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Combinations of antibiotics and nonantibiotic drugs enhance antimicrobial efficacy

Research output: Contribution to journalArticle

  • Linda Ejim
  • Maya A Farha
  • Shannon B Falconer
  • Jan Wildenhain
  • Brian K Coombes
  • Mike Tyers
  • Eric D Brown
  • Gerard D Wright

Related Edinburgh Organisations

Original languageEnglish
Pages (from-to)348-350
Number of pages3
JournalNature Chemical Biology
Issue number6
Publication statusPublished - Jun 2011


Combinations of antibiotics are commonly used in medicine to broaden antimicrobial spectrum and generate synergistic effects. Alternatively, combination of nonantibiotic drugs with antibiotics offers an opportunity to sample a previously untapped expanse of bioactive chemical space. We screened a collection of drugs to identify compounds that augment the activity of the antibiotic minocycline. Unexpected synergistic drug combinations exhibited in vitro and in vivo activity against bacterial pathogens, including multidrug-resistant isolates.

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