RA2662 Centre for Cognitive Ageing and Cognitive Epidemiology Phase 2.

Project: Research

Porteous, David (Principal Investigator)

Status	Finished
Effective start/end date	1/09/13 → 31/08/19

Period	1/09/13 → 31/08/19

Research outputs

DNA methylation and the epigenetic clock in relation to physical frailty in older people: The Lothian Birth Cohort 1936
Research output: Contribution to journal › Article › peer-review
Poor coherence in older people's speech is explained by impaired semantic and executive processes
Research output: Contribution to journal › Article › peer-review
Polygenic risk of ischemic stroke is associated with cognitive ability
Research output: Contribution to journal › Article › peer-review
DNA methylation levels at individual age-associated CpG sites can be indicative for life expectancy
Research output: Contribution to journal › Article › peer-review
Enrichment of genetic markers of recent human evolution in educational and cognitive traits
Research output: Contribution to journal › Article › peer-review
Role of cognitive ability in the association between functional health literacy and mortality in the Lothian Birth Cohort 1936: A prospective cohort study
Research output: Contribution to journal › Article › peer-review
GWAS analysis of handgrip and lower body strength in older adults in the CHARGE consortium
Research output: Contribution to journal › Article › peer-review
Genome-wide analysis of over 106,000 individuals identifies 9 neuroticism-associated loci
Research output: Contribution to journal › Article › peer-review
Mind over memory: Cueing the aging brain
Research output: Contribution to journal › Article › peer-review
Cognitive Test Scores in UK Biobank: Data Reduction in 480,416 Participants and Longitudinal Stability in 20,346 Participants
Research output: Contribution to journal › Article › peer-review
Childhood characteristics and participation in Scottish Mental Survey 1947 6-day sample follow-ups: Implications for participation in aging studies
Research output: Contribution to journal › Article › peer-review
Genome-wide association study of cognitive functions and educational attainment in UK Biobank (N=112 151)
Research output: Contribution to journal › Article › peer-review
Gender differences in marital status moderation of genetic and environmental influences on subjective health
Research output: Contribution to journal › Article › peer-review
Personality stability from age 14 to age 77 years
Research output: Contribution to journal › Article › peer-review
Common variation in COL4A1/COL4A2 is associated with sporadic cerebral small vessel disease
Research output: Contribution to journal › Article › peer-review
Associations between single and multiple cardiometabolic diseases and cognitive abilities in 474 129 UK Biobank participants
Research output: Contribution to journal › Article › peer-review
Molecular genetic contributions to social deprivation and household income in UK biobank
Research output: Contribution to journal › Article › peer-review
Prevalence and correlates of cognitive impairment in euthymic adults with bipolar disorder: A systematic review
Research output: Contribution to journal › Article › peer-review
Genome-wide Association for Major Depression Through Age at Onset Stratification: Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium
Research output: Contribution to journal › Article › peer-review
Genetic variants linked to education predict longevity
Research output: Contribution to journal › Article › peer-review
Fast set-based association analysis using summary data from GWAS identifies novel gene loci for human complex traits
Research output: Contribution to journal › Article › peer-review
Epigenetic signatures of starting and stopping smoking
Research output: Contribution to journal › Article › peer-review
Cohort Profile: Stratifying Resilience and Depression Longitudinally (STRADL): A questionnaire follow-up of Generation Scotland: Scottish Family Health Study (GS:SFHS)
Research output: Contribution to journal › Article › peer-review
Exploration of haplotype research consortium imputation for genome-wide association studies in 20,032 Generation Scotland participants
Research output: Contribution to journal › Article › peer-review
High-resolution MR Elastography (MRE) reveals differences in Subcortical Gray Matter Viscoelasticity between Young and Healthy Older Adults
Research output: Contribution to journal › Article › peer-review
Association of methylation signals with incident coronary heart disease in an epigenome-wide assessment of circulating tumor necrosis factor α
Research output: Contribution to journal › Article › peer-review
Polygenic predictors of age-related decline in cognitive ability
Research output: Contribution to journal › Article › peer-review
GWAS on family history of Alzheimer’s disease
Research output: Contribution to journal › Article › peer-review
DNA methylome profiling of all-cause mortality in comparison with age-associated methylation patterns
Research output: Contribution to journal › Article › peer-review
Hypertension development by midlife and the roles of pre-morbid cognition function, sex, and their interaction
Research output: Contribution to journal › Article › peer-review
Association between APOE e4 and white matter hyperintensity volume, but not total brain volume or white matter integrity
Research output: Contribution to journal › Article › peer-review
Genetic contributions to two special factors of neuroticism are associated with affluence, higher intelligence, better health
Research output: Contribution to journal › Article › peer-review
Associations between dietary inflammatory index scores and inflammatory biomarkers among older adults in the Lothian Birth Cohort 1936 study
Research output: Contribution to journal › Article › peer-review
Parent of origin genetic effects on methylation in humans are common and influence complex trait variation
Research output: Contribution to journal › Article › peer-review
Association Between the Activity Space Exposure to Parks in Childhood and Adolescence and Cognitive Aging in Later Life
Research output: Contribution to journal › Article › peer-review
Age‐dependent DNA methylation patterns on the Y chromosome in elderly males
Research output: Contribution to journal › Article › peer-review
The influence of X chromosome variants on trait neuroticism
Research output: Contribution to journal › Article › peer-review
Genetic contributions to health literacy
Research output: Contribution to journal › Article › peer-review
A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure
Research output: Contribution to journal › Article › peer-review
Smoking does not accelerate leucocyte telomere attrition: A meta-analysis of 18 longitudinal cohorts
Research output: Contribution to journal › Article › peer-review
Impact of polygenic risk for Schizophrenia on cortical structure in UK Biobank
Research output: Contribution to journal › Article › peer-review
Stratifying major depressive disorder by polygenic risk for schizophrenia in relation to structural brain measures
Research output: Contribution to journal › Article › peer-review
Pleiotropic meta-analysis of cognition, education, and schizophrenia differentiates roles of early neurodevelopmental and adult synaptic pathways
Research output: Contribution to journal › Article › peer-review
Early-life predictors of retirement decisions and post-retirement health
Research output: Contribution to journal › Article › peer-review
Understanding cognitive impairment in mood disorders: Mediation analyses in the UK Biobank cohort
Research output: Contribution to journal › Article › peer-review
Age-related clonal haematopoiesis is associated with increased epigenetic age
Research output: Contribution to journal › Article › peer-review
Epigenetic signatures of smoking associate with cognitive function, brain structure, and mental and physical health outcomes in the Lothian Birth Cohort 1936
Research output: Contribution to journal › Article › peer-review
OSCA: A tool for omic-data-based complex trait analysis
Research output: Contribution to journal › Article › peer-review
Genome and epigenome wide studies of neurological protein biomarkers in the Lothian Birth Cohort 1936
Research output: Contribution to journal › Article › peer-review
The genetic architecture of the human cerebral cortex
Research output: Contribution to journal › Article › peer-review
Weighted gene co-regulation network analysis (WGCNA) of promoter DNA methylation on all-cause mortality in old-aged birth cohorts finds modules of high-risk associated biomarkers
Research output: Contribution to journal › Article › peer-review
Epigenomic assessment of cardiovascular disease risk and interactions with traditional risk metrics
Research output: Contribution to journal › Article › peer-review
The long arm of childhood intelligence on terminal decline: Evidence from the Lothian Birth Cohort 1921
Research output: Contribution to journal › Article › peer-review
Aging-sensitive networks within the human structural connectome are implicated in late-life cognitive declines.
Research output: Contribution to journal › Article › peer-review
DNA methylation outlier burden, health and ageing in Generation Scotland and the Lothian Birth Cohorts of 1921 and 1936
Research output: Contribution to journal › Article › peer-review
DNA methylation in APOE: The relationship with Alzheimer’s and with cardiovascular health
Research output: Contribution to journal › Article › peer-review
Epigenetic prediction of major depressive disorder
Research output: Contribution to journal › Article › peer-review
Association of childhood psychomotor coordination with survival up to 6 decades later
Research output: Contribution to journal › Article › peer-review
Generation of twenty four induced pluripotent stem cell lines from twenty four members of the Lothian 4 Birth Cohort 1936
Research output: Contribution to journal › Article › peer-review
Blood DNA methylation sites predict death risk in a longitudinal study of 12,300 individuals
Research output: Contribution to journal › Article › peer-review
Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci
Research output: Contribution to journal › Article › peer-review
Psychosocial factors and hospitalisations for COVID-19: Prospective cohort study based on a community sample
Research output: Contribution to journal › Article › peer-review
Epigenetic measures of ageing predict prevalence and incidence of leading causes of death and disease burden
Research output: Contribution to journal › Article › peer-review
Is healthy neuroticism associated with longevity? A coordinated integrative data analysis
Research output: Contribution to journal › Article › peer-review
The relationship between white matter microstructure and general cognitive ability in patients with schizophrenia and healthy participants in the ENIGMA Consortium
Research output: Contribution to journal › Article › peer-review
Exploratory analysis of age and sex dependent DNA methylation patterns on the X-chromosome in whole blood samples
Research output: Contribution to journal › Article › peer-review
Bayesian reassessment of the epigenetic architecture of complex traits
Research output: Contribution to journal › Article › peer-review
Whole blood DNA methylation signatures of diet are associated with cardiovascular disease risk factors and all-cause mortality
Research output: Contribution to journal › Article › peer-review
Psychotic-like experiences, polygenic risk scores for schizophrenia, and structural properties of the salience, default mode, and central-executive networks in healthy participants from UK Biobank
Research output: Contribution to journal › Article › peer-review
Is healthy neuroticism associated with chronic conditions? A coordinated integrative data analysis
Research output: Contribution to journal › Article › peer-review
Multi-method genome and epigenome wide studies of inflammatory protein levels in healthy older adults
Research output: Contribution to journal › Article › peer-review
Characterisation of an inflammation-related epigenetic score and its association with cognitive ability
Research output: Contribution to journal › Article › peer-review
A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank
Research output: Contribution to journal › Article › peer-review
Is healthy neuroticism associated with health behaviors? A coordinated integrative data analysis
Research output: Contribution to journal › Article › peer-review