Edinburgh Research Explorer

Chromatin at the nuclear periphery and the regulation of genome functions

Research output: Contribution to journalReview article

Related Edinburgh Organisations

Documents

Original languageEnglish
Pages (from-to)111-22
Number of pages12
JournalHistochemistry and cell biology
Volume144
Issue number2
Early online date14 Jul 2015
DOIs
Publication statusPublished - Aug 2015

Abstract

Chromatin is not randomly organized in the nucleus, and its spatial organization participates in the regulation of genome functions. However, this spatial organization is also not entirely fixed and modifications of chromatin architecture are implicated in physiological processes such as differentiation or senescence. One of the most striking features of chromatin architecture is the concentration of heterochromatin at the nuclear periphery. A closer examination of the association of chromatin at the nuclear periphery reveals that heterochromatin accumulates at the nuclear lamina, whereas nuclear pores are usually devoid of heterochromatin. After summarizing the current techniques used to study the attachment of chromatin at the nuclear lamina or the nuclear pores, we review the mechanisms underlying these attachments, their plasticity and their consequences on the regulation of gene expression, DNA repair and replication.

Download statistics

No data available

ID: 21129722