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Ageing and brain white matter structure in 3513 UK Biobank participants

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Original languageEnglish
Article number13629
Pages (from-to)1-13
Number of pages13
JournalNature Communications
Publication statusPublished - 15 Dec 2016


Quantifying the microstructural properties of the human brain’s connections is necessary for understanding normal ageing and disease. We examined brain white matter magnetic resonance imaging (MRI) data in 3,513 generally healthy people aged 44.64-77.12 years from the UK Biobank. Using conventional water diffusion measures and newer, rarely-studied indices from neurite orientation dispersion and density imaging, we document large age associations with white matter microstructure. Mean diffusivity was the most age-sensitive measure, with negative age associations strongest in the thalamic radiation and association fibres. White matter microstructure across brain tracts become increasingly correlated in older age. This may reflect an age-related aggregation of systemic detrimental effects. We report several other novel results, including age associations with hemisphere and sex, and comparative volumetric MRI analyses. Results from this unusually large, single-scanner sample provide one of the most extensive characterisations of age associations with major white matter tracts in the human brain.

    Research areas

  • neurite orientation dispersion, diffusion MRI , alzheimers-disease, life-span, age, integrity, microstructure, noddi, model, tractography

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