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A rapid and transient peripheral inflammatory response precedes brain inflammation after experimental stroke

Research output: Contribution to journalArticle

  • Katie Z Chapman
  • Verity Q Dale
  • Adám Dénes
  • Gavin Bennett
  • Nancy J Rothwell
  • Stuart M Allan
  • Barry W McColl

Related Edinburgh Organisations

Original languageEnglish
Pages (from-to)1764-1768
Number of pages5
JournalJournal of Cerebral Blood Flow and Metabolism
Volume29
Issue number11
DOIs
Publication statusPublished - Nov 2009

Abstract

Increasing evidence suggests that peripheral inflammatory responses to stroke and other brain injuries have an important role in determining neurological outcome. The mediators of this response and the temporal relationships between peripheral and central inflammatory alterations are poorly understood. In this study, we show that experimental stroke in mice induces a peripheral inflammatory response that peaks 4 h after stroke, and precedes the peak in brain inflammation 24 h after stroke. This peripheral response is dominated by the induction of the chemokine CXCL-1 and the proinflammatory cytokine interleukin-6 and could serve as an accessible target for therapy and as a source of biomarkers predictive of prognosis.

    Research areas

  • chemokine , CXCL-1, interleukin-6, MCAo, peripheral inflammation, stroke

ID: 2165589