Edinburgh Research Explorer

Investigating the roles of follicular dendritic cells in TSE agent neuroinvasion from lymphoid tissues

Project: Research

StatusFinished
Effective start/end date1/05/0831/08/14
Total award£162,386.00
Funding organisationBBSRC
Funder project referenceBB/D00831X/3
Period1/05/0831/08/14

Key findings

-Demonstrated for the first time that follicular dendritic cells alone are the important sites of TSE agent accumulation in lymphoid tissues.



-Demonstrated for the first time that the specific ablation of PrPC expression only on FDC blocked TSE agent accumulation in lymphoid tissues and subsequent neuroinvasion.

Press/Media

Research outputs