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Associations between a polymorphism in the pleiotropic GCKR and Age-related phenotypes: the HALCyon programme

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Original languageEnglish
Pages (from-to)e70045
JournalPLoS ONE
Volume8
Issue number7
DOIs
Publication statusPublished - 23 Jul 2013

Abstract

The glucokinase regulatory protein encoded by GCKR plays an important role in glucose metabolism and a single nucleotide polymorphism (SNP) rs1260326 (P446L) in the gene has been associated with several age-related biomarkers, including triglycerides, glucose, insulin and apolipoproteins. However, associations between SNPs in the gene and other ageing phenotypes such as cognitive and physical capability have not been reported.

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