Edinburgh Research Explorer

Chapter 39 Liver stem cells

Research output: Chapter in Book/Report/Conference proceedingChapter

Original languageEnglish
Title of host publication Principles of Tissue Engineering
EditorsRobert Lanza, Robert Langer, Joseph Vacanti, Anthony Atala
PublisherELSEVIER ACADEMIC PRESS INC
Edition5
ISBN (Print)9780128184226
Publication statusPublished - 30 Mar 2020

Abstract

Liver disease is a global health issue. Although the liver is capable of regeneration, in the presence of severe organ injury this process is impaired. Although liver transplantation can be used to effectively treat hepatic failure, it is an invasive surgical procedure that is limited by organ donation. Therefore the development of renewable sources of human liver tissue for organ repair and disease modelling is very attractive. In this chapter, we describe recent advances in the generation and characterisation of liver stem cells and provide an overview of new technologies to generate human liver tissue for translational medicine.

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