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A comprehensive machine-readable view of the mammalian cholesterol biosynthesis pathway

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Original languageEnglish
Pages (from-to)56-66
Number of pages11
JournalBiochemical Pharmacology
Volume86
Issue number1
Early online date10 Apr 2013
DOIs
Publication statusPublished - 1 Jul 2013

Abstract

Cholesterol biosynthesis serves as a central metabolic hub for numerous biological processes in health and disease. A detailed, integrative single-view description of how the cholesterol pathway is structured and how it interacts with other pathway systems is lacking in the existing literature. Here we provide a systematic review of the existing literature and present a detailed pathway diagram that describes the cholesterol biosynthesis pathway (the mevalonate, the Kandutch-Russell and the Bloch pathway) and shunt pathway that leads to 24(S),25-epoxycholesterol synthesis. The diagram has been produced using the Systems Biology Graphical Notation (SBGN) and is available in the SBGN-ML format, a human readable and machine semantically parsable open community file format.


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    Research areas

  • Cholesterol, Sterol, SBGN, Metabolic network, Pathway map, ISOPENTENYL DIPHOSPHATE ISOMERASE, MEVALONATE PYROPHOSPHATE DECARBOXYLASE, CYTOCHROME P450 OXIDOREDUCTASE, PEROXISOMAL TARGETING SIGNALS, COA LYASE DEFICIENCY, PHOSPHOMEVALONATE KINASE, SQUALENE SYNTHASE, NEURODEGENERATIVE DISEASES, ISOPRENOID BIOSYNTHESIS, ENDOPLASMIC-RETICULUM

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