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APC/C(Cdh1) Enables Removal of Shugoshin-2 from the Arms of Bivalent Chromosomes by Moderating Cyclin-Dependent Kinase Activity

Research output: Contribution to journalArticle

  • Ahmed Rattani
  • Randy Ballesteros Mejia
  • Katherine Roberts
  • Maurici B Roig
  • Jonathan Godwin
  • Michael Hopkins
  • Manuel Eguren
  • Luis Sanchez-Pulido
  • Elwy Okaz
  • Sugako Ogushi
  • Magda Wolna
  • Jean Metson
  • Alberto M Pendás
  • Marcos Malumbres
  • Béla Novák
  • Mary Herbert
  • Kim Nasmyth

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Original languageEnglish
Pages (from-to)1462-1476.e5
JournalCurrent biology : CB
Issue number10
Early online date11 May 2017
Publication statusPublished - 22 May 2017


In mammalian females, germ cells remain arrested as primordial follicles. Resumption of meiosis is heralded by germinal vesicle breakdown, condensation of chromosomes, and their eventual alignment on metaphase plates. At the first meiotic division, anaphase-promoting complex/cyclosome associated with Cdc20 (APC/C(Cdc20)) activates separase and thereby destroys cohesion along chromosome arms. Because cohesion around centromeres is protected by shugoshin-2, sister chromatids remain attached through centromeric/pericentromeric cohesin. We show here that, by promoting proteolysis of cyclins and Cdc25B at the germinal vesicle (GV) stage, APC/C associated with the Cdh1 protein (APC/C(Cdh1)) delays the increase in Cdk1 activity, leading to germinal vesicle breakdown (GVBD). More surprisingly, by moderating the rate at which Cdk1 is activated following GVBD, APC/C(Cdh1) creates conditions necessary for the removal of shugoshin-2 from chromosome arms by the Aurora B/C kinase, an event crucial for the efficient resolution of chiasmata.

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