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Antibody responses to P. falciparum blood stage antigens and incidence of clinical malaria in children living in endemic area in Burkina Faso

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  • Mariama K Cherif
  • Oumarou Ouédraogo
  • Guillaume S Sanou
  • Amidou Diarra
  • Alphonse Ouédraogo
  • Alfred Tiono
  • David R Cavanagh
  • Theisen Michael
  • Amadou T Konaté
  • Nora L Watson
  • Megan Sanza
  • Tina J T Dube
  • Sodiomon B Sirima
  • Issa Nebié

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    Rights statement: © The Author(s) 2017. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/ publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Original languageEnglish
Pages (from-to)472
Number of pages10
JournalBMC Research Notes
Issue number1
Publication statusPublished - 8 Sep 2017


BACKGROUND: High parasite-specific antibody levels are generally associated with low susceptibility to Plasmodium falciparum malaria. This has been supported by several studies in which clinical malaria cases of P. falciparum malaria were reported to be associated with low antibody avidities. This study was conducted to evaluate the role of age, malaria transmission intensity and incidence of clinical malaria in the induction of protective humoral immune response against P. falciparum malaria in children living in Burkina Faso.

METHODS: We combined levels of IgG and IgG subclasses responses to P. falciparum antigens: Merozoite Surface Protein 3 (MSP3), Merozoite Surface Protein 2a (MSP2a), Merozoite Surface Protein 2b (MSP2b), Glutamate Rich Protein R0 (GLURP R0) and Glutamate Rich Protein R2 (GLURP R2) in plasma samples from 325 children under five (05) years with age, malaria transmission season and malaria incidence.

RESULTS: We notice higher prevalence of P. falciparum infection in low transmission season compared to high malaria transmission season. While, parasite density was lower in low transmission than high transmission season. IgG against all antigens investigated increased with age. High levels of IgG and IgG subclasses to all tested antigens except for GLURP R2 were associated with the intensity of malaria transmission. IgG to MSP3, MSP2b, GLURP R2 and GLURP R0 were associated with low incidence of malaria. All IgG subclasses were associated with low incidence of P. falciparum malaria, but these associations were stronger for cytophilic IgGs.

CONCLUSIONS: On the basis of the data presented in this study, we conclude that the induction of humoral immune response to tested malaria antigens is related to age, transmission season level and incidence of clinical malaria.

    Research areas

  • Adolescent, Age Factors, Antibodies, Protozoan/blood, Antibody Formation/immunology, Antigens, Protozoan/immunology, Burkina Faso/epidemiology, Child, Child, Preschool, Female, Humans, Incidence, Infant, Malaria, Falciparum/blood, Male, Plasmodium falciparum/immunology

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