Edinburgh Research Explorer

The infuence of galt in tse agent in neuroinvasion from the large intestine

Project: Research

StatusFinished
Effective start/end date5/05/0931/10/12
Total award£437,902.00
Funding organisationBBSRC
Funder project referenceBB/G003947/1
Period5/05/0931/10/12

Key findings

-Demonstrated that M cells are the main route of TSE agent uptake from the small intestine after oral exposure.



-Demonstrated for the first time that distinct mechanisms regulate the development of the GALT in the large and small intestines.



-Demonstrated for the first time that the large intestine is not a primary site of TSE agent neuroinvasion after oral exposure.



-Demonstrated for the first time that congruent parasite infection in the large intestine does not influence oral TSE pathogenesis or susceptibility.



-Demonstrated for the first time that a congruent parasite infection in the large intestine can exacerbate the onset of clinical TSE disease.



-Project still in progress and will be published as soon as ready.

Press/Media

Research outputs