Project relations

• Brain white matter imaging and cognitive ageing in the Lothian Birth Cohort of 1936

  Project: Research

Activities

• Healthy mental ageing in the Lothian Birth Cohorts od 1921 and 1936.

  Activity: Other activity types › Types of Public engagement and outreach - Public lecture/debate/seminar

• The Lothian Birth Cohort 1936.

  Activity: Other activity types › Types of Public engagement and outreach - Public lecture/debate/seminar

• The Lothian Birth Cohort 1936.

  Activity: Other activity types › Types of Public engagement and outreach - Public lecture/debate/seminar

• The Lothian Birth Cohort 1936 study.

  Activity: Other activity types › Types of Public engagement and outreach - Public lecture/debate/seminar

• The ups and downs of cognitive ageing in the Lothian Birth Cohorts of 1921 and 1936.

  Activity: Academic talk or presentation types › Invited talk

• Cognitive ageing and cognitive epidemiology in the Lothian Birth Cohorts of 1921 and 1936.

  Activity: Academic talk or presentation types › Invited talk

• Activity, engagement and cognitive ageing. Presentation in the symposium Genetic, brain imaging, biomarker and lifestyle effects on intelligence across the lifecourse: New results from the Lothian Birth Cohort 1936

  Activity: Academic talk or presentation types › Invited talk

• Healthy mental ageing: follow-up studies of the Lothian Birth Cohorts of 1921 and 1936.

  Activity: Academic talk or presentation types › Invited talk

Research outputs

• Alzheimer's disease susceptibility genes APOE and TOMM40, and brain white matter integrity in the Lothian Birth Cohort 1936

  Research output: Contribution to journal › Article

• DNA methylation and the epigenetic clock in relation to physical frailty in older people: The Lothian Birth Cohort 1936

  Research output: Contribution to journal › Article

• Machine learning of neuroimaging for assisted diagnosis of cognitive impairment and dementia: A systematic review

  Research output: Contribution to journal › Review article

• Polygenic risk score for schizophrenia and structural brain connectivity in older age: A longitudinal connectome and tractography study

  Research output: Contribution to journal › Article

• Personality, Health, and Brain Integrity: The Lothian Birth Cohort Study 1936

  Research output: Contribution to journal › Article

• Brain white matter damage in aging and cognitive ability in youth and older age

  Research output: Contribution to journal › Article

• Functional gene group analysis indicates no role for heterotrimeric g proteins in cognitive ability

  Research output: Contribution to journal › Article

• Differentiation of calcified regions and iron deposits in the ageing brain on conventional structural MR images: Calcium and Iron on Conventional MRI

  Research output: Contribution to journal › Article

• Exploratory analysis of dietary intake and brain iron accumulation detected using magnetic resonance imaging in older individuals: the Lothian Birth Cohort 1936

  Research output: Contribution to journal › Article

• Structure and correlates of cognitive aging in a narrow age cohort

  Research output: Contribution to journal › Article

• Vascular risk factors, large-artery atheroma, and brain white matter hyperintensities

  Research output: Contribution to journal › Article

• Estimated maximal and current brain volume predict cognitive ability in old age

  Research output: Contribution to journal › Article

• Incidental Findings on Brain MR Imaging in Older Community-Dwelling Subjects Are Common but Serious Medical Consequences Are Rare: A Cohort Study

  Research output: Contribution to journal › Article

• Influence of thickening of the inner skull table on intracranial volume measurement in older people

  Research output: Contribution to journal › Article

• ADRB2, white matter integrity and cognitive ageing in the Lothian Birth Cohort 1936

  Research output: Contribution to journal › Meeting abstract

• Color fusion of magnetic resonance images improves intracranial volume measurement in studies of aging

  Research output: Contribution to journal › Article

• Brain Ageing, Cognition in Youth and Old Age, and Vascular Disease in the Lothian Birth Cohort 1936: Rationale, Design and Methodology of the Imaging Protocol

  Research output: Contribution to journal › Article

• The genetic association between personality and major depression or bipolar disorder. A polygenic score analysis using genome-wide association data

  Research output: Contribution to journal › Article

• Association Between Blood Pressure, Internal Carotid Artery Flow Parameters And Age-related White Matter Disease

  Research output: Contribution to journal › Meeting abstract

• Morphologic, distributional, volumetric, and intensity characterization of periventricular hyperintensities

  Research output: Contribution to journal › Article

• Neuroprotective lifestyles and the aging brain Activity, atrophy, and white matter integrity

  Research output: Contribution to journal › Article

• Reliability of two techniques for assessing cerebral iron deposits with structural magnetic resonance imaging

  Research output: Contribution to journal › Article

• Compensation or inhibitory failure? Testing hypotheses of age-related right frontal lobe involvement in verbal memory ability using structural and diffusion MRI

  Research output: Contribution to journal › Article

• A genome-wide search for genetic influences and biological pathways related to the brain's white matter integrity

  Research output: Contribution to journal › Article

• A systematic review of brain frontal lobe parcellation techniques in magnetic resonance imaging

  Research output: Contribution to journal › Article

• Close Correlation between Quantitative and Qualitative Assessments of White Matter Lesions

  Research output: Contribution to journal › Article

• Towards the automatic computational assessment of enlarged perivascular spaces on brain magnetic resonance images: A systematic review

  Research output: Contribution to journal › Literature review

• What factors contribute to successful cognitive ageing?

  Research output: Contribution to journal › Meeting abstract

• Studying lifetime cognitive ageing in the Lothian Birth Cohorts of 1921 and 1936

  Research output: Contribution to journal › Meeting abstract

• 'On the street where you live': Neighbourhood deprivation and quality of life among community-dwelling older people in Edinburgh, Scotland

  Research output: Contribution to journal › Article

• Design and validation of a novel method to measure cross-sectional area of neck muscles included during routine MR brain volume imaging

  Research output: Contribution to journal › Article

• Identification of common variants associated with human hippocampal and intracranial volumes

  Research output: Contribution to journal › Article

• Correlational structure of ‘frontal’ tests and intelligence tests indicates two components with asymmetrical neurostructural correlates in old age

  Research output: Contribution to journal › Article

• The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data

  Research output: Contribution to journal › Article

• Brain white matter integrity and cortisol in older men: the Lothian Birth Cohort 1936

  Research output: Contribution to journal › Article

• White matter hyperintensities and normal-appearing white matter integrity in the ageing brain

  Research output: Contribution to journal › Article

• Alzheimer's Disease susceptibility genes APOE and TOMM40, and hippocampal volumes in the Lothian birth cohort 1936

  Research output: Contribution to journal › Article

• Brain white matter tract integrity as a neural foundation for general intelligence

  Research output: Contribution to journal › Article

• Brain-wide white matter tract integrity is associated with information processing speed and general intelligence

  Research output: Contribution to journal › Editorial

• Potential effect of skull thickening on the associations between cognition and brain atrophy in ageing

  Research output: Contribution to journal › Article

• Associations between level and change in physical function and brain volumes

  Research output: Contribution to journal › Article

• The association between carotid atheroma and cerebral cortex structure at age 73

  Research output: Contribution to journal › Article

• Characterization of multifocal T2*-weighted MRI hypointensities in the basal ganglia of elderly, community-dwelling subjects

  Research output: Contribution to journal › Article

• Childhood cognitive ability accounts for associations between cognitive ability and brain cortical thickness in old age

  Research output: Contribution to journal › Article

• Brain iron deposits are associated with general cognitive ability and cognitive aging

  Research output: Contribution to journal › Article

• Automatic segmentation of brain white matter and white matter lesions in normal aging: comparison of five multispectral techniques

  Research output: Contribution to journal › Article

• Comparative analysis of atlas-based and manual prefrontal brain parcellation in an ageing cohort

  Research output: Contribution to conference › Poster

• Multi-site study of additive genetic effects on fractional anisotropy of cerebral white matter: Comparing meta and megaanalytical approaches for data pooling

  Research output: Contribution to journal › Article

• Blood Pressure, Internal Carotid Artery Flow Parameters, and Age-Related White Matter Hyperintensities

  Research output: Contribution to journal › Article

• Portraying the relationship between frontal lobe volumes and complex cognition: Different parcellation protocols paint very different pictures.

  Research output: Contribution to conference › Poster

• Assessing the performance of atlas-based prefrontal brain parcellation in an aging cohort

  Research output: Contribution to journal › Article

• Brain atrophy associations with white matter lesions in the ageing brain: the Lothian Birth Cohort 1936

  Research output: Contribution to journal › Article

• Neuroticism, depressive symptoms and white-matter integrity in the Lothian Birth Cohort 1936

  Research output: Contribution to journal › Article

• Circulating Inflammatory Markers Are Associated With Magnetic Resonance Imaging-Visible Perivascular Spaces But Not Directly With White Matter Hyperintensities

  Research output: Contribution to journal › Article

• Quantitative multi-modal MRI of the hippocampus and cognitive ability in community-dwelling older subjects

  Research output: Contribution to journal › Article

• Whole genome association scan for genetic polymorphisms influencing information processing speed

  Research output: Contribution to journal › Article

• Are APOE ɛ genotype and TOMM40 poly-T repeat length associations with cognitive ageing mediated by brain white matter tract integrity?

  Research output: Contribution to journal › Article

• Automated segmentation of multifocal basal ganglia T2*-weighted MRI hypointensities

  Research output: Contribution to journal › Article

• Gliovascular disruption and cognitive deficits in a mouse model with features of small vessel disease

  Research output: Contribution to journal › Article

• Cerebral perivascular spaces visible on magnetic resonance imaging: Development of a qualitative rating scale and its observer reliability

  Research output: Contribution to journal › Article

• Does white matter structure or hippocampal volume mediate associations between cortisol and cognitive ageing?

  Research output: Contribution to journal › Article

• Brain iron deposits and lifespan cognitive ability

  Research output: Contribution to journal › Article

• Intelligence in childhood and atherosclerosis of the carotid and peripheral arteries in later life: The Lothian Birth Cohort 1936

  Research output: Contribution to journal › Article

• Genome-wide Studies of Verbal Declarative Memory in Nondemented Older People: The Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium

  Research output: Contribution to journal › Article

• Volumetric and correlational implications of brain parcellation method selection: a 3-way comparison in the frontal lobes.

  Research output: Contribution to journal › Article

• Brain volumetric changes and cognitive ageing during the eighth decade of life

  Research output: Contribution to journal › Article

• Brain white matter structure and information processing speed in healthy older age

  Research output: Contribution to journal › Article

• Structural brain MRI trait polygenic score prediction of cognitive abilities

  Research output: Contribution to journal › Article

• Development and initial evaluation of a semi-automatic approach to assess perivascular spaces on conventional magnetic resonance images

  Research output: Contribution to journal › Article

• Proton spectroscopic imaging of brain metabolites in basal ganglia of healthy older adults

  Research output: Contribution to journal › Article

• APOE/TOMM40 genetic loci, white matter hyperintensities and cerebral microbleeds

  Research output: Contribution to journal › Article

• Total MRI load of cerebral small vessel disease and cognitive ability in older people

  Research output: Contribution to journal › Article

• Coupled changes in brain white matter microstructure and fluid intelligence in later life

  Research output: Contribution to journal › Article

• Post-mortem brain analyses of the Lothian Birth Cohort 1936: Extending lifetime cognitive and brain phenotyping to the level of the synapse

  Research output: Contribution to journal › Article

• Multi-Ethnic Genome-Wide Association Study of Cerebral White Matter Hyperintensities on MRI

  Research output: Contribution to journal › Article

• Neural correlates of Trail Making Test performance in older adults: the Lothian Birth Cohort 1936

  Research output: Contribution to conference › Poster

• Is education associated with improvements in general cognitive ability, or in specific skills?

  Research output: Contribution to journal › Article

• Common genetic variants influence human subcortical brain structures

  Research output: Contribution to journal › Letter

• Heritability of fractional anisotropy in human white matter: A comparison of Human Connectome Project and ENIGMA-DTI data

  Research output: Contribution to journal › Article

• A comparison of location of acute symptomatic versus 'silent' small vessel lesions

  Research output: Contribution to journal › Article

• Genes from a translational analysis support a multifactorial nature of white matter hyperintensities

  Research output: Contribution to journal › Article

• Genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume

  Research output: Contribution to journal › Article

• Association of allostatic load with brain structure and cognitive ability in later life

  Research output: Contribution to journal › Article

• Cigarette smoking and thinning of the brain's cortex

  Research output: Contribution to journal › Article

• Progression of white matter disease and cortical thinning are not related in older community-dwelling subjects

  Research output: Contribution to journal › Article

• Systems genetics identifies a convergent gene network for cognition and neurodevelopmental disease

  Research output: Contribution to journal › Article

• 3D shape analysis of the brain's third ventricle using a midplane encoded symmetric template model

  Research output: Contribution to journal › Article

• Longitudinal telomere length shortening and cognitive and physical decline in later life: The Lothian Birth Cohorts 1936 and 1921

  Research output: Contribution to journal › Article

• Do white matter hyperintensities mediate the association between brain iron deposition and cognitive abilities in older people?

  Research output: Contribution to journal › Article

• Vascular risk factors and progression of white matter hyperintensities in the Lothian Birth Cohort 1936

  Research output: Contribution to journal › Article

• Associations between education and brain structure at age 73 years, adjusted for age 11 IQ

  Research output: Contribution to journal › Article

• Getting Spearman off the skyhook: One more in a century (since Thomson, 1916) of attempts to vanquish g

  Research output: Contribution to journal › Article

• ENIGMA and the individual: Predicting factors that affect the brain in 35 countries worldwide

  Research output: Contribution to journal › Article

• William M. Feinberg Award for Excellence in Clinical Stroke: Small Vessel Disease; a Big Problem, But Fixable

  Research output: Contribution to journal › Article

• Early life characteristics and late life burden of cerebral small vessel disease in the Lothian Birth Cohort 1936

  Research output: Contribution to journal › Article

• Trait Conscientiousness and the Personality Meta-Trait Stability are Associated with Regional White Matter Microstructure

  Research output: Contribution to journal › Article

• Interaction of APOE e4 and poor glycemic control predicts white matter hyperintensity growth from 73-76

  Research output: Contribution to journal › Article

• Brain Lesion Segmentation through Image Synthesis and Outlier Detection

  Research output: Contribution to journal › Article

• Associations between hippocampal morphology, diffusion characteristics, and salivary cortisol in older men

  Research output: Contribution to journal › Article

• The influence of neighbourhoods and the social environment on sedentary behaviour in older adults in three prospective cohorts

  Research output: Contribution to journal › Special issue

• Sleep and cognitive aging in the eighth decade of life

  Research output: Contribution to journal › Article

• Brain cortical characteristics of lifetime cognitive ageing

  Research output: Contribution to journal › Article

• Processing speed and the relationship between Trail Making Test-B performance, cortical thinning and white matter microstructure in older adults

  Research output: Contribution to journal › Article

• Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney

  Research output: Contribution to journal › Article

• Metric to quantify white matter damage on brain magnetic resonance images

  Research output: Contribution to journal › Article

• Cognitive abilities, brain white matter hyperintensity volume and structural network connectivity in older age.

  Research output: Contribution to journal › Article

• Cognitive ability does not predict objectively measured sedentary behaviour: Evidence from three older cohorts

  Research output: Contribution to journal › Article

• Brain age predicts mortality

  Research output: Contribution to journal › Article

• Coupled changes in hippocampal structure and cognitive ability in later life

  Research output: Contribution to journal › Article

• Brain structural differences between 73- and 92-year olds matched for childhood intelligence, social background, and intracranial volume

  Research output: Contribution to journal › Article

• Meta-analysis of epigenome-wide association studies of cognitive abilities

  Research output: Contribution to journal › Article

• The epigenetic clock and objectively measured sedentary and walking behaviour in older adults: The Lothian Birth Cohort 1936

  Research output: Contribution to journal › Article

• Risk and protective factors for structural brain ageing in the eighth decade of life

  Research output: Contribution to journal › Article

• Brain grey and white matter predictors of verbal ability traits in older age: The Lothian Birth Cohort 1936

  Research output: Contribution to journal › Article

• Dietary iodine exposure and brain structures and cognition in older people. Exploratory analysis in the Lothian Birth Cohort 1936

  Research output: Contribution to journal › Article

• Large-scale cognitive GWAS meta-analysis reveals tissue-specific neural expression and potential nootropic drug targets

  Research output: Contribution to journal › Article

• Integrative analysis of omics summary data reveals putative mechanisms underlying complex traits

  Research output: Contribution to journal › Article

• What Do Older People Do When Sitting and Why? Implications for Decreasing Sedentary Behavior

  Research output: Contribution to journal › Article

• Cognitive ability does not predict objectively measured sedentary behaviour: Evidence from three older cohorts

  Research output: Contribution to journal › Article

• Apolipoprotein E genotype does not moderate the associations of depressive symptoms, neuroticism and allostatic load with cognitive ability and cognitive aging in the Lothian Birth Cohort 1936

  Research output: Contribution to journal › Article

• Systematic comparative validation of self-report measures of sedentary time against an objective measure of postural sitting (activPAL)

  Research output: Contribution to journal › Article

• Cognitive function in early and later life is associated with blood glucose in older individuals: Analysis of the Lothian Birth Cohort of 1936

  Research output: Contribution to journal › Article

• The influence of dyslexia candidate genes on reading skill in old age

  Research output: Contribution to journal › Article

• Positive and negative well-being and objectively measured sedentary behaviour in older adults: Evidence from three cohorts

  Research output: Contribution to journal › Article

• Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting

  Research output: Contribution to journal › Article

• Association between APOE e4 and white matter hyperintensity volume, but not total brain volume or white matter integrity

  Research output: Contribution to journal › Article

• Association of apolipoprotein E with intracerebral hemorrhage risk by race/ethnicity: A meta-analysis

  Research output: Contribution to journal › Article

• GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes

  Research output: Contribution to journal › Article

• Identification of the presence of ischaemic stroke lesions by means of texture analysis on brain magnetic resonance images

  Research output: Contribution to journal › Article

• Retinal microvasculature and cerebral small vessel disease in the Lothian Birth Cohort 1936 and Mild Stroke Study

  Research output: Contribution to journal › Article

• Corticosteroids and regional variations in thickness of the human cerebral cortex across the lifespan

  Research output: Contribution to journal › Article

• Perivascular spaces in the centrum semiovale at the beginning of the 8th decade of life: Effect on cognition and associations with mineral deposition

  Research output: Contribution to journal › Article

• Spatial Gradient of Microstructural Changes in Normal-Appearing White Matter in Tracts Affected by White Matter Hyperintensities in Older Age

  Research output: Contribution to journal › Article

• An epigenetic predictor of death captures multi-modal measures of brain health

  Research output: Contribution to journal › Article

• Epigenetic signatures of smoking associate with cognitive function, brain structure, and mental and physical health outcomes in the Lothian Birth Cohort 1936

  Research output: Contribution to journal › Article

• Physical frailty and decline in general and specific cognitive abilities: The Lothian Birth Cohort 1936

  Research output: Contribution to journal › Article

• Brain peak width of skeletonised mean diffusivity (PSMD) and cognitive function in later life

  Research output: Contribution to journal › Article

• Structural brain imaging correlates of general intelligence in UK Biobank

  Research output: Contribution to journal › Article

• Computational quantification of brain perivascular space morphologies: Associations with vascular risk factors and white matter hyperintensities. A study in the Lothian Birth Cohort 1936

  Research output: Contribution to journal › Article

• Fluctuating asymmetry in brain structure and general intelligence in 73-Year-olds

  Research output: Contribution to journal › Article

• Genetic architecture of subcortical brain structures in 38,851 individuals

  Research output: Contribution to journal › Article

• Epigenome-wide meta-analyses of blood DNA methylation and its association with subcortical volumes: Findings from the ENIGMA Epigenetics Working Group

  Research output: Contribution to journal › Article

• Neurology-related protein biomarkers are associated with cognitive ability and brain volume in older age

  Research output: Contribution to journal › Article

• Sleep and brain morphological changes in the eighth decade of life

  Research output: Contribution to journal › Article