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A regulatory domain spanning the repeat sequence RE1 from herpes simplex virus type 1 has cell specific differential functions in trigeminal neurons and fibroblasts

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  • H.C. Stevens
  • C. Fiskerstrand
  • V.J. Bubb
  • R. Dalziel
  • J.P. Quinn

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http://www.sciencedirect.com/science/article/pii/S0014579309007376
Original languageEnglish
Pages (from-to)3335-3338
Number of pages4
JournalFEBS Letters
Volume583
Issue number20
DOIs
StatePublished - Oct 2009

Abstract

In this report we demonstrate that the herpes simplex virus type 1 reiteration element 1 (RE1) (nt: 117158-117353) in concert with its flanking sequences is both a cell specific and stimulus inducible regulatory domain. This region of the virus genome and specifically the RE1 supports differential reporter gene expression in both baby hamster kidney cells and disassociated rat trigeminal ganglia and is present within a region that is implicated in regulating latency of the virus in neuronal cells. Further we demonstrate that this locus is a transcriptional regulatory domain and a target for the transcription factor CCCTC binding protein.

    Research areas

  • CCCTC binding protein , Cell specific enhancer , Herpes simplex virus type 1 , Tandem repeat

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