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A novel S-nitrosothiol causes prolonged and selective inhibition of platelet adhesion at sites of vascular injury

Research output: Contribution to journalArticle

Original languageEnglish
Pages (from-to)853-60
Number of pages8
JournalCardiovascular Research
Volume57
Issue number3
Publication statusPublished - 2003

Abstract

Platelet adhesion to areas of endothelial denudation following angioplasty is an important factor contributing to the limitations of this technique. Lipophilic S-nitrosothiols like S-nitroso-N-valerylpenicillamine (SNVP) are novel nitric oxide (NO) donor drugs with anti-platelet and vasodilator properties that are selective for areas of endothelial denudation. Here we assess the inhibitory effect of SNVP on platelet adhesion to angioplastied rabbit carotid arteries.

ID: 3135677