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Applying modern Omic technologies to the Neuronal Ceroid Lipofuscinoses

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Original languageEnglish
JournalBiochimica et biophysica acta-Molecular basis of disease
Early online date15 Jun 2019
Publication statusE-pub ahead of print - 15 Jun 2019


The neuronal ceroid lipofuscinoses are a group of severe and progressive neurodegenerative disorders, which generally present during childhood. With new treatments emerging on the horizon, there is a growing need to understand the specific disease mechanisms as well as identify prospective biomarkers for use to stratify patients and monitor treatment. The use of Omics technologies to NCLs have the potential to address this need. We discuss the recent use and outcomes of Omics to various forms of NCL including identification of interactomes, affected biological pathways and potential biomarker candidates. We also identify common
pathways affected in NCL across the reviewed studies.

    Research areas

  • Neuronal ceroid lipofuscinoses, Batten disease, CLN1-14, proteomics, metabolomics

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