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A Highly Selective Fluorescent Probe for Direct Detection and Isolation of Mouse Embryonic Stem Cells

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  • Yogeswari Chandran
  • Nam-Young Kang
  • Sung-Jin Park
  • Samira Husen Alamudi
  • Jun-Young Kim
  • Srikanta Sahu
  • Dongdong Su
  • Jungyeol Lee
  • Marc Vendrell
  • Young-Tae Chang

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http://www.sciencedirect.com/science/article/pii/S0960894X15006307
Original languageEnglish
JournalBioorganic & Medicinal Chemistry Letters
Volume25
Issue number21
Early online date16 Jun 2015
DOIs
Publication statusPublished - 1 Nov 2015

Abstract

Stem cell research has gathered immense attention in the past decade due to the remarkable ability of stem cells for self-renewal and tissue-specific differentiation. Despite having numerous advancements in stem cell isolation and manipulation techniques, there is a need for highly reliable probes for the specific detection of live stem cells. Herein we developed a new fluorescence probe (CDy9) with high selectivity for mouse embryonic stem cells. CDy9 allows the detection and isolation of intact stem cells with marginal impact on their function and capabilities.

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