 1916) of attempts to vanquish g
Research output: Contribution to journal › Article › peer-review
ENIGMA and the individual: Predicting factors that affect the brain in 35 countries worldwide
Research output: Contribution to journal › Article › peer-review
William M. Feinberg Award for Excellence in Clinical Stroke: Small Vessel Disease; a Big Problem, But Fixable
Research output: Contribution to journal › Article › peer-review
Early life characteristics and late life burden of cerebral small vessel disease in the Lothian Birth Cohort 1936
Research output: Contribution to journal › Article › peer-review
Trait Conscientiousness and the Personality Meta-Trait Stability are Associated with Regional White Matter Microstructure
Research output: Contribution to journal › Article › peer-review
Interaction of APOE e4 and poor glycemic control predicts white matter hyperintensity growth from 73-76
Research output: Contribution to journal › Article › peer-review
Brain Lesion Segmentation through Image Synthesis and Outlier Detection
Research output: Contribution to journal › Article › peer-review
Associations between hippocampal morphology, diffusion characteristics, and salivary cortisol in older men
Research output: Contribution to journal › Article › peer-review
The influence of neighbourhoods and the social environment on sedentary behaviour in older adults in three prospective cohorts
Research output: Contribution to journal › Special issue › peer-review
Sleep and cognitive aging in the eighth decade of life
Research output: Contribution to journal › Article › peer-review
Brain cortical characteristics of lifetime cognitive ageing
Research output: Contribution to journal › Article › peer-review
Processing speed and the relationship between Trail Making Test-B performance, cortical thinning and white matter microstructure in older adults
Research output: Contribution to journal › Article › peer-review
Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney
Research output: Contribution to journal › Article › peer-review
Metric to quantify white matter damage on brain magnetic resonance images
Research output: Contribution to journal › Article › peer-review
Cognitive abilities, brain white matter hyperintensity volume and structural network connectivity in older age.
Research output: Contribution to journal › Article › peer-review
Cognitive ability does not predict objectively measured sedentary behaviour: Evidence from three older cohorts
Research output: Contribution to journal › Article › peer-review
Brain age predicts mortality
Research output: Contribution to journal › Article › peer-review
Coupled changes in hippocampal structure and cognitive ability in later life
Research output: Contribution to journal › Article › peer-review
Brain structural differences between 73- and 92-year olds matched for childhood intelligence, social background, and intracranial volume
Research output: Contribution to journal › Article › peer-review
Meta-analysis of epigenome-wide association studies of cognitive abilities
Research output: Contribution to journal › Article › peer-review
The epigenetic clock and objectively measured sedentary and walking behaviour in older adults: The Lothian Birth Cohort 1936
Research output: Contribution to journal › Article › peer-review
Risk and protective factors for structural brain ageing in the eighth decade of life
Research output: Contribution to journal › Article › peer-review
Brain grey and white matter predictors of verbal ability traits in older age: The Lothian Birth Cohort 1936
Research output: Contribution to journal › Article › peer-review
Dietary iodine exposure and brain structures and cognition in older people. Exploratory analysis in the Lothian Birth Cohort 1936
Research output: Contribution to journal › Article › peer-review
Large-scale cognitive GWAS meta-analysis reveals tissue-specific neural expression and potential nootropic drug targets
Research output: Contribution to journal › Article › peer-review
Integrative analysis of omics summary data reveals putative mechanisms underlying complex traits
Research output: Contribution to journal › Article › peer-review
What do older people do when sitting and why? Implications for decreasing sedentary behavior
Research output: Contribution to journal › Article › peer-review
Cognitive ability does not predict objectively measured sedentary behaviour: Evidence from three older cohorts
Research output: Contribution to journal › Article › peer-review
Apolipoprotein E genotype does not moderate the associations of depressive symptoms, neuroticism and allostatic load with cognitive ability and cognitive aging in the Lothian Birth Cohort 1936
Research output: Contribution to journal › Article › peer-review
Systematic comparative validation of self-report measures of sedentary time against an objective measure of postural sitting (activPAL)
Research output: Contribution to journal › Article › peer-review
Cognitive function in early and later life is associated with blood glucose in older individuals: Analysis of the Lothian Birth Cohort of 1936
Research output: Contribution to journal › Article › peer-review
The influence of dyslexia candidate genes on reading skill in old age
Research output: Contribution to journal › Article › peer-review
Positive and negative well-being and objectively measured sedentary behaviour in older adults: Evidence from three cohorts
Research output: Contribution to journal › Article › peer-review
Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting
Research output: Contribution to journal › Article › peer-review
Association between APOE e4 and white matter hyperintensity volume, but not total brain volume or white matter integrity
Research output: Contribution to journal › Article › peer-review
Association of apolipoprotein E with intracerebral hemorrhage risk by race/ethnicity: A meta-analysis
Research output: Contribution to journal › Article › peer-review
GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes
Research output: Contribution to journal › Article › peer-review
Identification of the presence of ischaemic stroke lesions by means of texture analysis on brain magnetic resonance images
Research output: Contribution to journal › Article › peer-review
Retinal microvasculature and cerebral small vessel disease in the Lothian Birth Cohort 1936 and Mild Stroke Study
Research output: Contribution to journal › Article › peer-review
Corticosteroids and regional variations in thickness of the human cerebral cortex across the lifespan
Research output: Contribution to journal › Article › peer-review
Perivascular spaces in the centrum semiovale at the beginning of the 8th decade of life: Effect on cognition and associations with mineral deposition
Research output: Contribution to journal › Article › peer-review
Spatial Gradient of Microstructural Changes in Normal-Appearing White Matter in Tracts Affected by White Matter Hyperintensities in Older Age
Research output: Contribution to journal › Article › peer-review
An epigenetic predictor of death captures multi-modal measures of brain health
Research output: Contribution to journal › Article › peer-review
Epigenetic signatures of smoking associate with cognitive function, brain structure, and mental and physical health outcomes in the Lothian Birth Cohort 1936
Research output: Contribution to journal › Article › peer-review
Physical frailty and decline in general and specific cognitive abilities: The Lothian Birth Cohort 1936
Research output: Contribution to journal › Article › peer-review
Brain peak width of skeletonised mean diffusivity (PSMD) and cognitive function in later life
Research output: Contribution to journal › Article › peer-review
Structural brain imaging correlates of general intelligence in UK Biobank
Research output: Contribution to journal › Article › peer-review
The genetic architecture of the human cerebral cortex
Research output: Contribution to journal › Article › peer-review
Computational quantification of brain perivascular space morphologies: Associations with vascular risk factors and white matter hyperintensities. A study in the Lothian Birth Cohort 1936
Research output: Contribution to journal › Article › peer-review
Fluctuating asymmetry in brain structure and general intelligence in 73-Year-olds
Research output: Contribution to journal › Article › peer-review
Genetic architecture of subcortical brain structures in 38,851 individuals
Research output: Contribution to journal › Article › peer-review
Epigenome-wide meta-analyses of blood DNA methylation and its association with subcortical volumes: Findings from the ENIGMA Epigenetics Working Group
Research output: Contribution to journal › Article › peer-review
Neurology-related protein biomarkers are associated with cognitive ability and brain volume in older age
Research output: Contribution to journal › Article › peer-review
Sleep and brain morphological changes in the eighth decade of life
Research output: Contribution to journal › Article › peer-review
Global and regional development of the human cerebral cortex: Molecular architecture and occupational aptitudes
Research output: Contribution to journal › Article › peer-review
Aging-sensitive networks within the human structural connectome are implicated in late-life cognitive declines.
Research output: Contribution to journal › Article › peer-review
Inflammation as a risk factor for the development of frailty in the Lothian Birth Cohort 1936
Research output: Contribution to journal › Article › peer-review
Adherence to the MIND diet is associated with 12-year all-cause mortality in older adults
Research output: Contribution to journal › Article › peer-review
Age-Related Changes of Peak Width Skeletonized Mean Diffusivity (PSMD) Across the Adult Lifespan: A Multi-Cohort Study
Research output: Contribution to journal › Article › peer-review
Common Genetic Variation Indicates Separate Causes for Periventricular and Deep White Matter Hyperintensities
Research output: Contribution to journal › Article › peer-review