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Combinations of antibiotics and nonantibiotic drugs enhance antimicrobial efficacy

Research output: Contribution to journalArticle

  • Linda Ejim
  • Maya A Farha
  • Shannon B Falconer
  • Jan Wildenhain
  • Brian K Coombes
  • Mike Tyers
  • Eric D Brown
  • Gerard D Wright

Related Edinburgh Organisations

Original languageEnglish
Pages (from-to)348-350
Number of pages3
JournalNature Chemical Biology
Volume7
Issue number6
DOIs
Publication statusPublished - Jun 2011

Abstract

Combinations of antibiotics are commonly used in medicine to broaden antimicrobial spectrum and generate synergistic effects. Alternatively, combination of nonantibiotic drugs with antibiotics offers an opportunity to sample a previously untapped expanse of bioactive chemical space. We screened a collection of drugs to identify compounds that augment the activity of the antibiotic minocycline. Unexpected synergistic drug combinations exhibited in vitro and in vivo activity against bacterial pathogens, including multidrug-resistant isolates.

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