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A comprehensive evaluation of potential lung function associated genes in the SpiroMeta general population sample

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  • Ma'en Obeidat
  • Louise V Wain
  • Nick Shrine
  • Noor Kalsheker
  • Maria Soler Artigas
  • Emmanouela Repapi
  • Paul R Burton
  • Toby Johnson
  • Adaikalavan Ramasamy
  • Jing Hua Zhao
  • Guangju Zhai
  • Jennifer E Huffman
  • Veronique Vitart
  • Eva Albrecht
  • Wilmar Igl
  • Anna-Liisa Hartikainen
  • Anneli Pouta
  • Gemma Cadby
  • Jennie Hui
  • Lyle J Palmer
  • David Hadley
  • Wendy L McArdle
  • Alicja R Rudnicka
  • Inês Barroso
  • Ruth J F Loos
  • Nicholas J Wareham
  • Massimo Mangino
  • Nicole Soranzo
  • Tim D Spector
  • Sven Gläser
  • Georg Homuth
  • Henry Völzke
  • Panos Deloukas
  • Raquel Granell
  • John Henderson
  • Ivica Grkovic
  • Stipan Jankovic
  • Lina Zgaga
  • Ozren Polašek
  • Igor Rudan
  • Alan F Wright
  • Harry Campbell
  • Sarah H Wild
  • James F Wilson
  • Joachim Heinrich
  • Medea Imboden
  • Nicole M Probst-Hensch
  • Ulf Gyllensten
  • Åsa Johansson
  • Caroline Hayward
  • SpiroMeta Consortium

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    Rights statement: Copyright: © 2011 Obeidat et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0019382
Original languageEnglish
Pages (from-to)e19382
JournalPLoS ONE
Volume6
Issue number5
DOIs
Publication statusPublished - 2011

Abstract

Lung function measures are heritable traits that predict population morbidity and mortality and are essential for the diagnosis of chronic obstructive pulmonary disease (COPD). Variations in many genes have been reported to affect these traits, but attempts at replication have provided conflicting results. Recently, we undertook a meta-analysis of Genome Wide Association Study (GWAS) results for lung function measures in 20,288 individuals from the general population (the SpiroMeta consortium).

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