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A highly sensitive fluorescent viscosity sensor

Research output: Contribution to journalArticle

Original languageEnglish
Pages (from-to)5780-5783
Number of pages4
JournalBioorganic & Medicinal Chemistry Letters
Volume22
Issue number18
DOIs
Publication statusPublished - 15 Sep 2012

Abstract

Variation at the 3' position of fluorescein via Suzuki-Miyaura cross-coupling with aryl and heteroaryl moieties gave a family of anthofluoresceins whose spectroscopic properties were studied. The 1-methylindole derivative gave the highest quantum yield and was observed to behave as a molecular rotor, displaying marked variations in fluorescent intensities with viscosity and offering possible application in cellular sensing and fluorescent polarisation assays.

    Research areas

  • BIOLOGY, DYES, MICROSPHERES, Fluorescein, Palladium catalysis, LIVING CELLS, PROBES, Viscosity sensor, Suzuki cross-coupling, MOLECULAR ROTORS, CHEMISTRY, Anthofluorescein, SINGLE-CELL

ID: 7945696