Mediators of regulation and immunity in helminth infections - Edinburgh Research Explorer

Edinburgh Research Explorer

Mediators of regulation and immunity in helminth infections

Project: Research

Maizels, Rick (Principal Investigator)

Status	Finished
Effective start/end date	1/04/10 → 31/03/15

Total award	£1,500,000.00
Funding organisation	UK-based charities
Funder project reference	090281/Z/09/Z

Period	1/04/10 → 31/03/15

Research outputs

The Secreted Triose Phosphate Isomerase of Brugia malayi Is Required to Sustain Microfilaria Production In Vivo
Research output: Contribution to journal › Article › peer-review
IL-6 controls susceptibility to helminth infection by impeding Th2 responsiveness and altering the Treg phenotype in vivo
Research output: Contribution to journal › Article › peer-review
Concerted Activity of IgG1 Antibodies and IL-4/IL-25-Dependent Effector Cells Trap Helminth Larvae in the Tissues following Vaccination with Defined Secreted Antigens, Providing Sterile Immunity to Challenge Infection
Research output: Contribution to journal › Article › peer-review
Suppression of OVA-alum induced allergy by Heligmosomoides polygyrus products is MyD88-, TRIF-, regulatory T- and B cell-independent, but is associated with reduced innate lymphoid cell activation
Research output: Contribution to journal › Article › peer-review
Novel O-linked methylated glycan antigens decorate secreted immunodominant glycoproteins from the intestinal nematode Heligmosomoides polygyrus
Research output: Contribution to journal › Article › peer-review
Concerted IL-25R and IL-4Rα signaling drive innate type 2 effector immunity for optimal helminth expulsion
Research output: Contribution to journal › Article › peer-review