Edinburgh Research Explorer

CFTR Protects against Mycobacterium abscessus Infection by Fine-Tuning Host Oxidative Defenses

Research output: Contribution to journalArticle

  • Audrey Bernut
  • Christian Dupont
  • Nikolay V. Ogryzko
  • Aymeric Neyret
  • Jean Louis Herrmann
  • R. Andres Floto
  • Stephen A. Renshaw
  • Laurent Kremer

Related Edinburgh Organisations

Open Access permissions



Original languageEnglish
JournalCell Reports
Publication statusPublished - 12 Feb 2019


Bernut et al. investigate the mechanism by which cystic fibrosis patients are vulnerable to Mycobacterium abscessus infection. Using zebrafish, they show that dysfunction of CFTR reduces both macrophage bactericidal activity and neutrophil recruitment to the forming protective granulomas. Together, this leads to hypersusceptibility to M. abscessus infection and larval death.

    Research areas

  • CFTR, cystic fibrosis, innate immunity, Mycobacterium abscessus, NADPH oxidase, pathogenesis, zebrafish

Download statistics

No data available

ID: 80058866