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Chloromethyl-triazole: a new motif for site-selective pseudo-acylation of proteins

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http://xlink.rsc.org/?DOI=C6CC06801D
Original languageEnglish
Pages (from-to)12230-12232
Number of pages3
JournalChemical Communications
Volume52
Issue number82
Early online date13 Sep 2016
DOIs
Publication statusE-pub ahead of print - 13 Sep 2016

Abstract

Rapid, site-selective modification of cysteine residues with chloromethyl-triazole derivatives generates pseudo-acyl sLys motifs, mimicking important post-translational modifications. Near-native biotinylation of peptide and protein substrates is shown to be site-selective and modified histone H4 retains functional activity.

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