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Characterization of the proteome, diseases and evolution of the human postsynaptic density

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    Rights statement: Published in final edited form as: Nat Neurosci. 2011 January ; 14(1): 19–21. doi:10.1038/nn.2719.

    Accepted author manuscript, 621 KB, PDF document

Original languageEnglish
Pages (from-to)19-21
Number of pages3
JournalNature Neuroscience
Issue number1
Early online date19 Dec 2010
Publication statusPublished - Jan 2011


We isolated the postsynaptic density from human neocortex (hPSD) and identified 1,461 proteins. hPSD mutations cause 133 neurological and psychiatric diseases and were enriched in cognitive, affective and motor phenotypes underpinned by sets of genes. Strong protein sequence conservation in mammalian lineages, particularly in hub proteins, indicates conserved function and organization in primate and rodent models. The hPSD is an important structure for nervous system disease and behavior.

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