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Amide bond formation: beyond the myth of coupling reagents

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Original languageEnglish
Pages (from-to)606-631
Number of pages26
JournalChemical Society Reviews
Volume38
Issue number2
DOIs
Publication statusPublished - 2009

Abstract

Amide bond formation is a fundamentally important reaction in organic synthesis, and is typically mediated by one of a myriad of so-called coupling reagents. This critical review is focussed on the most recently developed coupling reagents with particular attention paid to the pros and cons of the plethora of "acronym'' based reagents. It aims to demystify the process allowing the chemist to make a sensible and educated choice when carrying out an amide coupling reaction (179 references).

    Research areas

  • PHASE PEPTIDE-SYNTHESIS, BENZOTRIAZOL-1-YL DIETHYL PHOSPHATE, N-HYDROXYSUCCINIMIDE ESTERS, SUPPORTED MUKAIYAMA REAGENT, METHYLATED AMINO-ACIDS, MIXED ANHYDRIDE METHOD, CHLORIDE BOP-CL, SOLID-PHASE, HIGHLY EFFICIENT, DIPHENYL PHOSPHATE

ID: 1480719