MRC Human Genetics Core Grant

Project: Funded Project › Research

Wright, Alan (Principal investigator)
Hastie, Nick (Co-investigator)
Jackson, Ian (Co-investigator)
Baldock, Richard (Co-investigator)
Bickmore, Wendy (Co-investigator)
FitzPatrick, David (Co-investigator)
Jackson, Andrew (Co-investigator)
Hill, Bob (Co-investigator)
Dorin, Julia (Co-investigator)
Caceres, Javier (Co-investigator)
Adams, Ian (Co-investigator)
Haley, Chris (Co-investigator)
Meehan, Richard (Co-investigator)
Van Heyningen, Veronica (Co-investigator)
Patton, Elizabeth (Co-investigator)
Taylor, Martin (Co-investigator)
Aligianis, Irene (Co-investigator)
O'Connell, Mary (Co-investigator)
Kudla, Grzegorz (Co-investigator)
Overton, Ian (Co-investigator)
Dunlop, Malcolm (Co-investigator)
Tenesa, Albert (Co-investigator)

Total award	£14,985,116.00
Funding organisation	MRC
Funder project reference	CORE FUNDS 12/13
Period	1/04/12 → 31/07/13

Related research outputs

Local exome sequences facilitate imputation of less common variants and increase power of genome wide association studies
Research output: Contribution to journal › Article
Partial Deletion of Chromosome 8 β-defensin Cluster Confers Sperm Dysfunction and Infertility in Male Mice
Research output: Contribution to journal › Article
Inference of identity by descent in population isolates and optimal sequencing studies
Research output: Contribution to journal › Article
Genomic Prediction for Complex Traits Following Feature Selection: Results from Bayes C and Genomic Best Linear Unbiased Prediction (G-BLUP)
Research output: Contribution to journal › Meeting abstract
Loss of ALDH18A1 function is associated with a cellular lipid droplet phenotype suggesting a link between autosomal recessive cutis laxa type 3A and Warburg Micro syndrome
Research output: Contribution to journal › Article
Leveraging Different Sources of Signal in Genomic Predictions of Complex Traits
Research output: Contribution to journal › Meeting abstract
The power of regional heritability analysis for rare and common variant detection: simulations and application to eye biometrical traits
Research output: Contribution to journal › Article
Disruption of SATB2 or its long-range cis-regulation by SOX9 causes a syndromic form of Pierre Robin Sequence
Research output: Contribution to journal › Article
Using Haplotype Mapping to Uncover the Missing Heritability: A Simulation Study
Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
Comparative performance of four methods for high-throughput glycosylation analysis of immunoglobulin G in genetic and epidemiological research
Research output: Contribution to journal › Article
Glycans Are a Novel Biomarker of Chronological and Biological Ages
Research output: Contribution to journal › Article
Predicting body mass index and waist-hip ratio from genome-wide single nucleotide polymorphism data.
Research output: Contribution to conference › Paper
Genomic prediction for complex traits following feature selection: results from Bayes C and genomic best linear unbiased prediction (G-BLUP).
Research output: Contribution to conference › Paper
Genome Wide Association Identifies Common Variants at the SERPINA6/SERPINA1 Locus Influencing Plasma Cortisol and Corticosteroid Binding Globulin
Research output: Contribution to journal › Article
Genomic prediction of health traits in humans: demonstrating the value of marker selection.
Research output: Contribution to conference › Paper
Combining different sources of information to optimise genomic prediction of complex traits
Research output: Contribution to conference › Poster
Developing the eHistology Atlas
Research output: Contribution to journal › Article
Oocyte Development, Meiosis and Aneuploidy
Research output: Contribution to journal › Article
Lsh is essential for maintaining global DNA methylation levels in amphibia and fish and interacts directly with Dnmt1
Research output: Contribution to journal › Article
The E3 ubiquitin ligase activity of Ring1B is not essential for early mouse development
Research output: Contribution to journal › Article
The goya mouse mutant reveals distinct newly identified roles for MAP3K1 in the development and survival of cochlear sensory hair cells
Research output: Contribution to journal › Article
Lineage tracing in the adult mouse corneal epithelium supports the limbal epithelial stem cell hypothesis with intermittent periods of stem cell quiescence
Research output: Contribution to journal › Article
Chromatin at the nuclear periphery and the regulation of genome functions
Research output: Contribution to journal › Article
Effects of CreERT2, 4-OH Tamoxifen, and Gender on CFU-F Assays
Research output: Contribution to journal › Article
Genome-wide mapping of embedded ribonucleotides and other noncanonical nucleotides using emRiboSeq and EndoSeq
Research output: Contribution to journal › Article
Two novel mutations in RNU4ATAC in two siblings with an atypical mild phenotype of microcephalic osteodysplastic primordial dwarfism type 1
Research output: Contribution to journal › Article
Reconciling diverse mammalian pigmentation patterns with a fundamental mathematical model
Research output: Contribution to journal › Article
The RNA helicase DHX34 functions as a scaffold for SMG1-mediated UPF1 phosphorylation
Research output: Contribution to journal › Article
MEK Inhibitors Reverse cAMP-Mediated Anxiety in Zebrafish
Research output: Contribution to journal › Article
eMouseAtlas Informatics: Embryo Atlas and Gene Expression
Research output: Contribution to journal › Article
Mouse anatomy ontologies: enhancements and tools for exploring and integrating biomedical data
Research output: Contribution to journal › Article
Discovery of four recessive developmental disorders using probabilistic genotype and phenotype matching among 4,125 families
Research output: Contribution to journal › Letter
DGCR8 acts as an adaptor for the exosome complex to degrade double-stranded structured RNAs
Research output: Contribution to journal › Article
A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants
Research output: Contribution to journal › Article
Assessment of biocompatibility of 3D printed photopolymers using zebrafish embryo toxicity assays
Research output: Contribution to journal › Article
Enhancer Turnover Is Associated with a Divergent Transcriptional Response to Glucocorticoid in Mouse and Human Macrophages
Research output: Contribution to journal › Article
Whole exome sequencing in an isolated population from the Dalmatian island of Vis
Research output: Contribution to journal › Article
Loss of Tet1 associated 5-hydroxymethylcytosine is concomitant with aberrant promoter hypermethylation in liver cancer
Research output: Contribution to journal › Article
Rapid Discovery and Structure-Activity Relationships of Pyrazolopyrimidines that Potently Suppress Breast Cancer Cell Growth via SRC Kinase Inhibition with Exceptional Selectivity over ABL Kinase
Research output: Contribution to journal › Article
A Restricted Repertoire of De Novo Mutations in ITPR1 Cause Gillespie Syndrome with Evidence for Dominant Negative Effect
Research output: Contribution to journal › Article
A TAD Closer to Understanding Dosage Compensation
Research output: Contribution to journal › Article
The Hierarchy of Transcriptional Activation: From Enhancer to Promoter
Research output: Contribution to journal › Literature review
Evaluating the contribution of genetic and familial shared environment to common disease using the UK Biobank
Research output: Contribution to journal › Article
An Empirical Comparison of Joint and Stratified Frameworks for Studying G × E Interactions: Systolic Blood Pressure and Smoking in the CHARGE Gene-Lifestyle Interactions Working Group
Research output: Contribution to journal › Article
Chromatin decondensation is sufficient to alter nuclear organization in embryonic stem cells
Research output: Contribution to journal › Article
PRC2-independent chromatin compaction and transcriptional repression in cancer
Research output: Contribution to journal › Article
Extreme Growth Failure is a Common Presentation of Ligase IV Deficiency
Research output: Contribution to journal › Article
Genetic Analysis of 'PAX6-Negative' Individuals with Aniridia or Gillespie Syndrome
Research output: Contribution to journal › Article
Mechanism and regulation of the nonsense-mediated decay pathway
Research output: Contribution to journal › Article
The RNA-binding profile of Acinus, a peripheral component of the Exon junction complex, reveals its role in splicing regulation
Research output: Contribution to journal › Article
Epidemiology and Heritability of Major Depressive Disorder, Stratified by Age of Onset, Sex, and Illness Course in Generation Scotland: Scottish Family Health Study (GS:SFHS)
Research output: Contribution to journal › Article
5-Hydroxymethylcytosine Remodeling Precedes Lineage Specification during Differentiation of Human CD4(+) T Cells
Research output: Contribution to journal › Article
Is there a role for DAZL in human female fertility?
Research output: Contribution to journal › Article
Network of Epistatic Interactions Within a Yeast snoRNA
Research output: Contribution to journal › Article
The hierarchy of transcriptional activation: from enhancer to promoter
Research output: Non-textual form › Web publication/site
Shh and ZRS enhancer co-localisation is specific to the zone of polarizing activity
Research output: Contribution to journal › Article
Polycomb-mediated chromatin compaction weathers the STORM
Research output: Contribution to journal › Article
Lineage-specific genomics: Frequent birth and death in the human genome: The human genome contains many lineage-specific elements created by both sequence and functional turnover
Research output: Contribution to journal › Article
Strand-specific, high-resolution mapping of modified RNA polymerase II
Research output: Contribution to journal › Article
Histone H3 globular domain acetylation identifies a new class of enhancers
Research output: Contribution to journal › Article
Mutations in CDC45, Encoding an Essential Component of the Pre-initiation Complex, Cause Meier-Gorlin Syndrome and Craniosynostosis
Research output: Contribution to journal › Article
Mutational Biases Drive Elevated Rates of Substitution at Regulatory Sites across Cancer Types
Research output: Contribution to journal › Article
Etoposide Damages Female Germ Cells in the Developing Ovary
Research output: Contribution to journal › Article
Condensin II mutation causes T cell lymphoma through tissue-specific genome instability
Research output: Contribution to journal › Article
Mutations in genes encoding condensin complex proteins cause microcephaly through decatenation failure at mitosis
Research output: Contribution to journal › Article
The RNA-binding landscape of RBM10 and its role in alternative splicing regulation in models of mouse early development
Research output: Contribution to journal › Article