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Central nervous system regeneration is driven by microglia necroptosis and repopulation

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Original languageEnglish
Pages (from-to)1046–1052
Number of pages7
JournalNature Neuroscience
Volume22
Issue number7
DOIs
Publication statusPublished - 10 Jun 2019

Abstract

Failed regeneration of CNS myelin contributes to clinical decline in neuroinflammatory and neurodegenerative diseases, for which there is an unmet therapeutic need. Here we reveal that efficient remyelination requires death of proinflammatory microglia followed by repopulation to a pro-regenerative state. We propose that impaired microglia death and/or repopulation may underpin dysregulated microglia activation in neurological diseases, and we reveal therapeutic targets to promote white matter regeneration.

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