Edinburgh Research Explorer

Analyses of pig genomes provide insight into porcine demography and evolution

Research output: Contribution to journalArticle

  • Martien A. M. Groenen
  • Hirohide Uenishi
  • Christopher K. Tuggle
  • Yasuhiro Takeuchi
  • Max F. Rothschild
  • Claire Rogel-Gaillard
  • Chankyu Park
  • Denis Milan
  • Hendrik-Jan Megens
  • Shengting Li
  • Denis M. Larkin
  • Heebal Kim
  • Laurent A. F. Frantz
  • Mario Caccamo
  • Hyeonju Ahn
  • Bronwen L. Aken
  • Anna Anselmo
  • Christian Anthon
  • Loretta Auvil
  • Bouabid Badaoui
  • Craig W. Beattie
  • Christian Bendixen
  • Daniel Berman
  • Frank Blecha
  • Jonas Blomberg
  • Lars Bolund
  • Mirte Bosse
  • Sara Botti
  • [No Value] Zhan Bujie
  • Megan Bystrom
  • Boris Capitanu
  • Denise Carvalho-Silva
  • Patrick Chardon
  • Celine Chen
  • Ryan Cheng
  • Sang-Haeng Choi
  • William Chow
  • Richard C. Clark
  • Christopher Clee
  • Richard P. M. A. Crooijmans
  • Harry D. Dawson
  • Patrice Dehais
  • Bert Dibbits
  • Nizar Drou
  • Zhi-Qiang Du
  • Kellye Eversole
  • Joao Fadista
  • Susan Fairley
  • Thomas Faraut
  • Katie E. Fowler
  • Merete Fredholm
  • Eric Fritz
  • James G. R. Gilbert
  • Elisabetta Giuffra
  • Jan Gorodkin
  • Darren K. Griffin
  • Jennifer L. Harrow
  • Alexander Hayward
  • Kerstin Howe
  • Zhi-Liang Hu
  • Sean J. Humphray
  • Toby Hunt
  • Henrik Hornshoj
  • Jin-Tae Jeon
  • Patric Jern
  • Matthew Jones
  • Jerzy Jurka
  • Hiroyuki Kanamori
  • Jaebum Kim
  • Jae-Hwan Kim
  • Kyu-Won Kim
  • Tae-Hun Kim
  • Greger Larson
  • Kyooyeol Lee
  • Kyung-Tai Lee
  • Richard Leggett
  • Harris A. Lewin
  • Yingrui Li
  • Wansheng Liu
  • Jane E. Loveland
  • Yao Lu
  • Joan K. Lunney
  • Jian Ma
  • Ole Madsen
  • Katherine Mann
  • Lucy Matthews
  • Stuart McLaren
  • Takeya Morozumi
  • Michael P. Murtaugh
  • Jitendra Narayan
  • [No Value] Dinh Truong Nguyen
  • Peixiang Ni
  • Song-Jung Oh
  • Suneel Onteru
  • Frank Panitz
  • Eung-Woo Park
  • Hong-Seog Park
  • Geraldine Pascal
  • Yogesh Paudel
  • Miguel Perez-Enciso
  • Ricardo Ramirez-Gonzalez
  • James M. Reecy
  • Sandra Rodriguez-Zas
  • Gary A. Rohrer
  • Lauretta Rund
  • Yongming Sang
  • Kyle Schachtschneider
  • Joshua G. Schraiber
  • John Schwartz
  • Linda Scobie
  • Carol Scott
  • Stephen Searle
  • Bertrand Servin
  • Bruce R. Southey
  • Goran Sperber
  • Peter Stadler
  • Jonathan V. Sweedler
  • Hakim Tafer
  • Bo Thomsen
  • Rashmi Wali
  • Jian Wang
  • Jun Wang
  • Simon White
  • Xun Xu
  • Martine Yerle
  • Guojie Zhang
  • Jianguo Zhang
  • Jie Zhang
  • Shuhong Zhao
  • Jane Rogers
  • Carol Churcher
  • Lawrence B. Schook

Related Edinburgh Organisations

Open Access permissions

Open

Documents

  • Download as Adobe PDF

    Rights statement: Available under Open Access. © 2012 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. partner of AGORA, HINARI, OARE, INASP, ORCID, CrossRef and COUNTER

    Final published version, 496 KB, PDF-document

http://www.nature.com/nature/journal/v491/n7424/full/nature11622.html
Original languageEnglish
Pages (from-to)393-398
Number of pages6
JournalNature
Volume491
Issue number7424
DOIs
StatePublished - 15 Nov 2012

Abstract

For 10,000 years pigs and humans have shared a close and complex relationship. From domestication to modern breeding practices, humans have shaped the genomes of domestic pigs. Here we present the assembly and analysis of the genome sequence of a female domestic Duroc pig (Sus scrofa) and a comparison with the genomes of wild and domestic pigs from Europe and Asia. Wild pigs emerged in South East Asia and subsequently spread across Eurasia. Our results reveal a deep phylogenetic split between European and Asian wild boars similar to 1 million years ago, and a selective sweep analysis indicates selection on genes involved in RNA processing and regulation. Genes associated with immune response and olfaction exhibit fast evolution. Pigs have the largest repertoire of functional olfactory receptor genes, reflecting the importance of smell in this scavenging animal. The pig genome sequence provides an important resource for further improvements of this important livestock species, and our identification of many putative disease-causing variants extends the potential of the pig as a biomedical model.

    Research areas

  • Genomics , Genetics, Evolution

Download statistics

No data available

ID: 5382887