Edinburgh Research Explorer

Chromosomal position effects and the modulation of transgene expression

Research output: Contribution to journalArticle

  • A J Clark
  • P Bissinger
  • D W Bullock
  • S Damak
  • R Wallace
  • C B Whitelaw
  • F Yull

Related Edinburgh Organisations

Original languageEnglish
Pages (from-to)589-98
Number of pages10
JournalReproduction, Fertility and Development
Issue number5
Publication statusPublished - 1994


Chromosomal position effects can influence strongly the transcription of foreign genes in transgenic animals. This results in low frequencies and levels of gene expression and, in some cases, in aberrant patterns of expression. Strategies for overcoming these effects are described with particular reference to their application in embryonic stem cells.

    Research areas

  • Animals, Chromosomes, DNA, Recombinant, Embryo, Mammalian, Gene Expression, Gene Targeting, Gene Transfer Techniques, Humans, Stem Cells

ID: 8776905