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A generic small-molecule microarray immobilization strategy

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Original languageEnglish
Pages (from-to)6819-6822
Number of pages4
JournalTetrahedron Letters
Volume52
Issue number50
DOIs
Publication statusPublished - 14 Dec 2011

Abstract

Small-molecule microarrays are often limited by the requirement for each compound undergoing immobilization to contain a common functional group or by the need to prepare glass slides containing photo-reactive groups. Herein, we present a generic strategy that allows any compound library to be immobilized. This was achieved by printing a fluorous-tagged photo-reactive 3-aryl-3-trifluoromethyldiazirine, which undergoes non-selective insertion into compounds following UV-activation, onto fluorous-functionalized glass slides. The arrays could be reused following aqueous stripping and re-assessment of the compounds with the same protein or another target of interest. Crown Copyright (C) 2011 Published by Elsevier Ltd. All rights reserved.

    Research areas

  • Small-molecule microarrays, Photoreactive functional groups, Microwave-assisted synthesis, Fluorous affinity, CARBOHYDRATE MICROARRAYS, LIGAND DISCOVERY, INHIBITORS, PROTEINS, ARRAYS, TOOLS

ID: 1463181