Determining the role of cxcr5-expressing dendritic cells in imune function and tse agent neuroinvasion from the intestine

Project: Research

Mabbott, Neil (Principal Investigator)

Status	Finished
Effective start/end date	1/05/09 → 30/09/12

Total award	£461,921.00
Funding organisation	BBSRC
Funder project reference	BB/F019726/1

Period	1/05/09 → 30/09/12

Key findings

We have successfully created a unique transgenic mouse line enabling the conditional ablation of the CXCR5 gene in macrophages and dendritic cells.

Project still in progress and findings will be published as soon as ready.

Press/Media

A case of classical BSE found on Aberdeenshire farm in 2018
Press/Media: Expert Comment

Research outputs

The role of CD11c+ cells in TSE agent neuroinvasion from the skin
Research output: Contribution to conference › Abstract
Defining the anatomical localisation of subsets of the murine mononuclear phagocyte system using integrin alpha X (Itgax, CD11c) and colony stimulating factor 1 receptor (Csf1r, CD115) expression fails to discriminate dendritic cells from macrophages
Research output: Contribution to journal › Article › peer-review
Meta-analysis of lineage-specific gene expression signatures in mouse leukocyte populations
Research output: Contribution to journal › Article › peer-review
Determining the role of mononuclear phagocytes in prion neuroinvasion from the skin
Research output: Contribution to journal › Article › peer-review
Determining the influence of the host immune system on TSE pathogenesis
Research output: Contribution to conference › Abstract
Prion pathogenesis and secondary lymphoid organs (SLO): Tracking the SLO spread of prions to the brain
Research output: Contribution to journal › Article › peer-review
The diverse roles of mononuclear phagocytes in prion disease pathogenesis
Research output: Contribution to journal › Article › peer-review
Involvement of skin DC subsets in TSE transmission
Research output: Contribution to conference › Abstract
Knockout of sialoadhesin enhances microglial accumulation during prion pathogenesis
Research output: Contribution to journal › Meeting abstract
Defining anatomical localisation and subsets of the murine mononuclear phagocyte system using integrin alpha X (ITGAX/CD11c) and colony stimulating factor 1 receptor (CSF1-R/CD115) expression fails to discriminate macrophages from dendritic cells
Research output: Contribution to conference › Poster
Pathway Analysis of Integrin Alpha X/Beta 2 (CD11c/CD18) in the Murine Mononuclear Phagocyte Lineage
Research output: Contribution to conference › Abstract
Can DCs be distinguished from macrophages by molecular signatures?
Research output: Contribution to journal › Letter › peer-review
Prion Disease and the Innate Immune System
Research output: Contribution to journal › Article › peer-review
CSF-1 receptor-mediated differentiation of a new type of monocytic cell with B cell-stimulating activity: its selective dependence on IL-34
Research output: Contribution to journal › Article › peer-review
Peripheral prion disease pathogenesis is unaltered in the absence of sialoadhesin (Siglec-1/CD169)
Research output: Contribution to journal › Article › peer-review
Human prion diseases and the risk of their transmission during anatomical dissection
Research output: Contribution to journal › Article › peer-review
Prospects for safe and effective vaccines against prion diseases
Research output: Contribution to journal › Editorial › peer-review
The good, the bad and the ugly of dendritic cells during prion disease
Research output: Contribution to journal › Literature review › peer-review
From scientific curiosity to public enemy number one in six short months
Research output: Contribution to journal › Article › peer-review
Prion pathogenesis is unaltered following down-regulation of SIGN-R1
Research output: Contribution to journal › Article › peer-review
Oral prion disease pathogenesis is impeded in the specific absence of CXCR5-expressing dendritic cells
Research output: Contribution to journal › Article › peer-review
Antigen presenting ILC3 regulate T cell-dependent IgA responses to colonic mucosal-associated bacteria
Research output: Contribution to journal › Article › peer-review
Type I interferon induces CXCL13 to support ectopic germinal center formation
Research output: Contribution to journal › Article › peer-review