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Association of IGF1 and KDM5A polymorphisms with performance, fatness and carcass traits in chickens

Research output: Contribution to journalArticle

  • Clarissa Boschiero
  • Erika C Jorge
  • Kerli Ninov
  • Kátia Nones
  • Millor Fernandes do Rosário
  • Luiz Lehmann Coutinho
  • Mônica Corrêa Ledur
  • David W Burt
  • Ana Silvia A M T Moura

Related Edinburgh Organisations

Original languageEnglish
Pages (from-to)103-112
Number of pages10
JournalJournal of applied genetics
Issue number1
Early online date30 Dec 2012
Publication statusPublished - Feb 2013


Two functional and positional candidate genes were selected in a region of chicken chromosome 1 (GGA1), based on their biological roles, and also where several quantitative trait loci (QTL) have been mapped and associated with performance, fatness and carcass traits in chickens. The insulin-like growth factor 1 (IGF1) gene has been associated with several physiological functions related to growth. The lysine (K)-specific demethylase 5A (KDM5A) gene participates in the epigenetic regulation of genes involved with the cell cycle. Our objective was to find associations of selected single-nucleotide polymorphisms (SNPs) in these genes with performance, fatness and carcass traits in 165 F(2) chickens from a resource population. In the IGF1 gene, 17 SNPs were detected, and in the KDM5A gene, nine SNPs were detected. IGF1 SNP c.47673G > A was associated with body weight and haematocrit percentage, and also with feed intake and percentages of abdominal fat and gizzard genotype × sex interactions. KDM5A SNP c.34208C > T genotype × sex interaction affected body weight, feed intake, percentages of abdominal fat (p = 0.0001), carcass, gizzard and haematocrit. A strong association of the diplotype × sex interaction (p 

    Research areas

  • Adipose Tissue/metabolism, Animals, Base Sequence, Biometry, Body Weight/genetics, Chickens/anatomy & histology, Chickens/genetics, Female, Genotype, Hematocrit, Insulin-Like Growth Factor I/genetics, Male, Polymorphism, Single Nucleotide, Quantitative Trait Loci, Retinoblastoma-Binding Protein 2/genetics, Sequence Analysis, DNA

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