Research outputs

• Induction of Eosinophil Apoptosis by the Cyclin-Dependent Kinase Inhibitor AT7519 Promotes the Resolution of Eosinophil-Dominant Allergic Inflammation

  Research output: Contribution to journal › Article

• Activation of conventional protein kinase C (PKC) is critical in the generation of human neutrophil extracellular traps

  Research output: Contribution to journal › Article

• Cyclin-dependent kinases 7 and 9 specifically regulate neutrophil transcription and their inhibition drives apoptosis to promote resolution of inflammation

  Research output: Contribution to journal › Article

• Flavones induce neutrophil apoptosis by down-regulation of Mcl-1 via a proteasomal-dependent pathway

  Research output: Contribution to journal › Article

• Downregulation of Mcl-1 has anti-inflammatory pro-resolution effects and enhances bacterial clearance from the lung

  Research output: Contribution to journal › Article

• Technical advance: autofluorescence-based sorting: rapid and nonperturbing isolation of ultrapure neutrophils to determine cytokine production

  Research output: Contribution to journal › Article

• Oxygen levels determine the ability of glucocorticoids to influence neutrophil survival in inflammatory environments

  Research output: Contribution to journal › Article

• Novel R-roscovitine NO-donor hybrid compounds as potential pro-resolution of inflammation agents

  Research output: Contribution to journal › Article

• The involvement of xanthohumol in the expression of annexin in human malignant glioblastoma cells

  Research output: Contribution to journal › Article

• Assessment of neutrophil apoptosis

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

• Apoptotic cell clearance: basic biology and therapeutic potential

  Research output: Contribution to journal › Literature review

• Leukocyte migratory responses to apoptosis: the attraction and the distraction

  Research output: Contribution to journal › Article

• 5α-reduced glucocorticoids exhibit dissociated anti-inflammatory and metabolic effects

  Research output: Contribution to journal › Article

• Xanthohumol induces apoptosis in human malignant glioblastoma cells by increasing reactive oxygen species and activating MAPK pathways

  Research output: Contribution to journal › Article

• Sildenafil reduces alcohol-induced gastric damage: just say 'NO'

  Research output: Contribution to journal › Editorial

• High-capacity hydrogen and nitric oxide adsorption and storage in a metal-organic framework

  Research output: Contribution to journal › Article

• A novel hybrid aspirin-NO-releasing compound inhibits TNFalpha release from LPS-activated human monocytes and macrophages

  Research output: Contribution to journal › Article

• C5a Mediates Peripheral Blood Neutrophil Dysfunction in Critically Ill Patients

  Research output: Contribution to journal › Article

• Secondary necrosis of apoptotic neutrophils induced by the human cathelicidin LL-37 is not proinflammatory to phagocytosing macrophages

  Research output: Contribution to journal › Article

• Cyclic GMP protects human macrophages against peroxynitrite-induced apoptosis

  Research output: Contribution to journal › Article

• Demonstration of a novel technique to quantitatively assess inflammatory mediators and cells in rat knee joints

  Research output: Contribution to journal › Article

• GEA 3162, a peroxynitrite donor, induces Bcl-2-sensitive, p53-independent apoptosis in murine bone marrow cells

  Research output: Contribution to journal › Article

• Editorial: Neutrophil apoptosis: hot on the TRAIL of inflammatory resolution

  Research output: Contribution to journal › Editorial

• The role of the purinergic P2X7 receptor in inflammation

  Research output: Contribution to journal › Article

• Differential susceptibility to nitric oxide-evoked apoptosis in human inflammatory cells

  Research output: Contribution to journal › Article

• Apoptotic human cells inhibit migration of granulocytes via release of lactoferrin

  Research output: Contribution to journal › Article

• Inhibition of eosinophil migration by lactoferrin

  Research output: Contribution to journal › Article

• Imaging inflammation: Molecular strategies to visualize key components of the inflammatory cascade, from initiation to resolution

  Research output: Contribution to journal › Literature review

• Modulation of granulocyte apoptosis can influence the resolution of inflammation

  Research output: Contribution to journal › Article

• Macrophage phagocytosis of apoptotic neutrophils is critically regulated by the opposing actions of pro-inflammatory and anti-inflammatory agents: key role for TNF-alpha

  Research output: Contribution to journal › Article

• Cyclic AMP enhances resolution of allergic pleurisy by promoting inflammatory cell apoptosis via inhibition of PI3K/Akt and NF-kappa B

  Research output: Contribution to journal › Article

• Highlights of a workshop to discuss targeting inflammation in cystic fibrosis

  Research output: Contribution to journal › Literature review

• PDE4 inhibition drives resolution of neutrophilic inflammation by inducing apoptosis in a PKA-PI3K/Akt-dependent and NF-kappaB-independent manner

  Research output: Contribution to journal › Article

• Cyclin-dependent kinase inhibitors enhance the resolution of inflammation by promoting inflammatory cell apoptosis

  Research output: Contribution to journal › Article

• Targeting V1A-vasopressin receptors with [Arg6, D-Trp7,9, NmePhe8]-substance P (6-11) identifies a strategy to develop novel anti-cancer therapies

  Research output: Contribution to journal › Article

• The CDK inhibitor, R-roscovitine, promotes eosinophil apoptosis by down-regulation of Mcl-1

  Research output: Contribution to journal › Article

• Analysis of neutrophil apoptosis

  Research output: Contribution to journal › Article

• Enzyme-Independent NO Stores in Human Skin: Quantification and Influence of UV Radiation

  Research output: Contribution to journal › Article

• Resolution of inflammation: state of the art, definitions and terms

  Research output: Contribution to journal › Article

• A novel subpopulation of monocyte-like cells in the human lung after LPS inhalation

  Research output: Contribution to journal › Article

• Characterization of the effects of cross-linking of macrophage CD44 associated with increased phagocytosis of apoptotic PMN

  Research output: Contribution to journal › Article

• Peritonitis Activates Transcription of the Human Prolactin Locus in Myeloid Cells in a Humanized Transgenic Rat Model

  Research output: Contribution to journal › Article

• NO-loaded Zn2+-exchanged zeolite materials: A potential bifunctional anti-bacterial strategy

  Research output: Contribution to journal › Article

• Mechanisms of Resolution of Inflammation A Focus on Cardiovascular Disease

  Research output: Contribution to journal › Article

• Anti-inflammatory mediators as physiological and pharmacological regulators of parturition

  Research output: Contribution to journal › Literature review

• The cyclin-dependent kinase inhibitor R-roscovitine down-regulates Mcl-1 to override pro-inflammatory signalling and drive neutrophil apoptosis

  Research output: Contribution to journal › Article

• C5a-mediated neutrophil dysfunction is RhoA-dependent and predicts infection in critically ill patients

  Research output: Contribution to journal › Article

• "Relevance of granulocyte apoptosis to resolution of inflammation at the respiratory mucosa"

  Research output: Contribution to journal › Literature review

• Cyclin-dependent kinase inhibitor drugs as potential novel anti-inflammatory and pro-resolution agents

  Research output: Contribution to journal › Literature review

• Monocytes Control Second-Phase Neutrophil Emigration in Established Lipopolysaccharide-induced Murine Lung Injury

  Research output: Contribution to journal › Article

• Topically Applied Nitric Oxide Induces T-Lymphocyte Infiltration in Human Skin, but Minimal Inflammation

  Research output: Contribution to journal › Article

• Clearance of dying cells and autoimmunity

  Research output: Contribution to journal › Article

• Phagocytosis of apoptotic cells

  Research output: Contribution to journal › Article

• Effects of glucocorticoids on apoptosis and clearance of apoptotic cells

  Research output: Contribution to journal › Article

• The anti-inflammatory effects and the inhibition of neutrophil responsiveness by Barleria lupulina and Clinacanthus nutans extracts

  Research output: Contribution to journal › Article

• Novel pharmacological strategies for driving inflammatory cell apoptosis and enhancing the resolution of inflammation

  Research output: Contribution to journal › Article

• Neutrophil Apoptosis: Relevance to the Innate Immune Response and Inflammatory Disease

  Research output: Contribution to journal › Literature review

• Invertebrate extracellular phagocyte traps show that chromatin is an ancient defence weapon

  Research output: Contribution to journal › Article

• Resolution of inflammation: Mechanisms and opportunity for drug development

  Research output: Contribution to journal › Literature review

• Galectin-3 reduces the severity of pneumococcal pneumonia by augmenting neutrophil function

  Research output: Contribution to journal › Article

• Prostaglandin F2alpha-F-prostanoid receptor signaling promotes neutrophil chemotaxis via chemokine (C-X-C motif) ligand 1 in endometrial adenocarcinoma

  Research output: Contribution to journal › Article

• Tissue- and stimulus-dependent role of phosphatidylinositol 3-kinase isoforms for neutrophil recruitment induced by chemoattractants in vivo

  Research output: Contribution to journal › Article

• Crosstalk between monocytes and myometrial smooth muscle in culture generates synergistic pro-inflammatory cytokine production and enhances myocyte contraction, with effects opposed by progesterone

  Research output: Contribution to journal › Article

• 11β-Hydroxysteroid Dehydrogenase type 1 is expressed in neutrophils and restrains an inflammatory response in male mice

  Research output: Contribution to journal › Article