Edinburgh Research Explorer

Miinimal models of the circadian clock in a novael biological system

Project: Research

StatusFinished
Effective start/end date1/12/0731/05/11
Total award£418,372.00
Funding organisationBBSRC
Funder project referenceBB/F005466/1
Period1/12/0731/05/11

Key findings

Findings below are for the Edinburgh component of this joint grant. The full programme was run from France, by F-Y Bouget, who reports to the ANR in France. The University of Warwick also contributed to another publication.
a.Detailed and conceptual mathematical models of the Ostreococcus clock gene circuit showed the advantages of complexity in clock gene circuits (which Ostreococus lacks) and in their light inputs (which it has).
Troein et al. Current Biology, 2009.
Troein et al. Plant Journal, 2011; Biomodels ID TroeinOstreoClock_Jan2011.
b. Data on the rhythmic transcriptome in Ostreococcus were used to constrain the most detailed mathematical model of starch metabolism yet published, using a novel modelling method: this showed how this very simple cell can help us to understand more plant science than more complex, higher plant systems.
Sorokina et al. BMC Systems Biology, 2011.
c.Establishing Ostreococcus as an experimental system in Edinburgh: this allowed the paradigm-shifting demonstration of transcription-independent circadian rhythms and their coupling or uncoupling from the transcriptional clock gene circuit.
O’Neill et al. Nature, 2011.
Van Ooijen et al. Current Biology, 2011.

Activities

Press/Media

Research outputs