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Animal Models to Explore the Effects of Glucocorticoids on Skeletal Growth and Structure: Animal Models for GC Effects on Skeleton

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Original languageEnglish
Article numberJOE-17-0361
Pages (from-to)R69-R91
JournalJournal of Endocrinology
Volume236
Issue number1
Early online date19 Oct 2017
DOIs
Publication statusPublished - 1 Jan 2018

Abstract

Glucocorticoids (GCs) are effective for the treatment of many chronic conditions but their use is associated with frequent and wide-ranging adverse effects including osteoporosis and growth retardation. The mechanisms that underlie the undesirable effects of GCs on skeletal development are unclear and there is no proven effective treatment to combat them. An in-vivo model that investigates the development and progression of GC-induced changes in bone is, therefore, important and a well characterized pre-clinical model is vital for the evaluation of new interventions. Currently, there is no established animal model to investigate GC effects on skeletal development and there are pros and cons to consider with the different protocols used to induce osteoporosis and growth retardation. This review will summarize the literature and highlight the models and techniques employed in experimental studies to date.

    Research areas

  • glucocorticoids, , , growth, skeletal development, osteoporosis, mouse

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