Edinburgh Research Explorer

Approaches to high throughput physical organic chemistry

Research output: Contribution to journalArticle

Related Edinburgh Organisations

Original languageEnglish
Pages (from-to)587-592
Number of pages6
JournalOrganic & Biomolecular chemistry
Volume5
Issue number4
DOIs
Publication statusPublished - 2007

Abstract

High throughput (HT) techniques are now extensively used for the synthesis of libraries of several thousands of compounds. More recently, HT methods began to be applied to other areas, such as physical organic chemistry. This has allowed for instance the development of tools for HT reaction assessment, HT kinetic and thermodynamic measurements, and physicochemical property pro. ling, using a broad set of analytical tools, ranging from mass spectrometry to image analysis based techniques. This article provides an overview of recent HT physical organic chemistry techniques. Special attention is given to the application of quantitative analytical constructs for HT monomer reactivity pro. ling and HT evaluation of Hammett parameters.

    Research areas

  • SOLID-PHASE CHEMISTRY, ANALYTICAL CONSTRUCTS, CHEMICAL-STABILITY, LINKER, REACTIVITY, CATALYSTS

ID: 1513250