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Antibiotic prophylaxis in veterinary cancer chemotherapy: a review and recommendations.

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Original languageEnglish
Pages (from-to)301-310
JournalVeterinary and Comparative Oncology
Issue number3
Early online date12 Jun 2018
Publication statusPublished - Sep 2018


Bacterial infection following cancer chemotherapy-induced neutropenia is a serious cause of morbidity and mortality in human and veterinary patients. Antimicrobial prophylaxis is contro-versial in the human oncology field, as any decreased incidence in bacterial infections is countered by patient adverse effects and increased antimicrobial resistance. Comprehensive
guidelines exist to aid human oncologists in prescribing antimicrobial prophylaxis but similar recommendations are not available in veterinary literature. As the veterinarian's role in antimi-crobial stewardship is increasingly emphasized, it is vital that veterinary oncologists implement appropriate antimicrobial use. By considering the available human and veterinary literature we
present an overview of current clinical practices and are able to suggest recommendations for prophylactic antimicrobial use in veterinary cancer chemotherapy patients.

    Research areas

  • antimicrobial prophylaxis, antimicrobial stewardship, antineoplastic agents, neutropenia, veterinary oncology, veterinary practice guidelines as topic

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