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CFTR Protects against Mycobacterium abscessus Infection by Fine-Tuning Host Oxidative Defenses

Research output: Contribution to journalArticle

  • Audrey Bernut
  • Christian Dupont
  • Nikolay V. Ogryzko
  • Aymeric Neyret
  • Jean Louis Herrmann
  • R. Andres Floto
  • Stephen A. Renshaw
  • Laurent Kremer

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Original languageEnglish
JournalCell Reports
DOIs
Publication statusPublished - 12 Feb 2019

Abstract

Bernut et al. investigate the mechanism by which cystic fibrosis patients are vulnerable to Mycobacterium abscessus infection. Using zebrafish, they show that dysfunction of CFTR reduces both macrophage bactericidal activity and neutrophil recruitment to the forming protective granulomas. Together, this leads to hypersusceptibility to M. abscessus infection and larval death.

    Research areas

  • CFTR, cystic fibrosis, innate immunity, Mycobacterium abscessus, NADPH oxidase, pathogenesis, zebrafish

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