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A Conserved Oct4/POUV-Dependent Network Links Adhesion and Migration to Progenitor Maintenance

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Original languageEnglish
Pages (from-to)2233-2244
Number of pages12
JournalCurrent biology : CB
Volume23
Issue number22
DOIs
Publication statusPublished - 6 Nov 2013

Abstract

The class V POU domain transcription factor Oct4 (Pou5f1) is a pivotal regulator of embryonic stem cell (ESC) self-renewal and reprogramming of somatic cells to induced pluripotent stem (iPS) cells. Oct4 is also an important evolutionarily conserved regulator of progenitor cell differentiation during embryonic development.

    Research areas

  • EMBRYONIC STEM-CELLS, TRANSCRIPTIONAL REGULATORY CIRCUITRY, E-CADHERIN, XENOPUS-EMBRYOS, BETA-CATENIN, OCT4, PLURIPOTENCY, EXPRESSION, PROTEIN, DIFFERENTIATION

ID: 11186153