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Association Between Schizophrenia-Related Polygenic Liability and the Occurrence and Level of Mood-Incongruent Psychotic Symptoms in Bipolar Disorder

Research output: Contribution to journalArticle

  • Judith Allardyce
  • Ganna Leonenko
  • Marian Hamshere
  • Antonio F. Pardiñas
  • Liz Forty
  • Sarah Knott
  • Katherine Gordon-Smith
  • David Porteous
  • Caroline Haywood
  • Arianna Di Florio
  • Lisa A Jones
  • Andrew McIntosh
  • Michael J Owen
  • Peter A Holmans
  • James T.R. Walters
  • Nicholas Craddock
  • Ian R Jones
  • Michael C O'Donovan
  • Valentina Escott-Price

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    Rights statement: This is an open access article distributed under the terms of the CC-BY License. © 2017 Allardyce J et al. JAMA Psychiatry.

    Final published version, 428 KB, PDF document

Original languageEnglish
Number of pages9
JournalJAMA Psychiatry
Early online date22 Nov 2017
Publication statusE-pub ahead of print - 22 Nov 2017


Question: what is the relationship between schizophrenia related polygenic liability and the occurrence and level of mood-incongruence of psychotic symptoms in bipolar disorder (BD)? Findings: in this case-control study including 4436 BD cases, 4976 schizophrenia cases and 9012 controls, there was an exposure-response gradient of polygenic risk: Schizophrenia > BD with prominent mood-incongruent psychotic features > BD with mood-congruent psychotic features > BD with no psychosis, all differential associations were statistically-significant. Meaning: A gradient of genetic liability across schizophrenia and bipolar disorder, indexed by the occurrence of psychosis and level of mood-incongruence has been shown for the first time.

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