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Characterisation of Matrix Vesicles in Skeletal and Soft Tissue Mineralisation

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    Rights statement: © 2016 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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http://www.sciencedirect.com/science/article/pii/S875632821630093X
Original languageEnglish
Pages (from-to)147-158
JournalBone
Volume87
Early online date9 Apr 2016
DOIs
Publication statusE-pub ahead of print - 9 Apr 2016

Abstract

The importance of matrix vesicles (MVs) have been repeatedly highlighted in the formation of cartilage, bone, and dentin since their discovery in 1967. These nano-vesicular structures, which are found in the extracellular matrix, are believed to be one of the sites of mineral nucleation that occurs in the organic matrix of the skeletal tissues. In the more recent years, there have been numerous reports on the observation of MV-like particles in calcified vascular tissues that could be playing a similar role. Therefore, here, we review the characteristics MVs possess that enable them to participate in mineral deposition. Additionally, we outline the content of skeletal tissue- and soft tissue-derived MVs, and discuss their key mineralisation mediators that could be targeted for future therapeutic use.

    Research areas

  • matrix vesicles, vascular calcification, mineralisation, phosphate, mechanisms

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