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Activation by malaria antigens renders mononuclear cells susceptible to HIV infection and re-activates replication of endogenous HIV in cells from HIV-infected adults

Research output: Contribution to journalArticlepeer-review

  • K Froebel
  • W Howard
  • JR Schafer
  • F Howie
  • J Whitworth
  • P Kaleebu
  • AJ Leigh Brown
  • E Riley

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Original languageEnglish
Pages (from-to)213-217
Number of pages5
JournalParasite Immunology
Volume26
Issue number5
DOIs
Publication statusPublished - May 2004

Abstract

We have tested the hypothesis that activation of T cells by exposure to malaria antigens facilitates both de novo HIV infection and viral reactivation and replication. PBMC from malaria-naive HIV-uninfected European donors could be productively infected with HIV following in vitro stimulation with a lysate of Plasmodium falciparum schizonts and PBMC from malaria-naive and malaria-exposed (semi-immune) HIV-positive adults were induced to produce higher levels of virus after stimulation with the same malaria extract. These findings suggest that effective malaria control measures might con-tribute to reducing the spread of HIV and extending the life span of HIV-infected individuals living in malaria endemic areas.

ID: 1861994