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Actin-dependent movement of bacterial pathogens

Research output: Contribution to journalLiterature reviewpeer-review

Original languageEnglish
Pages (from-to)91-101
Number of pages11
JournalNature Reviews Microbiology
Volume4
Issue number2
DOIs
Publication statusPublished - Feb 2006

Abstract

Listeria, Rickettsia, Burkholderia, Shigella and Mycobacterium species subvert cellular actin dynamics to facilitate their movement within the host cytosol and to infect neighbouring cells while evading host immune surveillance and promoting their intracellular survival. 'Attaching and effacing' Escherichia coli do not enter host cells but attach intimately to the cell surface, inducing motile actin-rich pedestals, the function of which is currently unclear. The molecular basis of actin-based motility of these bacterial pathogens reveals novel insights about bacterial pathogenesis and fundamental host-cell pathways.

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