Edinburgh Research Explorer

A logic-based diagram of signalling pathways central to macrophage activation

Research output: Contribution to journalArticle

Related Edinburgh Organisations

Open Access permissions

Open

Documents

  • Download as Adobe PDF

    Rights statement: This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

    Final published version, 2 MB, PDF document

Original languageEnglish
Article number36
JournalBMC Systems Biology
Volume2
DOIs
Publication statusPublished - 2008

Abstract

The complex yet flexible cellular response to pathogens is orchestrated by the interaction of multiple signalling and metabolic pathways. The molecular regulation of this response has been studied in great detail but comprehensive and unambiguous diagrams describing these events are generally unavailable. Four key signalling cascades triggered early-on in the innate immune response are the toll-like receptor, interferon, NF-kappaB and apoptotic pathways, which co-operate to defend cells against a given pathogen. However, these pathways are commonly viewed as separate entities rather than an integrated network of molecular interactions.

    Research areas

  • Animals, Audiovisual Aids, Bone Marrow, Cells, Cultured, Computer Graphics, Immunity, Innate, Interferons, Logic, Macrophage Activation, Male, Mice, Mice, Inbred BALB C, Models, Biological, Monocytes, NF-kappa B, Protein Interaction Mapping, Signal Transduction, Systems Biology, Systems Integration, Toll-Like Receptors, p38 Mitogen-Activated Protein Kinases

Download statistics

No data available

ID: 1393068