Induction of neutrophil apoptosis and treatment of severe lung inflammation

Project: Research

Rossi, Adriano (Principal Investigator)

Status	Finished
Effective start/end date	1/09/07 → 29/02/12

Total award	£1,706,335.00
Funding organisation	MRC
Funder project reference	G0601481

Period	1/09/07 → 29/02/12

Research outputs

Induction of Eosinophil Apoptosis by the Cyclin-Dependent Kinase Inhibitor AT7519 Promotes the Resolution of Eosinophil-Dominant Allergic Inflammation
Research output: Contribution to journal › Article › peer-review
Activation of conventional protein kinase C (PKC) is critical in the generation of human neutrophil extracellular traps
Research output: Contribution to journal › Article › peer-review
Cyclin-dependent kinases 7 and 9 specifically regulate neutrophil transcription and their inhibition drives apoptosis to promote resolution of inflammation
Research output: Contribution to journal › Article › peer-review
Flavones induce neutrophil apoptosis by down-regulation of Mcl-1 via a proteasomal-dependent pathway
Research output: Contribution to journal › Article › peer-review
Downregulation of Mcl-1 has anti-inflammatory pro-resolution effects and enhances bacterial clearance from the lung
Research output: Contribution to journal › Article › peer-review
Technical advance: autofluorescence-based sorting: rapid and nonperturbing isolation of ultrapure neutrophils to determine cytokine production
Research output: Contribution to journal › Article › peer-review
Oxygen levels determine the ability of glucocorticoids to influence neutrophil survival in inflammatory environments
Research output: Contribution to journal › Article › peer-review
Novel R-roscovitine NO-donor hybrid compounds as potential pro-resolution of inflammation agents
Research output: Contribution to journal › Article › peer-review
The involvement of xanthohumol in the expression of annexin in human malignant glioblastoma cells
Research output: Contribution to journal › Article › peer-review
Assessment of neutrophil apoptosis
Research output: Chapter in Book/Report/Conference proceeding › Chapter
Apoptotic cell clearance: basic biology and therapeutic potential
Research output: Contribution to journal › Literature review › peer-review
Leukocyte migratory responses to apoptosis: the attraction and the distraction
Research output: Contribution to journal › Article › peer-review
5α-reduced glucocorticoids exhibit dissociated anti-inflammatory and metabolic effects
Research output: Contribution to journal › Article › peer-review
Xanthohumol induces apoptosis in human malignant glioblastoma cells by increasing reactive oxygen species and activating MAPK pathways
Research output: Contribution to journal › Article › peer-review
Sildenafil reduces alcohol-induced gastric damage: just say 'NO'
Research output: Contribution to journal › Editorial › peer-review
High-capacity hydrogen and nitric oxide adsorption and storage in a metal-organic framework
Research output: Contribution to journal › Article › peer-review
A novel hybrid aspirin-NO-releasing compound inhibits TNFalpha release from LPS-activated human monocytes and macrophages
Research output: Contribution to journal › Article › peer-review
C5a Mediates Peripheral Blood Neutrophil Dysfunction in Critically Ill Patients
Research output: Contribution to journal › Article › peer-review
Secondary necrosis of apoptotic neutrophils induced by the human cathelicidin LL-37 is not proinflammatory to phagocytosing macrophages
Research output: Contribution to journal › Article › peer-review
Cyclic GMP protects human macrophages against peroxynitrite-induced apoptosis
Research output: Contribution to journal › Article › peer-review
Demonstration of a novel technique to quantitatively assess inflammatory mediators and cells in rat knee joints
Research output: Contribution to journal › Article › peer-review
GEA 3162, a peroxynitrite donor, induces Bcl-2-sensitive, p53-independent apoptosis in murine bone marrow cells
Research output: Contribution to journal › Article › peer-review
Editorial: Neutrophil apoptosis: hot on the TRAIL of inflammatory resolution
Research output: Contribution to journal › Editorial › peer-review
The role of the purinergic P2X7 receptor in inflammation
Research output: Contribution to journal › Article › peer-review
Differential susceptibility to nitric oxide-evoked apoptosis in human inflammatory cells
Research output: Contribution to journal › Article › peer-review
Apoptotic human cells inhibit migration of granulocytes via release of lactoferrin
Research output: Contribution to journal › Article › peer-review
Inhibition of eosinophil migration by lactoferrin
Research output: Contribution to journal › Article › peer-review
Imaging inflammation: Molecular strategies to visualize key components of the inflammatory cascade, from initiation to resolution
Research output: Contribution to journal › Literature review › peer-review
Modulation of granulocyte apoptosis can influence the resolution of inflammation
Research output: Contribution to journal › Article › peer-review
Macrophage phagocytosis of apoptotic neutrophils is critically regulated by the opposing actions of pro-inflammatory and anti-inflammatory agents: key role for TNF-alpha
Research output: Contribution to journal › Article › peer-review
Cyclic AMP enhances resolution of allergic pleurisy by promoting inflammatory cell apoptosis via inhibition of PI3K/Akt and NF-kappa B
Research output: Contribution to journal › Article › peer-review
Highlights of a workshop to discuss targeting inflammation in cystic fibrosis
Research output: Contribution to journal › Literature review › peer-review
PDE4 inhibition drives resolution of neutrophilic inflammation by inducing apoptosis in a PKA-PI3K/Akt-dependent and NF-kappaB-independent manner
Research output: Contribution to journal › Article › peer-review
Cyclin-dependent kinase inhibitors enhance the resolution of inflammation by promoting inflammatory cell apoptosis
Research output: Contribution to journal › Article › peer-review
Targeting V1A-vasopressin receptors with [Arg6, D-Trp7,9, NmePhe8]-substance P (6-11) identifies a strategy to develop novel anti-cancer therapies
Research output: Contribution to journal › Article › peer-review
The CDK inhibitor, R-roscovitine, promotes eosinophil apoptosis by down-regulation of Mcl-1
Research output: Contribution to journal › Article › peer-review
Analysis of neutrophil apoptosis
Research output: Contribution to journal › Article › peer-review
Enzyme-Independent NO Stores in Human Skin: Quantification and Influence of UV Radiation
Research output: Contribution to journal › Article › peer-review
Resolution of inflammation: state of the art, definitions and terms
Research output: Contribution to journal › Article › peer-review
A novel subpopulation of monocyte-like cells in the human lung after LPS inhalation
Research output: Contribution to journal › Article › peer-review
Characterization of the effects of cross-linking of macrophage CD44 associated with increased phagocytosis of apoptotic PMN
Research output: Contribution to journal › Article › peer-review
Peritonitis Activates Transcription of the Human Prolactin Locus in Myeloid Cells in a Humanized Transgenic Rat Model
Research output: Contribution to journal › Article › peer-review
NO-loaded Zn2+-exchanged zeolite materials: A potential bifunctional anti-bacterial strategy
Research output: Contribution to journal › Article › peer-review
Mechanisms of Resolution of Inflammation A Focus on Cardiovascular Disease
Research output: Contribution to journal › Article › peer-review
Anti-inflammatory mediators as physiological and pharmacological regulators of parturition
Research output: Contribution to journal › Literature review › peer-review
The cyclin-dependent kinase inhibitor R-roscovitine down-regulates Mcl-1 to override pro-inflammatory signalling and drive neutrophil apoptosis
Research output: Contribution to journal › Article › peer-review
C5a-mediated neutrophil dysfunction is RhoA-dependent and predicts infection in critically ill patients
Research output: Contribution to journal › Article › peer-review
"Relevance of granulocyte apoptosis to resolution of inflammation at the respiratory mucosa"
Research output: Contribution to journal › Literature review › peer-review
Cyclin-dependent kinase inhibitor drugs as potential novel anti-inflammatory and pro-resolution agents
Research output: Contribution to journal › Literature review › peer-review
Monocytes Control Second-Phase Neutrophil Emigration in Established Lipopolysaccharide-induced Murine Lung Injury
Research output: Contribution to journal › Article › peer-review
Topically Applied Nitric Oxide Induces T-Lymphocyte Infiltration in Human Skin, but Minimal Inflammation
Research output: Contribution to journal › Article › peer-review
Clearance of dying cells and autoimmunity
Research output: Contribution to journal › Article › peer-review
Phagocytosis of apoptotic cells
Research output: Contribution to journal › Article › peer-review
Effects of glucocorticoids on apoptosis and clearance of apoptotic cells
Research output: Contribution to journal › Article › peer-review
The anti-inflammatory effects and the inhibition of neutrophil responsiveness by Barleria lupulina and Clinacanthus nutans extracts
Research output: Contribution to journal › Article › peer-review
Novel pharmacological strategies for driving inflammatory cell apoptosis and enhancing the resolution of inflammation
Research output: Contribution to journal › Article › peer-review
Neutrophil Apoptosis: Relevance to the Innate Immune Response and Inflammatory Disease
Research output: Contribution to journal › Literature review › peer-review
Invertebrate extracellular phagocyte traps show that chromatin is an ancient defence weapon
Research output: Contribution to journal › Article › peer-review
Resolution of inflammation: Mechanisms and opportunity for drug development
Research output: Contribution to journal › Literature review › peer-review
Galectin-3 reduces the severity of pneumococcal pneumonia by augmenting neutrophil function
Research output: Contribution to journal › Article › peer-review
Prostaglandin F2alpha-F-prostanoid receptor signaling promotes neutrophil chemotaxis via chemokine (C-X-C motif) ligand 1 in endometrial adenocarcinoma
Research output: Contribution to journal › Article › peer-review
Tissue- and stimulus-dependent role of phosphatidylinositol 3-kinase isoforms for neutrophil recruitment induced by chemoattractants in vivo
Research output: Contribution to journal › Article › peer-review
Crosstalk between monocytes and myometrial smooth muscle in culture generates synergistic pro-inflammatory cytokine production and enhances myocyte contraction, with effects opposed by progesterone
Research output: Contribution to journal › Article › peer-review
11β-Hydroxysteroid Dehydrogenase type 1 is expressed in neutrophils and restrains an inflammatory response in male mice
Research output: Contribution to journal › Article › peer-review