Research outputs

• Systematic review and stratified meta-analysis of the efficacy of RhoA and Rho kinase inhibitors in animal models of ischaemic stroke

  Research output: Contribution to journal › Article

• Disease-specific health-related quality of life (HRQL) instruments for food allergy: protocol for a systematic review

  Research output: Contribution to journal › Article

• Protocol for a systematic review and individual patient data meta-analysis of prognostic factors of foot ulceration in people with diabetes: the international research collaboration for the prediction of diabetic foot ulcerations (PODUS)

  Research output: Contribution to journal › Article

• Cytokine Gene Polymorphisms and Outcome after Traumatic Brain Injury

  Research output: Contribution to journal › Article

• Effect of thrombolysis with alteplase within 6 h of acute ischaemic stroke on long-term outcomes (the third International Stroke Trial [IST-3]): 18-month follow-up of a randomised controlled trial

  Research output: Contribution to journal › Article

• Advancing care for traumatic brain injury: findings from the IMPACT studies and perspectives on future research

  Research output: Contribution to journal › Article

• Study of therapeutic hypothermia (32 to 35°C) for intracranial pressure reduction after traumatic brain injury (the Eurotherm3235Trial): outcome of the pilot phase of the trial

  Research output: Contribution to journal › Article

• Targeted use of heparin, heparinoids, or low-molecular-weight heparin to improve outcome after acute ischaemic stroke: an individual patient data meta-analysis of randomised controlled trials

  Research output: Contribution to journal › Article

• Telemonitoring-based service redesign for the management of uncontrolled hypertension (HITS): cost and cost-effectiveness analysis of a randomised controlled trial

  Research output: Contribution to journal › Article

• Design and baseline characteristics of the PODOSA (Prevention of Diabetes & Obesity in South Asians) trial: a cluster, randomised lifestyle intervention in Indian and Pakistani adults with impaired glycaemia at high risk of developing type 2 diabetes

  Research output: Contribution to journal › Article

• Effectiveness of telemonitoring integrated into existing clinical services on hospital admission for exacerbation of chronic obstructive pulmonary disease: researcher blind, multicentre, randomised controlled trial

  Research output: Contribution to journal › Article

• Does intermittent pneumatic compression reduce the risk of post stroke deep vein thrombosis? The CLOTS 3 trial: statistical analysis plan

  Research output: Contribution to journal › Article

• Formal and informal prediction of recurrent stroke and myocardial infarction after stroke: a systematic review and evaluation of clinical prediction models in a new cohort

  Research output: Contribution to journal › Article

• Recombinant tissue plasminogen activator for acute ischaemic stroke: an updated systematic review and meta-analysis

  Research output: Contribution to journal › Article

• Acceptability and perceived barriers and facilitators to creating a national research register to enable 'direct to patient' enrolment into research: the Scottish Health Research Register (SHARE)

  Research output: Contribution to journal › Article

• Investigating the effectiveness of the Mediterranean diet in pregnant women for the primary prevention of asthma and allergy in high-risk infants: protocol for a pilot randomised controlled trial

  Research output: Contribution to journal › Article

• A concerted appeal for international cooperation in preclinical stroke research

  Research output: Contribution to journal › Article

• Scottish and Newcastle antiemetic pre-treatment for paracetamol poisoning study (SNAP)

  Research output: Contribution to journal › Article

• The impact of supported telemetric monitoring in people with type 2 diabetes: study protocol for a randomised controlled trial

  Research output: Contribution to journal › Article

• Outcome after surgical or conservative management of cerebral cavernous malformations

  Research output: Contribution to journal › Article

• Methodology of a large prospective, randomised, open, blinded endpoint streamlined safety study of celecoxib versus traditional non-steroidal anti-inflammatory drugs in patients with osteoarthritis or rheumatoid arthritis: protocol of the standard care versus celecoxib outcome trial (SCOT)

  Research output: Contribution to journal › Article

• Edaravone improves functional and structural outcomes in animal models of focal cerebral ischemia: A systematic review

  Research output: Contribution to journal › Article

• A randomised, double-blind, placebo-controlled phase IIB clinical trial of repeated application of gene therapy in patients with cystic fibrosis

  Research output: Contribution to journal › Article

• A randomized, controlled trial of simvastatin versus rosuvastatin in patients with acute myocardial infarction: the Secondary Prevention of Acute Coronary Events--Reduction of Cholesterol to Key European Targets Trial

  Research output: Contribution to journal › Article

• The Use of Blood Biomarkers to Predict Poor Outcome After Acute Transient Ischemic Attack or Ischemic Stroke

  Research output: Contribution to journal › Article

• Baseline characteristics and statistical power in randomized controlled trials: Selection, prognostic targeting, or covariate adjustment?

  Research output: Contribution to journal › Article

• Surgical trial in lobar intracerebral haemorrhage (STICH II) protocol

  Research output: Contribution to journal › Article

• Cancer pain and its relationship to systemic inflammation: an exploratory study

  Research output: Contribution to journal › Article

• Screening for Major Depression in Cancer Outpatients: The Diagnostic Accuracy of the 9-Item Patient Health Questionnaire

  Research output: Contribution to journal › Article

• How many patients might receive thrombolytic therapy in the light of the ECASS-3 and IST-3 data?

  Research output: Contribution to journal › Letter

• Blood biomarkers for the diagnosis of acute cerebrovascular diseases: a prospective cohort study

  Research output: Contribution to journal › Article

• Patients repeatedly referred to secondary care with symptoms unexplained by organic disease: prevalence, characteristics and referral pattern

  Research output: Contribution to journal › Article

• Scoring system to identify patients at high risk of oesophageal cancer

  Research output: Contribution to journal › Article

• Predictors of upper limb recovery after stroke: a systematic review and meta-analysis

  Research output: Contribution to journal › Article

• Symptoms 'unexplained by organic disease' in 1144 new neurology out-patients: how often does the diagnosis change at follow-up?

  Research output: Contribution to journal › Article

• Sleep problems in cancer patients: prevalence and association with distress and pain

  Research output: Contribution to journal › Article

• Disability, distress and unemployment in neurology outpatients with symptoms 'unexplained by organic disease'

  Research output: Contribution to journal › Article

• Treatment of depression in people with lung cancer: a systematic review

  Research output: Contribution to journal › Article

• European society of intensive care medicine study of therapeutic hypothermia (32-35 °C) for intracranial pressure reduction after traumatic brain injury (the Eurotherm3235Trial)

  Research output: Contribution to journal › Article

• Improving the translational hit of experimental treatments in multiple sclerosis

  Research output: Contribution to journal › Article

• The influence of enrollment criteria on recruitment and outcome distribution in traumatic brain injury studies: results from the impact study

  Research output: Contribution to journal › Article

• Neurology out-patients with symptoms unexplained by disease: illness beliefs and financial benefits predict 1-year outcome

  Research output: Contribution to journal › Article

• The Tayside Stroke Cohort: exploiting advanced regional medical informatics to create a region-wide database for studying the pharmacoepidemiology of stroke

  Research output: Contribution to journal › Article

• Restrictive Versus Liberal Transfusion Strategies for Older Mechanically Ventilated Critically Ill Patients: A Randomized Pilot Trial

  Research output: Contribution to journal › Article

• Sputum matrix metalloproteinase-12 in patients with chronic obstructive pulmonary disease and asthma: Relationship to disease severity

  Research output: Contribution to journal › Article

• Thoughts of Death and Suicide Reported by Cancer Patients Who Endorsed the "Suicidal Thoughts" Item of the PHQ-9 During Routine Screening for Depression

  Research output: Contribution to journal › Article

• Update on the Surgical Trial in Lobar Intracerebral Haemorrhage (STICH II): Statistical analysis plan

  Research output: Contribution to journal › Article

• Prevalence of depression in adults with cancer: a systematic review

  Research output: Contribution to journal › Article

• Inflammatory Markers and Poor Outcome after Stroke: A Prospective Cohort Study and Systematic Review of Interleukin-6

  Research output: Contribution to journal › Article

• Update on the third international stroke trial (IST-3) of thrombolysis for acute ischaemic stroke and baseline features of the 3035 patients recruited

  Research output: Contribution to journal › Article

• Can clinical features distinguish between immobile patients with stroke at high and low risk of deep vein thrombosis? Statistical modelling based on the CLOTS trials cohorts

  Research output: Contribution to journal › Article

• Prognostic value of major extracranial injury in traumatic brain injury: an individual patient data meta-analysis in 39,274 patients

  Research output: Contribution to journal › Article

• Automated data capture from free-text radiology reports to enhance accuracy of hospital inpatient stroke codes

  Research output: Contribution to journal › Article

• Nitrous oxide exposure does not seem to be associated with increased mortality, stroke, and myocardial infarction: a non-randomized subgroup analysis of the General Anaesthesia compared with Local Anaesthesia for carotid surgery (GALA) trial

  Research output: Contribution to journal › Article

• Persistence, adherence and outcomes with antiplatelet regimens following cerebral infarction in the Tayside Stroke Cohort

  Research output: Contribution to journal › Article

• The HSCL-20: One questionnaire, two versions

  Research output: Contribution to journal › Letter

• Relation Between Change in Blood Pressure in Acute Stroke and Risk of Early Adverse Events and Poor Outcome

  Research output: Contribution to journal › Article

• Prediction of outcome after moderate and severe traumatic brain injury: external validation of the International Mission on Prognosis and Analysis of Clinical Trials (IMPACT) and Corticoid Randomisation After Significant Head injury (CRASH) prognostic models

  Research output: Contribution to journal › Article

• The next step in understanding the prognosis of cerebral cavernous malformations

  Research output: Contribution to journal › Editorial

• Factors affecting the apparent efficacy and safety of tissue plasminogen activator in thrombotic occlusion models of stroke: systematic review and meta-analysis

  Research output: Contribution to journal › Article

• Statistical analysis plan for the third International Stroke Trial (IST-3); part of a 'thread' of reports of the trial

  Research output: Contribution to journal › Article

• Negative results: why do they need to be published?

  Research output: Contribution to journal › Article

• Preclinical drug evaluation for combination therapy in acute stroke using systematic review, meta-analysis, and subsequent experimental testing

  Research output: Contribution to journal › Article

• Recruiting South Asians to a lifestyle intervention trial: experiences and lessons from PODOSA (Prevention of Diabetes & Obesity in South Asians)

  Research output: Contribution to journal › Article

• A systematic review of clinical trials of pharmacological interventions for acute ischaemic stroke (1955-2008) that were completed, but not published in full

  Research output: Contribution to journal › Article

• Can Animal Models of Disease Reliably Inform Human Studies?

  Research output: Contribution to journal › Article

• Does the extended Glasgow Outcome Scale add value to the conventional Glasgow Outcome Scale?

  Research output: Contribution to journal › Article

• Fatigue after Stroke: Baseline Predictors and Influence on Survival. Analysis of Data from UK Patients Recruited in the International Stroke Trial

  Research output: Contribution to journal › Article

• Sitting Time and Waist Circumference Are Associated With Glycemia in UK South Asians: Data from 1,228 adults screened for the PODOSA trial

  Research output: Contribution to journal › Article

• Culturally adapting the prevention of diabetes and obesity in South Asians (PODOSA) trial

  Research output: Contribution to journal › Article

• No evidence of bias in the process of publication of diagnostic accuracy studies in stroke submitted as abstracts

  Research output: Contribution to journal › Article

• Bronchial nitric oxide flux (J ' aw) is sensitive to oral corticosteroids in smokers with asthma

  Research output: Contribution to journal › Article

• Death after head injury: the 13 year outcome of a case control study

  Research output: Contribution to journal › Article

• Spreading depolarisations and outcome after traumatic brain injury: a prospective observational study

  Research output: Contribution to journal › Article

• Application of variable life adjusted display (VLAD) to risk-adjusted mortality of esophagogastric cancer surgery

  Research output: Contribution to journal › Article

• Measuring improvement in depression in cancer patients: a 50% drop on the self-rated SCL-20 compared with a diagnostic interview

  Research output: Contribution to journal › Article

• Guided self-help for functional (psychogenic) symptoms: A randomized controlled efficacy trial

  Research output: Contribution to journal › Article

• Monitoring symptoms at home: what methods would cancer patients be comfortable using?

  Research output: Contribution to journal › Article

• The timing, extent, progression and regression of deep vein thrombosis in immobile stroke patients: observational data from the CLOTS multicenter randomized trials

  Research output: Contribution to journal › Article

• Pain, depression, and fatigue as a symptom cluster in advanced cancer

  Research output: Contribution to journal › Article

• Untreated clinical course of cerebral cavernous malformations: a prospective, population-based cohort study

  Research output: Contribution to journal › Article

• Early surgery versus initial conservative treatment in patients with spontaneous supratentorial lobar intracerebral haematomas (STICH II): a randomised trial

  Research output: Contribution to journal › Article

• Randomized comparison of uterine artery embolization (UAE) with surgical treatment in patients with symptomatic uterine fibroids (REST Trial): Subanalysis of 5-year MRI findings

  Research output: Contribution to journal › Article

• Clinical scores for the identification of stroke and transient ischaemic attack in the emergency department: a cross-sectional study

  Research output: Contribution to journal › Article

• Factors associated with outcome and duration of therapy in outpatient parenteral antibiotic therapy (OPAT) patients with skin and soft-tissue infections

  Research output: Contribution to journal › Article

• Publication Bias in Reports of Animal Stroke Studies Leads to Major Overstatement of Efficacy

  Research output: Contribution to journal › Article

• The added value of ordinal analysis in clinical trials: an example in traumatic brain injury

  Research output: Contribution to journal › Article

• Which neurological diseases are most likely to be associated with "symptoms unexplained by organic disease"

  Research output: Contribution to journal › Article

• Planning trials in older patients with stroke: data from the International Stroke Trial

  Research output: Contribution to journal › Article

• Systematic review of head cooling in adults after traumatic brain injury and stroke

  Research output: Contribution to journal › Article

• Prevalence, management, and outcomes of critically ill patients with prothrombin time prolongation in United Kingdom intensive care units

  Research output: Contribution to journal › Article

• Practical methodological strategies for individual patient data systematic reviews

  Research output: Contribution to journal › Article

• The quality of reporting of randomised controlled trials in asthma: Systematic review protocol

  Research output: Contribution to journal › Article

• Randomised comparison of uterine artery embolisation (UAE) with surgical treatment in patients with symptomatic uterine fibroids (REST trial): 5-year results

  Research output: Contribution to journal › Article

• Early prognosis in traumatic brain injury: from prophecies to predictions

  Research output: Contribution to journal › Article

• Characterization of cancer-induced bone pain: an exploratory study

  Research output: Contribution to journal › Article

• Effects of short-term treatment with atorvastatin in smokers with asthma--a randomized controlled trial

  Research output: Contribution to journal › Article

• Prescribing Antiplatelet Medicine and Subsequent Events After Intracerebral Hemorrhage

  Research output: Contribution to journal › Article

• Genetic Variation in the TNFRSF11A Gene Encoding RANK Is Associated With Susceptibility to Paget's Disease of Bone

  Research output: Contribution to journal › Article

• Hydrogel-coated coils versus bare platinum coils for the endovascular treatment of intracranial aneurysms (HELPS): a randomised controlled trial

  Research output: Contribution to journal › Article

• IMPACT Recommendations for Improving the Design and Analysis of Clinical Trials in Moderate to Severe Traumatic Brain Injury

  Research output: Contribution to journal › Article

• Large between-center differences in outcome after moderate and severe traumatic brain injury in the international mission on prognosis and clinical trial design in traumatic brain injury (IMPACT) study

  Research output: Contribution to journal › Article

• The angiotensin-receptor blocker candesartan for treatment of acute stroke (SCAST): a randomised, placebo-controlled, double-blind trial: a randomised, placebo-controlled, double-blind trial

  Research output: Contribution to journal › Article

• The effects of uterine artery embolisation and surgical treatment on ovarian function in women with uterine fibroids

  Research output: Contribution to journal › Article

• The International Stroke Trial database

  Research output: Contribution to journal › Article

• Aspirin for Prevention of Cardiovascular Events in a General Population Screened for a Low Ankle Brachial Index: A Randomized Controlled Trial

  Research output: Contribution to journal › Article

• Population-based trends in pregnancy hypertension and pre-eclampsia: An international comparative study

  Research output: Contribution to journal › Article

• Treatment of depression in adults with cancer: A systematic review of randomized controlled trials

  Research output: Contribution to journal › Article

• Association of Circulating Inflammatory Markers With Recurrent Vascular Events After Stroke: A Prospective Cohort Study

  Research output: Contribution to journal › Article

• Screening for suicidality in cancer patients using Item 9 of the nine-item patient health questionnaire; does the item score predict who requires further assessment?

  Research output: Contribution to journal › Article

• Who is referred to neurology clinics?--the diagnoses made in 3781 new patients

  Research output: Contribution to journal › Article

• Comparison of Statistical and Clinical Predictions of Functional Outcome after Ischemic Stroke

  Research output: Contribution to journal › Article

• Systematic Review of Observational Research Studying the Long-Term use of Antithrombotic Medicines Following Intracerebral Hemorrhage

  Research output: Contribution to journal › Article

• A simulation study evaluating approaches to the analysis of ordinal outcome data in randomized controlled trials in traumatic brain injury: results from the IMPACT Project

  Research output: Contribution to journal › Article

• Patient and general practitioner preferences for the treatment of depression in patients with cancer: How, who, and where?

  Research output: Contribution to journal › Article

• Surviving intensive care: a systematic review of healthcare resource use after hospital discharge*

  Research output: Contribution to journal › Article

• Sliding dichotomy compared with fixed dichotomization of ordinal outcome scales in subarachnoid hemorrhage trials Clinical article

  Research output: Contribution to journal › Article

• Pain in Patients Attending a Specialist Cancer Service: Prevalence and Association With Emotional Distress

  Research output: Contribution to journal › Article

• Making randomised trials more efficient: report of the first meeting to discuss the Trial Forge platform

  Research output: Contribution to journal › Article

• The Glasgow Coma Scale at 40 years: Standing the test of time

  Research output: Contribution to journal › Article

• Targeted rehabilitation to improve outcome after total knee replacement (TRIO): study protocol for a randomised controlled trial

  Research output: Contribution to journal › Article

• Cost-effectiveness of combining systematic identification and treatment of co-morbid major depression for people with chronic diseases: the example of cancer

  Research output: Contribution to journal › Article

• A rehabilitation intervention to promote physical recovery following intensive care: A detailed description of construct development, rationale and content together with proposed taxonomy to capture processes in a randomised controlled trial

  Research output: Contribution to journal › Article

• Targeting aspirin in acute disabling ischemic stroke: an individual patient data meta-analysis of three large randomized trials

  Research output: Contribution to journal › Article

• Somatic symptom count scores do not identify patients with symptoms unexplained by disease: a prospective cohort study of neurology outpatients

  Research output: Contribution to journal › Article

• Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials

  Research output: Contribution to journal › Article

• Group therapy for people with bulimia nervosa: Systematic review and meta-analysis

  Research output: Contribution to journal › Article

• Development and validation of an ankle brachial index risk model for the prediction of cardiovascular events

  Research output: Contribution to journal › Article

• A meta-analysis of genome-wide association studies identifies novel variants associated with osteoarthritis of the hip

  Research output: Contribution to journal › Article

• Response to Letter Regarding Article, "Targeting Recombinant Tissue-Type Plasminogen Activator in Acute Ischemic Stroke Based on Risk of Intracranial Hemorrhage or Poor Functional Outcome: An Analysis of the Third International Stroke Trial"

  Research output: Contribution to journal › Letter

• Simvastatin in aneurysmal subarachnoid haemorrhage (STASH): A multicentre randomised phase 3 trial

  Research output: Contribution to journal › Article

• Integrated collaborative care for major depression comorbid with a poor prognosis cancer (SMaRT Oncology-3): a multicentre randomised controlled trial in patients with lung cancer

  Research output: Contribution to journal › Article

• Clinical course of untreated cerebral cavernous malformations: an individual patient data meta-analysis

  Research output: Contribution to journal › Article

• Arterial Obstruction on Computed Tomographic or Magnetic Resonance Angiography and Response to Intravenous Thrombolytics in Ischemic Stroke

  Research output: Contribution to journal › Article